Ifnb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ifnb1
Entrez Gene ID	24481
Full Name	interferon beta 1
Synonyms	Ifnb
General protein information	Preferred Names interferon beta 1 Names interferon beta IFN-beta interferon beta 1, fibroblast
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q32
Summary	suppresses the growth of rat glioma cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019127.1	NP_062000.1	interferon beta precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IFNB1	XP_528553.1
Canis lupus familiaris (dog)	IFNB1	NP_001129259.1
Rattus norvegicus (Norway rat)	Ifnb1	NP_062000.1
Homo sapiens (human)	IFNB1	NP_002167.1
	IFNB1	NP_001129267.1
Mus musculus (house mouse)	Ifnb1	NP_034640.1

Gene Ontology
Bibliography

Related articles in PubMed

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene.
Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB, Zhong B
The Journal of biological chemistry291(25)13206-15(2016 Jun)

Bone marrow-derived mesenchymal stem cells co-expressing interleukin-18 and interferon-? exhibit potent antitumor effect against intracranial glioma in rats.
Xu G, Guo Y, Seng Z, Cui G, Qu J
Oncology reports34(4)1915-22(2015 Oct)

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response.
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Mart?nez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, Garc?a-Sastre A
Immunity40(6)880-95(2014 Jun)

Structural basis of a unique interferon-? signaling axis mediated via the receptor IFNAR1.
de Weerd NA, Vivian JP, Nguyen TK, Mangan NE, Gould JA, Braniff SJ, Zaker-Tabrizi L, Fung KY, Forster SC, Beddoe T, Reid HH, Rossjohn J, Hertzog PJ
Nature immunology14(9)901-7(2013 Sep)

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation.
Bhattacharyya S, Zhao Y, Kay TW, Muglia LJ
Proceedings of the National Academy of Sciences of the United States of America108(23)9554-9(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results provided evidence that delivery of IL-18 and IFN-beta by BMSCs may be an excellent and promising approach to develop an effective treatment protocol for glioma therapy.
Title: Bone marrow-derived mesenchymal stem cells co-expressing interleukin-18 and interferon-? exhibit potent antitumor effect against intracranial glioma in rats.

IFN-gamma is able to activate rat intestinal mucous microvascular endothelial cells, thereby leading to upregulated expressions of IFN-alpha/beta.
Title: IFN-? induces IFN-? and IFN-? expressions in cultured rat intestinal mucosa microvascular endothelial cells.

This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons.
Title: Interferon-beta modulates protein synthesis in the central nervous system.

These findings validate IFN-beta as a therapeutic molecule for intraarticular gene therapy of arthritis.
Title: Intraarticular interferon-beta gene therapy ameliorates adjuvant arthritis in rats.

The following Ifnb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ifnb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42508	NM_019127.1 Latest version!	Rattus norvegicus interferon beta 1 (Ifnb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ifnb1 ( NM_019127.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062000.1 Rattus norvegicus interferon beta 1 (Ifnb1), mRNA.

Price & Availability↑

CloneID	ORa42508
Clone ID Related Accession (Same CDS sequence)	NM_019127.1
Accession Version	NM_019127.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	interferon beta precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D87919.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCCAACA GGTGGACCCT CCACATTGCG TTCCTGCTGT GCTTCTCCAC CACTGCCCTC 
TCCATCGACT ACAAGCAGCT CCAGTTCCGA CAAAGCACTA GCATTCGGAC ATGTCAGAAG 
CTCCTGAGGC AGCTGAATGG AAGGCTCAAC CTCAGCTACA GGACGGACTT CAAGATCCCT 
ATGGAGGTGA TGCACCCGTC ACAGATGGAG AAGAGTTACA CTGCCTTTGC CATTCAAGTG 
ATGCTCCAGA ATGTCTTTCT TGTCTTCAGA AGCAATTTCT CCAGCACTGG GTGGAATGAG 
ACTATTGTTG AAAGTCTCTT GGATGAACTA CATCAGCAGA CAGAGCTTCT GGAGATAATA 
CTAAAGGAAA AGCAAGAGGA AAGATTGACT TGGGTGACAT CCACGACTAC TTTAGGCTTG 
AAGAGCTATT ACTGGAGGGT ACAAAGGTAC CTTAAAGACA AGAAGTACAA CAGCTATGCC 
TGGATGGTGG TCCGAGCAGA AGTCTTCAGG AACTTTTCCA TTATTCTAAG ACTTAATAGA 
AACTTCCAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062000.1
CDS	1..555
Translation	MANRWTLHIAFLLCFSTTALSIDYKQLQFRQSTSIRTCQKLLRQLNGRLNLSYRTDFKIPMEVMHPSQMEKSYTAFAIQVMLQNVFLVFRSNFSSTGWNETIVESLLDELHQQTELLEIILKEKQEERLTWVTSTTTLGLKSYYWRVQRYLKDKKYNSYAWMVVRAEVFRNFSIILRLNRNFQN

Target ORF information:

RefSeq Version	NM_019127.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interferon beta 1 (Ifnb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019127.1

ORF Insert Sequence:

ATGGCCAACA GGTGGACCCT CCACATTGCG TTCCTGCTGT GCTTCTCCAC CACTGCCCTC 
TCCATCGACT ACAAGCAGCT CCAGTTCCGA CAAAGCACTA GCATTCGGAC ATGTCAGAAG 
CTCCTGAGGC AGCTGAATGG AAGGCTCAAC CTCAGCTACA GGACGGACTT CAAGATCCCT 
ATGGAGGTGA TGCACCCGTC ACAGATGGAG AAGAGTTACA CTGCCTTTGC CATTCAAGTG 
ATGCTCCAGA ATGTCTTTCT TGTCTTCAGA AGCAATTTCT CCAGCACTGG GTGGAATGAG 
ACTATTGTTG AAAGTCTCTT GGATGAACTA CATCAGCAGA CAGAGCTTCT GGAGATAATA 
CTAAAGGAAA AGCAAGAGGA AAGATTGACT TGGGTGACAT CCACGACTAC TTTAGGCTTG 
AAGAGCTATT ACTGGAGGGT ACAAAGGTAC CTTAAAGACA AGAAGTACAA CAGCTATGCC 
TGGATGGTGG TCCGAGCAGA AGTCTTCAGG AACTTTTCCA TTATTCTAAG ACTTAATAGA 
AACTTCCAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene.
The Journal of biological chemistry291(25)13206-15(2016 Jun)
Ren Y,Zhao Y,Lin D,Xu X,Zhu Q,Yao J,Shu HB,Zhong B

Bone marrow-derived mesenchymal stem cells co-expressing interleukin-18 and interferon-? exhibit potent antitumor effect against intracranial glioma in rats.
Oncology reports34(4)1915-22(2015 Oct)
Xu G,Guo Y,Seng Z,Cui G,Qu J

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response.
Immunity40(6)880-95(2014 Jun)
Rajsbaum R,Versteeg GA,Schmid S,Maestre AM,Belicha-Villanueva A,Mart?nez-Romero C,Patel JR,Morrison J,Pisanelli G,Miorin L,Laurent-Rolle M,Moulton HM,Stein DA,Fernandez-Sesma A,tenOever BR,Garc?a-Sastre A

Structural basis of a unique interferon-? signaling axis mediated via the receptor IFNAR1.
Nature immunology14(9)901-7(2013 Sep)
de Weerd NA,Vivian JP,Nguyen TK,Mangan NE,Gould JA,Braniff SJ,Zaker-Tabrizi L,Fung KY,Forster SC,Beddoe T,Reid HH,Rossjohn J,Hertzog PJ

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation.
Proceedings of the National Academy of Sciences of the United States of America108(23)9554-9(2011 Jun)
Bhattacharyya S,Zhao Y,Kay TW,Muglia LJ

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Ifnb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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