runx3 cDNA ORF clone, Danio rerio(zebrafish)
| Gene Symbol | runx3 |
| Entrez Gene ID | 58127 |
| Full Name | runt-related transcription factor 3 |
| Synonyms | runxb |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Danio rerio(zebrafish) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001362344.1 | NP_001349273.1 | runt-related transcription factor 3 isoform 1 |
| NM_131604.3 | NP_571679.2 | runt-related transcription factor 3 isoform 2 |
| NM_131604.2 | NP_571679.2 | runt-related transcription factor 3 |
| Pan troglodytes (chimpanzee) | RUNX3 | XP_003307937.1 |
| Homo sapiens (human) | RUNX3 | NP_001026850.1 |
| Bos taurus (cattle) | RUNX3 | NP_001180087.1 |
| Mus musculus (house mouse) | Runx3 | NP_062706.2 |
| Xenopus tropicalis (tropical clawed frog) | runx3 | XP_002936643.1 |
| Canis lupus familiaris (dog) | LOC487366 | XP_852730.2 |
| Rattus norvegicus (Norway rat) | Runx3 | NP_569109.1 |
| Danio rerio (zebrafish) | runx3 | NP_571679.2 |
| Gallus gallus (chicken) | RUNX3 | XP_001232978.3 |
Related articles in PubMed
Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing.
Tang Q, Iyer S, Lobbardi R, Moore JC, Chen H, Lareau C, Hebert C, Shaw ML, Neftel C, Suva ML, Ceol CJ, Bernards A, Aryee M, Pinello L, Drummond IA, Langenau DM
The Journal of experimental medicine214(10)2875-2887(2017 Oct)
An ancient neurotrophin receptor code; a single Runx/Cbf? complex determines somatosensory neuron fate specification in zebrafish.
Gau P, Curtright A, Condon L, Raible DW, Dhaka A
PLoS genetics13(7)e1006884(2017 Jul)
Evolutionary and Expression Analyses Show Co-option of
Wang S, Yang Q, Wang Z, Feng S, Li H, Ji D, Zhang S
Frontiers in genetics8225(2017)
CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes.
Dee CT, Nagaraju RT, Athanasiadis EI, Gray C, Fernandez Del Ama L, Johnston SA, Secombes CJ, Cvejic A, Hurlstone AF
Journal of immunology (Baltimore, Md. : 1950)197(9)3520-3530(2016 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 activity.
Title: An ancient neurotrophin receptor code; a single Runx/Cbf? complex determines somatosensory neuron fate specification in zebrafish.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
Title: RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish.
Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development.
Title: Cohesin-dependent regulation of Runx genes.
Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1-expressing cells in the ventral wall of the dorsal aorta.
Title: Runx3 is required for hematopoietic development in zebrafish.
isolation and characterization by spatiotemporal expression detected in the developing zebrafish
Title: Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators.
The following runx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the runx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ODa05287 | |
| Clone ID Related Accession (Same CDS sequence) | NM_131604.2 | |
| Accession Version | NM_131604.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-02 | |
| Organism | Danio rerio(zebrafish) | |
| Product | runt-related transcription factor 3 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF104037.1. On Dec 20, 2003 this sequence version replaced NM_131604.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF104037.1 [ECO:0000332] ##Evidence-Data-END## | |
1 | ATGCATATTC CCGTAGACCC GAGCACGAGC AGACGGTTCA CGCCGCCCTC CGCCTCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_571679.2 |
| CDS | 60..1334 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_131604.2 |
ORF Insert Sequence:
1 | ATGCATATTC CCGTAGACCC GAGCACGAGC AGACGGTTCA CGCCGCCCTC CGCCTCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ODa159840 | |
| Clone ID Related Accession (Same CDS sequence) | NM_131604.3 | |
| Accession Version | NM_131604.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-14 | |
| Organism | Danio rerio(zebrafish) | |
| Product | runt-related transcription factor 3 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CABZ01083960.1 and CT025744.6. On Apr 12, 2018 this sequence version replaced NM_131604.2. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043788.1, BC163552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCATATTC CCGTAGACCC GAGCACGAGC AGACGGTTCA CGCCGCCCTC CGCCTCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_571679.2 |
| CDS | 568..1842 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_131604.3 |
ORF Insert Sequence:
1 | ATGCATATTC CCGTAGACCC GAGCACGAGC AGACGGTTCA CGCCGCCCTC CGCCTCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ODa159874 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001362344.1 | |
| Accession Version | NM_001362344.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-14 | |
| Organism | Danio rerio(zebrafish) | |
| Product | runt-related transcription factor 3 isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CABZ01078998.1, CABZ01083960.1 and CT025744.6. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168447, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCTTCAA ACAGCATCTT CGACACATTC TCTAGCTACT CGCCCAGTTT GCTGCGAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001349273.1 |
| CDS | 131..1447 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001362344.1 |
ORF Insert Sequence:
1 | ATGGCTTCAA ACAGCATCTT CGACACATTC TCTAGCTACT CGCCCAGTTT GCTGCGAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. |
|
An ancient neurotrophin receptor code; a single Runx/Cbf? complex determines somatosensory neuron fate specification in zebrafish. |
|
Evolutionary and Expression Analyses Show Co-option of |
|
CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. |