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CDNF cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol CDNF
Entrez Gene ID 441549
Full Name cerebral dopamine neurotrophic factor
Synonyms ARMETL1
General protein information
Preferred Names

cerebral dopamine neurotrophic factor

Names

cerebral dopamine neurotrophic factor
ARMET-like protein 1
arginine-rich, mutated in early stage tumors-like 1
conserved dopamine neurotrophic factor
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

10

10p13
Disorder MIM:

611233


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001029954.2 NP_001025125.2 cerebral dopamine neurotrophic factor precursor
NM_001029954.3 NP_001025125.2 cerebral dopamine neurotrophic factor precursor
XM_011519488.2 XP_011517790.1 cerebral dopamine neurotrophic factor isoform X1

Pathways from BioSystems


Homologies


Homo sapiens (human) CDNF NP_001025125.2
Canis lupus familiaris (dog) CDNF XP_848954.2
Mus musculus (house mouse) Cdnf NP_808315.1
CDNF XP_001088321.1
Pan troglodytes (chimpanzee) CDNF XP_507666.2
Bos taurus (cattle) CDNF NP_001192698.1
Danio rerio (zebrafish) cdnf NP_001116753.1
Rattus norvegicus (Norway rat) Cdnf NP_001032632.1
Xenopus tropicalis (tropical clawed frog) cdnf XP_002935290.1

Gene Ontology


Bibliography

Related articles in PubMed

Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population.
Yang Y, Yu H, Li W, Liu B, Zhang H, Ding S, Lu Y, Jiang T, Lv L
Behavioral and brain functions : BBF14(1)1(2018 Jan)

Cerebral Dopamine Neurotrophic Factor: A Potential Therapeutic Agent for Parkinson's Disease.
Tang T, Li Y, Jiao Q, Du X, Jiang H
Neuroscience bulletin33(5)568-575(2017 Oct)

Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression.
Wang L, Wang Z, Zhu R, Bi J, Feng X, Liu W, Wu J, Zhang H, Wu H, Kong W, Yu B, Yu X
PloS one12(6)e0179476(2017)

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.
Kemppainen S, Lindholm P, Galli E, Lahtinen HM, Koivisto H, H?m?l?inen E, Saarma M, Tanila H
Behavioural brain research2911-11(2015 Sep)

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against ?-Synuclein Oligomers.
Latge C, Cabral KM, de Oliveira GA, Raymundo DP, Freitas JA, Johanson L, Rom?o LF, Palhano FL, Herrmann T, Almeida MS, Foguel D
The Journal of biological chemistry290(33)20527-40(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion).
Title: Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression.

Results suggest that CDNF treatment selectively enhances long-term memory consolidation
Title: Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.

showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers
Title: The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against ?-Synuclein Oligomers.

Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease.
Title: Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra.

Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found.
Title: Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease.

The following CDNF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDNF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu04393 NM_001029954.3
Latest version!		 Homo sapiens cerebral dopamine neurotrophic factor (CDNF), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$49.50-$69.30
$99.00
OHu80351 XM_011519488.2
Latest version!		 Homo sapiens cerebral dopamine neurotrophic factor (CDNF), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu04393 NM_001029954.2 Homo sapiens cerebral dopamine neurotrophic factor (CDNF), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu04393
Clone ID Related Accession (Same CDS sequence) NM_001029954.2 , NM_001029954.3
Accession Version NM_001029954.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 564bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-09-17
Organism Homo sapiens(human)
Product cerebral dopamine neurotrophic factor precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AV657190.1, CN311321.1, BG213461.1, BQ025443.1 and AK131035.1. On or before Dec 2, 2005 this sequence version replaced XM_497214.1, NM_001029954.1. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.244857.1, SRR1660805.139062.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGTGGTGCG CGAGCCCAGT TGCTGTGGTG GCCTTTTGCG CCGGGCTTTT GGTCTCTCAC 
CCGGTGCTGA CGCAGGGCCA GGAGGCCGGG GGGCGGCCAG GGGCCGACTG TGAAGTATGT 
AAAGAATTCT TGAACCGATT CTACAAGTCA CTGATAGACA GAGGAGTTAA CTTTTCGCTG 
GACACTATAG AGAAAGAATT GATCAGTTTT TGCTTGGACA CCAAAGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC CACAAAAGAC GCAGCCACAA AGATCCTAAG TGAAGTCACT 
CGCCCAATGA GTGTGCATAT GCCTGCAATG AAGATTTGTG AGAAGCTGAA GAAGTTGGAT 
AGCCAGATCT GTGAGCTGAA ATATGAAAAA ACACTGGACT TGGCATCAGT TGACCTGCGG 
AAGATGAGAG TGGCAGAGCT GAAGCAGATC CTGCATAGCT GGGGGGAGGA GTGCAGGGCC 
TGTGCAGAAA AAACTGACTA TGTGAATCTC ATTCAAGAGC TGGCCCCCAA GTATGCAGCG 
ACACACCCCA AAACAGAGCT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001025125.2
CDS39..602
Translation

Target ORF information:

RefSeq Version NM_001029954.2
Organism Homo sapiens(human)
Definition Homo sapiens cerebral dopamine neurotrophic factor (CDNF), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001029954.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTGGTGCG CGAGCCCAGT TGCTGTGGTG GCCTTTTGCG CCGGGCTTTT GGTCTCTCAC 
CCGGTGCTGA CGCAGGGCCA GGAGGCCGGG GGGCGGCCAG GGGCCGACTG TGAAGTATGT 
AAAGAATTCT TGAACCGATT CTACAAGTCA CTGATAGACA GAGGAGTTAA CTTTTCGCTG 
GACACTATAG AGAAAGAATT GATCAGTTTT TGCTTGGACA CCAAAGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC CACAAAAGAC GCAGCCACAA AGATCCTAAG TGAAGTCACT 
CGCCCAATGA GTGTGCATAT GCCTGCAATG AAGATTTGTG AGAAGCTGAA GAAGTTGGAT 
AGCCAGATCT GTGAGCTGAA ATATGAAAAA ACACTGGACT TGGCATCAGT TGACCTGCGG 
AAGATGAGAG TGGCAGAGCT GAAGCAGATC CTGCATAGCT GGGGGGAGGA GTGCAGGGCC 
TGTGCAGAAA AAACTGACTA TGTGAATCTC ATTCAAGAGC TGGCCCCCAA GTATGCAGCG 
ACACACCCCA AAACAGAGCT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu04393
Clone ID Related Accession (Same CDS sequence) NM_001029954.2 , NM_001029954.3
Accession Version NM_001029954.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 564bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-04-30
Organism Homo sapiens(human)
Product cerebral dopamine neurotrophic factor precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069544.9, AV657190.1, CN311321.1, BG213461.1, BQ025443.1 and AK131035.1. On Nov 23, 2018 this sequence version replaced NM_001029954.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DC391788.1, SRR1660803.244857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000465530.2/ ENSP00000419395.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
ATGTGGTGCG CGAGCCCAGT TGCTGTGGTG GCCTTTTGCG CCGGGCTTTT GGTCTCTCAC 
CCGGTGCTGA CGCAGGGCCA GGAGGCCGGG GGGCGGCCAG GGGCCGACTG TGAAGTATGT 
AAAGAATTCT TGAACCGATT CTACAAGTCA CTGATAGACA GAGGAGTTAA CTTTTCGCTG 
GACACTATAG AGAAAGAATT GATCAGTTTT TGCTTGGACA CCAAAGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC CACAAAAGAC GCAGCCACAA AGATCCTAAG TGAAGTCACT 
CGCCCAATGA GTGTGCATAT GCCTGCAATG AAGATTTGTG AGAAGCTGAA GAAGTTGGAT 
AGCCAGATCT GTGAGCTGAA ATATGAAAAA ACACTGGACT TGGCATCAGT TGACCTGCGG 
AAGATGAGAG TGGCAGAGCT GAAGCAGATC CTGCATAGCT GGGGGGAGGA GTGCAGGGCC 
TGTGCAGAAA AAACTGACTA TGTGAATCTC ATTCAAGAGC TGGCCCCCAA GTATGCAGCG 
ACACACCCCA AAACAGAGCT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001025125.2
CDS92..655
Translation

Target ORF information:

RefSeq Version NM_001029954.3
Organism Homo sapiens(human)
Definition Homo sapiens cerebral dopamine neurotrophic factor (CDNF), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001029954.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTGGTGCG CGAGCCCAGT TGCTGTGGTG GCCTTTTGCG CCGGGCTTTT GGTCTCTCAC 
CCGGTGCTGA CGCAGGGCCA GGAGGCCGGG GGGCGGCCAG GGGCCGACTG TGAAGTATGT 
AAAGAATTCT TGAACCGATT CTACAAGTCA CTGATAGACA GAGGAGTTAA CTTTTCGCTG 
GACACTATAG AGAAAGAATT GATCAGTTTT TGCTTGGACA CCAAAGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC CACAAAAGAC GCAGCCACAA AGATCCTAAG TGAAGTCACT 
CGCCCAATGA GTGTGCATAT GCCTGCAATG AAGATTTGTG AGAAGCTGAA GAAGTTGGAT 
AGCCAGATCT GTGAGCTGAA ATATGAAAAA ACACTGGACT TGGCATCAGT TGACCTGCGG 
AAGATGAGAG TGGCAGAGCT GAAGCAGATC CTGCATAGCT GGGGGGAGGA GTGCAGGGCC 
TGTGCAGAAA AAACTGACTA TGTGAATCTC ATTCAAGAGC TGGCCCCCAA GTATGCAGCG 
ACACACCCCA AAACAGAGCT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu80351
Clone ID Related Accession (Same CDS sequence) XM_011519488.2
Accession Version XM_011519488.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 591bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product cerebral dopamine neurotrophic factor isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011519488.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGTGGTGCG CGAGCCCAGT TGCTGTGGTG GCCTTTTGCG CCGGGCTTTT GGTCTCTCAC 
CCGGTGCTGA CGCAGGGCCA GGAGGCCGGG GGGCGGCCAG GGGCCGACTG TGAAGTATGT 
AAAGAATTCT TGAACCGATT CTACAAGTCA CTGATAGACA GAGGAGTTAA CTTTTCGCTG 
GACACTATAG AGAAAGAATT GATCAGTTTT TGCTTGGACA CCAAAGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC CACAAAAGAC GCAGCCACAA AGATCCTAAG TGAAGTCACT 
CGCCCAATGA GTGTGCATAT GCCTGCAATG AAGATTTGTG AGAAGCTGAA GAAGTTGGAT 
AGCCAGATCT GTGAGCTGAA ATATGGTATA ACACAGCCCC GTGTTTTTCC CAAAAAAACA 
CTGGACTTGG CATCAGTTGA CCTGCGGAAG ATGAGAGTGG CAGAGCTGAA GCAGATCCTG 
CATAGCTGGG GGGAGGAGTG CAGGGCCTGT GCAGAAAAAA CTGACTATGT GAATCTCATT 
CAAGAGCTGG CCCCCAAGTA TGCAGCGACA CACCCCAAAA CAGAGCTCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011517790.1
CDS128..718
Translation

Target ORF information:

RefSeq Version XM_011519488.2
Organism Homo sapiens(human)
Definition Homo sapiens cerebral dopamine neurotrophic factor (CDNF), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011519488.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTGGTGCG CGAGCCCAGT TGCTGTGGTG GCCTTTTGCG CCGGGCTTTT GGTCTCTCAC 
CCGGTGCTGA CGCAGGGCCA GGAGGCCGGG GGGCGGCCAG GGGCCGACTG TGAAGTATGT 
AAAGAATTCT TGAACCGATT CTACAAGTCA CTGATAGACA GAGGAGTTAA CTTTTCGCTG 
GACACTATAG AGAAAGAATT GATCAGTTTT TGCTTGGACA CCAAAGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC CACAAAAGAC GCAGCCACAA AGATCCTAAG TGAAGTCACT 
CGCCCAATGA GTGTGCATAT GCCTGCAATG AAGATTTGTG AGAAGCTGAA GAAGTTGGAT 
AGCCAGATCT GTGAGCTGAA ATATGGTATA ACACAGCCCC GTGTTTTTCC CAAAAAAACA 
CTGGACTTGG CATCAGTTGA CCTGCGGAAG ATGAGAGTGG CAGAGCTGAA GCAGATCCTG 
CATAGCTGGG GGGAGGAGTG CAGGGCCTGT GCAGAAAAAA CTGACTATGT GAATCTCATT 
CAAGAGCTGG CCCCCAAGTA TGCAGCGACA CACCCCAAAA CAGAGCTCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population.
Behavioral and brain functions : BBF14(1)1(2018 Jan)
Yang Y,Yu H,Li W,Liu B,Zhang H,Ding S,Lu Y,Jiang T,Lv L


book

Cerebral Dopamine Neurotrophic Factor: A Potential Therapeutic Agent for Parkinson's Disease.
Neuroscience bulletin33(5)568-575(2017 Oct)
Tang T,Li Y,Jiao Q,Du X,Jiang H


book

Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression.
PloS one12(6)e0179476(2017)
Wang L,Wang Z,Zhu R,Bi J,Feng X,Liu W,Wu J,Zhang H,Wu H,Kong W,Yu B,Yu X


book

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.
Behavioural brain research2911-11(2015 Sep)
Kemppainen S,Lindholm P,Galli E,Lahtinen HM,Koivisto H,H?m?l?inen E,Saarma M,Tanila H


book

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against ?-Synuclein Oligomers.
The Journal of biological chemistry290(33)20527-40(2015 Aug)
Latge C,Cabral KM,de Oliveira GA,Raymundo DP,Freitas JA,Johanson L,Rom?o LF,Palhano FL,Herrmann T,Almeida MS,Foguel D