Myc cDNA ORF clone, Rattus norvegicus(Norway rat)
Gene Symbol | Myc |
Entrez Gene ID | 24577 |
Full Name | MYC proto-oncogene, bHLH transcription factor |
Synonyms | RNCMYC,c-myc,mMyc |
General protein information |
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Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome | |
Summary | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008]. |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_012603.2 | NP_036735.2 | myc proto-oncogene protein |

Bos taurus (cattle) | MYC | NP_001039539.1 |
Xenopus tropicalis (tropical clawed frog) | MGC76254 | NP_989390.1 |
Mus musculus (house mouse) | Myc | NP_034979.3 |
Homo sapiens (human) | MYC | NP_002458.2 |
Pan troglodytes (chimpanzee) | MYC | NP_001136266.1 |
Rattus norvegicus (Norway rat) | Myc | NP_036735.2 |
MYC | NP_001136345.1 | |
Danio rerio (zebrafish) | mycb | NP_956466.1 |
Canis lupus familiaris (dog) | MYC | NP_001003246.2 |
Gallus gallus (chicken) | MYC | NP_001026123.1 |
Danio rerio (zebrafish) | myca | NP_571487.2 |

Related articles in PubMed
WNT10A/??catenin pathway in tumorigenesis of papillary thyroid carcinoma.
Dong T, Zhang Z, Zhou W, Zhou X, Geng C, Chang LK, Tian X, Liu S
Oncology reports38(2)1287-1294(2017 Aug)
Down-regulation of the klf5-c-Myc interaction due to klf5 phosphorylation mediates resveratrol repressing the caveolin-1 transcription through the PI3K/PKD1/Akt pathway.
Yang H, Chen Q, Sun F, Zhao N, Wen L, Li L, Ran G
PloS one12(12)e0189156(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
loss of inhibition on c-myc-Bmi-1-p16 signaling pathway by let-7g may lead to PASMCs proliferation and vascular remodeling in pulmonary hypertension
Title: MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G
demonstrated that RSV activated klf5 phosphorylation by inhibiting PI3K/PKD1/Akt pathway, and then attenuated the interaction of klf5 with c-Myc
Title: Down-regulation of the klf5-c-Myc interaction due to klf5 phosphorylation mediates resveratrol repressing the caveolin-1 transcription through the PI3K/PKD1/Akt pathway.
By inducing Myc expression in the colonic epithelium, lithium promotes colonic regeneration after DSS-induced colitis.
Title: A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice.
JNK1 mediates pancreatic beta apoptotic cell death associated with increased Myc expression in IL1-beta treated cells.
Title: JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1?-Induced Apoptosis Associated with Abrogated Myc Expression.
Glucagon phosphorylates serine 552 of beta-catenin leading to increased expression of Ccnd1 and c-Myc in the isolated rat liver.
Title: Glucagon phosphorylates serine 552 of ?-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.
The following Myc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa13490 | |
Clone ID Related Accession (Same CDS sequence) | NM_012603.2 | |
Accession Version | NM_012603.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-03 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | myc proto-oncogene protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY679730.1. On Aug 23, 2004 this sequence version replaced NM_012603.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY679730.1, BC091699.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | CTGAATTTCC TTTGGGAGGT GGAAAACCCG ACAGTCACGA CGATGCCCCT CAACGTGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_036735.2 |
CDS | 537..1898 |
Translation |

Target ORF information:
Target ORF information:
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ORF Insert Sequence:
1 | CTGAATTTCC TTTGGGAGGT GGAAAACCCG ACAGTCACGA CGATGCCCCT CAACGTGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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WNT10A/??catenin pathway in tumorigenesis of papillary thyroid carcinoma. |
![]() |
Down-regulation of the klf5-c-Myc interaction due to klf5 phosphorylation mediates resveratrol repressing the caveolin-1 transcription through the PI3K/PKD1/Akt pathway. |