Cpa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cpa1
Entrez Gene ID	24269
Full Name	carboxypeptidase A1
General protein information	Preferred Names carboxypeptidase A1 Names carboxypeptidase A1 carboxypeptidase A1 (pancreatic)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q22
Summary	putative carboxypeptidase A protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_016998.3	NP_058694.2	carboxypeptidase A1 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CPA1	XP_005628437.1
Bos taurus (cattle)	CPA1	NP_777175.1
Mus musculus (house mouse)	Cpa1	NP_079626.2
	CPA1	XP_001096893.1
Rattus norvegicus (Norway rat)	Cpa1	NP_058694.2
Gallus gallus (chicken)	CPA1	NP_989915.1
Danio rerio (zebrafish)	cpa5	NP_954965.1
Drosophila melanogaster (fruit fly)	CG17633	NP_609310.2
Anopheles gambiae (African malaria mosquito)	CBPA1_ANOGA	XP_318615.2
Homo sapiens (human)	CPA1	NP_001859.1
Danio rerio (zebrafish)	cpa1	NP_001018318.1
Pan troglodytes (chimpanzee)	CPA1	XP_003318844.1
Xenopus tropicalis (tropical clawed frog)	cpa1	NP_001107681.1

Gene Ontology
Bibliography

Related articles in PubMed

Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides.
Pereira HJ, Souza LL, Costa-Neto CM, Salgado MC, Oliveira EB
Peptides33(1)67-76(2012 Jan)

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.
K?hlein HN, Tegeder I, M?ser C, Lim HY, H?ussler A, Spieth K, Jennes I, Marschalek R, Beckhaus T, Karas M, Fauth M, Ehnert C, Geisslinger G, Niederberger E
PloS one6(4)e19270(2011 Apr)

Changes in carboxypeptidase A, dipeptidase and Na+/K+ ATPase activities in the intestine of rats orally exposed to different doses of cadmium.
Eriyamremu GE, Asagba SO, Onyeneke EC, Adaikpoh MA
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine18(1)1-6(2005 Feb)

Gene expression profile in rat small intestinal allografts after cold preservation/reperfusion.
Wang SF, Liang Q, Li GW, Gao K
World journal of gastroenterology11(6)885-9(2005 Feb)

Rat preprocarboxypeptidase A: cDNA sequence and preliminary characterization of the gene.
Quinto C, Quiroga M, Swain WF, Nikovits WC Jr, Standring DN, Pictet RL, Valenzuela P, Rutter WJ
Proceedings of the National Academy of Sciences of the United States of America79(1)31-5(1982 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

gene transcripts for CPA1 in mesentery and other extrapancreatic tissues indicate that CPA1 might play a role in the renin-angiotensin system in addition to it'sfunction as digestive enzyme
Title: Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides.

Data show that latexin protein expression was reduced after SNI, and the decrease of latexin was associated with an increase of the activity of carboxypeptidase A.
Title: Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

carboxypeptidase A, dipeptidase and Na+/K+ ATPase levels in the rat intestine change when exposed to different doses of cadmium
Title: Changes in carboxypeptidase A, dipeptidase and Na+/K+ ATPase activities in the intestine of rats orally exposed to different doses of cadmium.

The following Cpa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cpa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02441	NM_016998.3 Latest version!	Rattus norvegicus carboxypeptidase A1 (Cpa1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cpa1 ( NM_016998.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058694.2 Rattus norvegicus carboxypeptidase A1 (Cpa1), mRNA.

Price & Availability↑

CloneID	ORa02441
Clone ID Related Accession (Same CDS sequence)	NM_016998.3
Accession Version	NM_016998.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	carboxypeptidase A1 preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC107243.6. On May 14, 2011 this sequence version replaced NM_016998.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: J00713.1, FQ233540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGAC TACTGATTCT GAGTCTGCTG CTGGAAGCAG TCTGTGGCAA TGAGAACTTT 
GTGGGACACC AGGTTCTCCG AATCTCTGCA GCCGATGAAG CCCAGGTGCA GAAAGTGAAG 
GAGTTGGAGG ACCTGGAGCA CTTGCAGTTG GACTTCTGGC GGGACGCTGC CCGGGCCGGT 
ATCCCCATTG ATGTCAGAGT GCCCTTCCCC AGCATCCAAT CTGTGAAAGC ATTCTTGGAA 
TATCATGGTA TTAGCTATGA GATCATGATT GAAGATGTGC AGTTACTGCT CGATGAGGAG 
AAACAGCAGA TGTCTGCCTT CCAGGCCAGG GCCTTGTCCA CTGACTCTTT CAATTATGCC 
ACCTATCATA CGCTGGATGA GATCTACGAA TTCATGGACC TGCTGGTGGC TGAGCACCCA 
CAGCTTGTGA GCAAGATCCA GATCGGCAAC ACCTTTGAAG GTCGCCCCAT CCATGTGCTG 
AAGTTCAGCA CTGGAGGGAC CAATCGCCCA GCAATCTGGA TCGACACTGG CATCCATTCT 
AGGGAGTGGG TCACCCAGGC TAGTGGGGTC TGGTTTGCAA AGAAGATCAC CAAAGACTAT 
GGCCAGGACC CCACCTTCAC AGCCGTTCTT GACAACATGG ACATCTTCCT GGAGATTGTC 
ACCAACCCTG ATGGTTTTGC CTACACCCAC AAAACGAATC GCATGTGGCG CAAGACTCGA 
TCACACACCC AGGGCTCCCT CTGTGTTGGT GTGGACCCCA ACAGGAACTG GGACGCTGGC 
TTTGGGATGG CCGGAGCAAG TAGCAACCCC TGCTCGGAAA CTTACCGAGG CAAATTTCCC 
AACTCTGAGG TGGAGGTCAA GTCCATCGTG GACTTTGTGA CGAGCCATGG GAACATCAAG 
GCCTTCATCT CCATCCACAG CTATTCCCAG CTCCTGCTCT ACCCCTACGG CTACACGTCG 
GAACCAGCCC CTGACCAGGC AGAGCTGGAT CAGCTAGCTA AGTCTGCTGT GACAGCCTTG 
ACGTCTCTAC ACGGGACCAA GTTCAAGTAT GGCAGCATCA TCGATACAAT CTATCAAGCC 
AGTGGGAGCA CTATCGATTG GACCTACAGC CAGGGCATCA AGTACTCTTT CACTTTTGAA 
CTGAGGGACA CTGGGCTTAG AGGATTCCTG CTGCCTGCCT CCCAGATCAT CCCTACGGCG 
GAGGAGACAT GGCTGGCCCT TTTGACCATC ATGGACCACA CAGTCAAACA CCCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058694.2
CDS	309..1568
Translation	MKRLLILSLLLEAVCGNENFVGHQVLRISAADEAQVQKVKELEDLEHLQLDFWRDAARAGIPIDVRVPFPSIQSVKAFLEYHGISYEIMIEDVQLLLDEEKQQMSAFQARALSTDSFNYATYHTLDEIYEFMDLLVAEHPQLVSKIQIGNTFEGRPIHVLKFSTGGTNRPAIWIDTGIHSREWVTQASGVWFAKKITKDYGQDPTFTAVLDNMDIFLEIVTNPDGFAYTHKTNRMWRKTRSHTQGSLCVGVDPNRNWDAGFGMAGASSNPCSETYRGKFPNSEVEVKSIVDFVTSHGNIKAFISIHSYSQLLLYPYGYTSEPAPDQAELDQLAKSAVTALTSLHGTKFKYGSIIDTIYQASGSTIDWTYSQGIKYSFTFELRDTGLRGFLLPASQIIPTAEETWLALLTIMDHTVKHPY

Target ORF information:

RefSeq Version	NM_016998.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus carboxypeptidase A1 (Cpa1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016998.3

ORF Insert Sequence:

ATGAAGAGAC TACTGATTCT GAGTCTGCTG CTGGAAGCAG TCTGTGGCAA TGAGAACTTT 
GTGGGACACC AGGTTCTCCG AATCTCTGCA GCCGATGAAG CCCAGGTGCA GAAAGTGAAG 
GAGTTGGAGG ACCTGGAGCA CTTGCAGTTG GACTTCTGGC GGGACGCTGC CCGGGCCGGT 
ATCCCCATTG ATGTCAGAGT GCCCTTCCCC AGCATCCAAT CTGTGAAAGC ATTCTTGGAA 
TATCATGGTA TTAGCTATGA GATCATGATT GAAGATGTGC AGTTACTGCT CGATGAGGAG 
AAACAGCAGA TGTCTGCCTT CCAGGCCAGG GCCTTGTCCA CTGACTCTTT CAATTATGCC 
ACCTATCATA CGCTGGATGA GATCTACGAA TTCATGGACC TGCTGGTGGC TGAGCACCCA 
CAGCTTGTGA GCAAGATCCA GATCGGCAAC ACCTTTGAAG GTCGCCCCAT CCATGTGCTG 
AAGTTCAGCA CTGGAGGGAC CAATCGCCCA GCAATCTGGA TCGACACTGG CATCCATTCT 
AGGGAGTGGG TCACCCAGGC TAGTGGGGTC TGGTTTGCAA AGAAGATCAC CAAAGACTAT 
GGCCAGGACC CCACCTTCAC AGCCGTTCTT GACAACATGG ACATCTTCCT GGAGATTGTC 
ACCAACCCTG ATGGTTTTGC CTACACCCAC AAAACGAATC GCATGTGGCG CAAGACTCGA 
TCACACACCC AGGGCTCCCT CTGTGTTGGT GTGGACCCCA ACAGGAACTG GGACGCTGGC 
TTTGGGATGG CCGGAGCAAG TAGCAACCCC TGCTCGGAAA CTTACCGAGG CAAATTTCCC 
AACTCTGAGG TGGAGGTCAA GTCCATCGTG GACTTTGTGA CGAGCCATGG GAACATCAAG 
GCCTTCATCT CCATCCACAG CTATTCCCAG CTCCTGCTCT ACCCCTACGG CTACACGTCG 
GAACCAGCCC CTGACCAGGC AGAGCTGGAT CAGCTAGCTA AGTCTGCTGT GACAGCCTTG 
ACGTCTCTAC ACGGGACCAA GTTCAAGTAT GGCAGCATCA TCGATACAAT CTATCAAGCC 
AGTGGGAGCA CTATCGATTG GACCTACAGC CAGGGCATCA AGTACTCTTT CACTTTTGAA 
CTGAGGGACA CTGGGCTTAG AGGATTCCTG CTGCCTGCCT CCCAGATCAT CCCTACGGCG 
GAGGAGACAT GGCTGGCCCT TTTGACCATC ATGGACCACA CAGTCAAACA CCCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides.
Peptides33(1)67-76(2012 Jan)
Pereira HJ,Souza LL,Costa-Neto CM,Salgado MC,Oliveira EB

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.
PloS one6(4)e19270(2011 Apr)
K?hlein HN,Tegeder I,M?ser C,Lim HY,H?ussler A,Spieth K,Jennes I,Marschalek R,Beckhaus T,Karas M,Fauth M,Ehnert C,Geisslinger G,Niederberger E

Changes in carboxypeptidase A, dipeptidase and Na+/K+ ATPase activities in the intestine of rats orally exposed to different doses of cadmium.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine18(1)1-6(2005 Feb)
Eriyamremu GE,Asagba SO,Onyeneke EC,Adaikpoh MA

Gene expression profile in rat small intestinal allografts after cold preservation/reperfusion.
World journal of gastroenterology11(6)885-9(2005 Feb)
Wang SF,Liang Q,Li GW,Gao K

Rat preprocarboxypeptidase A: cDNA sequence and preliminary characterization of the gene.
Proceedings of the National Academy of Sciences of the United States of America79(1)31-5(1982 Jan)
Quinto C,Quiroga M,Swain WF,Nikovits WC Jr,Standring DN,Pictet RL,Valenzuela P,Rutter WJ

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Cpa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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