Calcr cDNA ORF clone, Rattus norvegicus(Norway rat)
Gene Symbol | Calcr |
Entrez Gene ID | 116506 |
Full Name | calcitonin receptor |
General protein information |
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Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | receptor for calcitonin; acts via adenylate cyclase signaling [RGD, Feb 2006]. |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_053816.2 | NP_446268.2 | calcitonin receptor isoform 1b precursor |
NM_001034015.1 | NP_001029187.1 | calcitonin receptor isoform 1a precursor |

Canis lupus familiaris (dog) | CALCR | NP_001184071.1 |
CALCR | XP_001099544.2 | |
Danio rerio (zebrafish) | calcr | XP_003200679.2 |
Homo sapiens (human) | CALCR | NP_001158209.1 |
Pan troglodytes (chimpanzee) | CALCR | XP_001167949.1 |
Bos taurus (cattle) | CALCR | NP_001069737.2 |
Mus musculus (house mouse) | Calcr | NP_031614.2 |
Rattus norvegicus (Norway rat) | Calcr | NP_446268.2 |
Gallus gallus (chicken) | CALCR | XP_425985.3 |
Xenopus tropicalis (tropical clawed frog) | calcr | XP_002934645.2 |

Related articles in PubMed
A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats.
Andreassen KV, Feigh M, Hjuler ST, Gydesen S, Henriksen JE, Beck-Nielsen H, Christiansen C, Karsdal MA, Henriksen K
American journal of physiology. Endocrinology and metabolism307(1)E24-33(2014 Jul)
Decline in calcitonin receptor expression in osteocytes with age.
Gooi JH, Chia LY, Walsh NC, Karsdal MA, Quinn JM, Martin TJ, Sims NA
The Journal of endocrinology221(2)181-91(2014 May)
Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women.
Tural S, Kara N, Alayli G, Tomak L
Gene515(1)167-72(2013 Feb)
Amyloid ? (A?) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways.
Fu W, Ruangkittisakul A, MacTavish D, Shi JY, Ballanyi K, Jhamandas JH
The Journal of biological chemistry287(22)18820-30(2012 May)
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.
Abdelmagid N, Bereczky-Veress B, Guerreiro-Cacais AO, Bergman P, Luhr KM, Bergstr?m T, Sk?ldenberg B, Piehl F, Olsson T, Diez M
PLoS pathogens8(6)e1002753(2012)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In conclusion, oral KBP-042 is a novel DACRA, which exerts antiobesity and antidiabetic efficacy by dual modulation of insulin sensitivity and directly decelerating stress on the pancreatic alpha- and beta-cells.
Title: A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats.
Calcitonin receptor mRNA expression declines with age on osteocytes.
Title: Decline in calcitonin receptor expression in osteocytes with age.
variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent Herpes simplex encephalitis development.
Title: The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.
RAMP interaction with the CTRa in COS-7 or HEK-293 cells leads to selective modulation of signaling pathways activated by the receptor complex.
Title: Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors.
Abundant expression of calcitonin C1 receptors was found in the nucleus accumbens, lateral arcuate nucleus, lateral substantia nigra, bed nucleus, locus coeruleus, area postrema, nucleus of the solitary tract, and some nuclei of the reticular formation.
Title: Immunohistochemical mapping of calcitonin receptors in the adult rat brain.
The following Calcr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Calcr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa08829 | |
Clone ID Related Accession (Same CDS sequence) | NM_001034015.1 | |
Accession Version | NM_001034015.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcitonin receptor isoform 1a precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB791100.1 and L14617.1. Transcript Variant: This variant (1a, previously called 2), lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a, previously called b), has the same N- and C-termini but is shorter compared to isoform 1b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L13041.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMEA2689595 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACTCCAC GGAGATCCAG AATGAAAAGG CGGAACCTCC GAAAACCGAA GATGAGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001029187.1 |
CDS | 242..1732 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGACTCCAC GGAGATCCAG AATGAAAAGG CGGAACCTCC GAAAACCGAA GATGAGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa10734 | |
Clone ID Related Accession (Same CDS sequence) | NM_053816.2 | |
Accession Version | NM_053816.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1602bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-15 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcitonin receptor isoform 1b precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB791100.1, L14618.1 and L14617.1. On Oct 9, 2005 this sequence version replaced NM_053816.1. Transcript Variant: This variant (1b), previously called 1, represents the longer variant and encodes the longer isoform (1b, previously called a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMEA2689595 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACTCCAC GGAGATCCAG AATGAAAAGG CGGAACCTCC GAAAACCGAA GATGAGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_446268.2 |
CDS | 242..1843 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGACTCCAC GGAGATCCAG AATGAAAAGG CGGAACCTCC GAAAACCGAA GATGAGGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats. |
![]() |
Decline in calcitonin receptor expression in osteocytes with age. |
![]() |
Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women. |
![]() |
Amyloid ? (A?) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. |
![]() |
The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |