Nr2f2 cDNA ORF clone, Rattus norvegicus(Norway rat)
Gene Symbol | Nr2f2 |
Entrez Gene ID | 113984 |
Full Name | nuclear receptor subfamily 2, group F, member 2 |
Synonyms | Tfcoup2 |
General protein information |
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Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | transcriptional activator or repressor; involved in determining the metabolic phenotype of hepatic cells [RGD, Feb 2006]. |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_080778.2 | NP_542956.1 | COUP transcription factor 2 |
XM_006229366.3 | XP_006229428.1 | COUP transcription factor 2 isoform X1 |
XM_017588643.1 | XP_017444132.1 | COUP transcription factor 2 isoform X2 |

Mus musculus (house mouse) | Nr2f2 | NP_033827.2 |
Drosophila melanogaster (fruit fly) | svp | NP_524325.1 |
Homo sapiens (human) | NR2F2 | NP_066285.1 |
NR2F2 | XP_001099957.1 | |
Pan troglodytes (chimpanzee) | NR2F2 | XP_003952785.1 |
Canis lupus familiaris (dog) | NR2F2 | XP_005618373.1 |
Bos taurus (cattle) | NR2F2 | NP_776827.1 |
Rattus norvegicus (Norway rat) | Nr2f2 | NP_542956.1 |
Gallus gallus (chicken) | NR2F2 | NP_989752.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002544 | XP_312394.4 |
Xenopus tropicalis (tropical clawed frog) | nr2f2 | NP_001107703.1 |
Danio rerio (zebrafish) | nr2f2 | NP_571258.1 |

Related articles in PubMed
Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension.
Kumarasamy S, Waghulde H, Gopalakrishnan K, Mell B, Morgan E, Joe B
Nature communications66252(2015 Feb)
The expression of Apoc3 mRNA is regulated by HNF4? and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells.
Howell M, Li R, Zhang R, Li Y, Chen W, Chen G
Molecular and cellular biochemistry387(1-2)241-50(2014 Feb)
Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells.
Kim BJ, Scott DA
PloS one9(1)e87518(2014)
Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.
Tornari C, Towers ER, Gale JE, Dawson SJ
PloS one9(11)e112247(2014)
Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.
Li Y, Xia Y, Wang Y, Mao L, Gao Y, He Q, Huang M, Chen S, Hu B
Molecular neurobiology47(3)967-75(2013 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nr2f2 mutation in the hinge region attenuates salt-sensitive hypertension
Title: Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension.
Apoc3 expression is regulated by HNF4a and COUP-TFII but not by retinoic acid in rat hepatocytes.
Title: The expression of Apoc3 mRNA is regulated by HNF4? and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells.
These data demonstrate that Nr2f2 is a direct target of POU4F3 in vitro and that this regulatory relationship may be relevant to hair cell development and survival.
Title: Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.
oxygen-glucose deprivation could induce the expressions of VEGF, Ang-1, and Ang-2, with the expression of Shh signaling components increased.
Title: Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.
Upregulation of COUP-II gene expression in the PPF may contribute to the diaphragmatic defect in the nitrofen congenital diaphragmatic hernia rat model by inhibiting the RSP.
Title: COUP-TFII gene expression is upregulated in embryonic pleuroperitoneal folds in the nitrofen-induced congenital diaphragmatic hernia rat model.
The following Nr2f2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nr2f2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa22897 | |
Clone ID Related Accession (Same CDS sequence) | XM_006229366.3 | |
Accession Version | XM_006229366.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | COUP transcription factor 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229366.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAAGCGG TTTGGGACCT TGAACAAGGC AAATATGGTT TTGCTGTACA GAGGGGCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006229428.1 |
CDS | 5475..6320 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGCAAGCGG TTTGGGACCT TGAACAAGGC AAATATGGTT TTGCTGTACA GAGGGGCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa56291 | |
Clone ID Related Accession (Same CDS sequence) | XM_017588643.1 | |
Accession Version | XM_017588643.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | COUP transcription factor 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCGCCCA CCCAGCCTAC TCACGGGCAG TTTGCACTGA CCAACGGGGA CCCCCTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017444132.1 |
CDS | 96..881 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGCCGCCCA CCCAGCCTAC TCACGGGCAG TTTGCACTGA CCAACGGGGA CCCCCTCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa00175 | |
Clone ID Related Accession (Same CDS sequence) | NM_080778.2 | |
Accession Version | NM_080778.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | COUP transcription factor 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF003944.1. On Aug 31, 2012 this sequence version replaced NM_080778.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF003944.1, EV770714.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906351, SAMN01906357 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAATGG TAGTCAGCAC GTGGCGCGAC CCCCAGGACG AGGTGCCCGG CTCTCAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_542956.1 |
CDS | 185..1429 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCAATGG TAGTCAGCAC GTGGCGCGAC CCCCAGGACG AGGTGCCCGG CTCTCAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. |
![]() |
The expression of Apoc3 mRNA is regulated by HNF4? and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells. |
![]() |
Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. |
![]() |
Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3. |
![]() |
Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2. |