| Gene Symbol | Kank2 |
| Entrez Gene ID | 100361376 |
| Full Name | KN motif and ankyrin repeat domains 2 |
| Synonyms | RGD1563532 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
The following Kank2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kank2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa09251 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001270413.1 | |
| Accession Version | NM_001270413.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | KN motif and ankyrin repeat domain-containing protein 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC119556.5. On Jul 4, 2012 this sequence version replaced XM_002729875.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689599, SAMN02642809 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGCCA AGCCTCCTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001257342.1 |
| CDS | 160..2682 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001270413.1 |
1 | ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGCCA AGCCTCCTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa30874 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006242589.3 , XM_006242590.3 | |
| Accession Version | XM_006242589.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | KN motif and ankyrin repeat domain-containing protein 2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242589.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGCCA AGCCTCCTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006242651.1 |
| CDS | 541..3084 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006242589.3 |
1 | ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGCCA AGCCTCCTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa30874 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006242589.3 , XM_006242590.3 | |
| Accession Version | XM_006242590.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | KN motif and ankyrin repeat domain-containing protein 2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242590.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGCCA AGCCTCCTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006242652.1 |
| CDS | 396..2939 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006242590.3 |
1 | ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGCCA AGCCTCCTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. |
Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair. |
Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria. |
SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. |
