WNT16 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | WNT16 |
| Entrez Gene ID | 51384 |
| Full Name | Wnt family member 16 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_057168.2 | NP_476509.1 | protein Wnt-16 isoform 1 precursor |
| NM_057168.1 | NP_476509.1 | protein Wnt-16 isoform 1 precursor |
| Bos taurus (cattle) | WNT16 | NP_001014949.1 |
| Caenorhabditis elegans (roundworm) | egl-20 | NP_501754.1 |
| Gallus gallus (chicken) | WNT16 | XP_001233678.3 |
| Homo sapiens (human) | WNT16 | NP_476509.1 |
| Pan troglodytes (chimpanzee) | WNT16 | XP_001143972.1 |
| WNT16 | XP_001082781.1 | |
| Mus musculus (house mouse) | Wnt16 | NP_444346.3 |
| Rattus norvegicus (Norway rat) | Wnt16 | NP_001102693.1 |
| Danio rerio (zebrafish) | wnt16 | NP_001093516.1 |
| Xenopus tropicalis (tropical clawed frog) | wnt16 | NP_001096551.1 |
Related articles in PubMed
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes.
Garc?a-Ibarbia C, Neila S, Garc?s C, Alonso MA, Zarrabeitia MT, Valero C, Ortiz F, Riancho JA
Rheumatology international37(10)1667-1672(2017 Oct)
Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma.
DO Carmo NG, Sakamoto LH, Pogue R, DO Couto Mascarenhas C, Passos SK, Felipe MS, DE Andrade RV
Anticancer research36(9)4545-51(2016 09)
Bone morphogenetic protein-induced cell differentiation involves Atg7 and Wnt16 sequentially in human stem cell-derived osteoblastic cells.
Ozeki N, Mogi M, Hase N, Hiyama T, Yamaguchi H, Kawai R, Matsumoto T, Nakata K
Experimental cell research347(1)24-41(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
Title: Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma.
the upregulation of autophagy-related gene (Atg) and wingless/int1 (Wnt) signaling during BMP-2-mediated human osteoblastic differentiation, was examined.
Title: Bone morphogenetic protein-induced cell differentiation involves Atg7 and Wnt16 sequentially in human stem cell-derived osteoblastic cells.
WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3/4/6, a process enhanced by SFRP2, coordinated by the co-receptor LRP6 but subject to abrogation by DKK1.
Title: SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment.
Data indicate that WNT16 is critical for positive regulation of both cortical and trabecular bone mass and structure. WNT16-TG mice exhibited significantly higher whole-body areal bone mineral density and bone mineral content.
Title: Osteoblast-Specific Overexpression of Human WNT16 Increases Both Cortical and Trabecular Bone Mass and Structure in Mice.
loss of endogenous WNT16 results specifically in cortical bone loss, whereas overexpression of WNT16 surprisingly increases mainly trabecular bone mass.
Title: The bone-sparing effects of estrogen and WNT16 are independent of each other.
The following WNT16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WNT16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu13041 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_057168.2 , NM_057168.1 | |
| Accession Version | NM_057168.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2020-01-01 | |
| Organism | Homo sapiens(human) | |
| Product | protein Wnt-16 isoform 1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006364.4. On Nov 26, 2018 this sequence version replaced NM_057168.1. Transcript Variant: This variant (1) differs from variant 2 at the 5' terminus including 5' UTR and the coding region for the N-terminus. Isoform 1, encoded by this variant, is 90% identical to the mouse Wnt16 protein at the amino acid level. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF169963.1, BC104945.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222462.3/ ENSP00000222462.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGACAGGG CGGCGCTCCT GGGACTGGCC CGCTTGTGCG CGCTGTGGGC AGCCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_476509.1 |
| CDS | 294..1391 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_057168.2 |
ORF Insert Sequence:
1 | ATGGACAGGG CGGCGCTCCT GGGACTGGCC CGCTTGTGCG CGCTGTGGGC AGCCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu13041 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_057168.2 , NM_057168.1 | |
| Accession Version | NM_057168.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-09 | |
| Organism | Homo sapiens(human) | |
| Product | protein Wnt-16 isoform 1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF169963.1. Transcript Variant: This variant (1) differs from variant 2 at the 5' terminus including 5' UTR and the coding region for the N-terminus. Isoform 1, encoded by this variant, is 90% identical to the mouse Wnt16 protein at the amino acid level. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF169963.1, SRR1660803.242393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGACAGGG CGGCGCTCCT GGGACTGGCC CGCTTGTGCG CGCTGTGGGC AGCCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_476509.1 |
| CDS | 258..1355 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_057168.1 |
ORF Insert Sequence:
1 | ATGGACAGGG CGGCGCTCCT GGGACTGGCC CGCTTGTGCG CGCTGTGGGC AGCCCTGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes. |
|
Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma. |
|
Bone morphogenetic protein-induced cell differentiation involves Atg7 and Wnt16 sequentially in human stem cell-derived osteoblastic cells. |
