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Myl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Myl3
Entrez Gene ID 24585
Full Name myosin light chain 3
Synonyms MLClV,Mylc1v,rVMLC1
General protein information
Preferred Names

myosin light chain 3

Names

myosin light chain 3
MLC1SB
Myosin light chain 3, alkali, cardiac ventricles
myosin alkali light chain 1, ventricular
myosin light chain 1, slow-twitch muscle B/ventricular isoform
myosin, light chain 3, alkali
myosin, light chain 3, alkali; ventricular, skeletal, slow
myosin, light polypeptide 3
ventricular myosin light chain 1
ventricular, skeletal, slow
ventricular/slow twitch myosin alkali light chain
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

8

8q32
Summary predominant myosin light chain in cardiac tissue [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_012606.2 NP_036738.1 myosin light chain 3
XM_006243917.3 XP_006243979.3 myosin light chain 3 isoform X1

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Myl3 NP_034989.1
Homo sapiens (human) MYL3 NP_000249.1
MYL3 XP_001113910.1
Gallus gallus (chicken) MYL3 NP_990490.1
Pan troglodytes (chimpanzee) LOC460327 XP_003309811.2
Bos taurus (cattle) MYL3 NP_001069969.2
Danio rerio (zebrafish) zgc:66286 NP_956810.1
Xenopus tropicalis (tropical clawed frog) myl3 NP_989012.1
Canis lupus familiaris (dog) MYL3 XP_005632679.1
Rattus norvegicus (Norway rat) Myl3 NP_036738.1

Gene Ontology


Bibliography

Related articles in PubMed

The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.
Zhong S, Thompson LV
American journal of physiology. Cell physiology293(2)C723-8(2007 Aug)

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Morita H, Larson MG, Barr SC, Vasan RS, O'Donnell CJ, Hirschhorn JN, Levy D, Corey D, Seidman CE, Seidman JG, Benjamin EJ
Circulation113(23)2697-705(2006 Jun)

Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats.
Haase H, Dobbernack G, T?nnemann G, Karczewski P, Cardoso C, Petzhold D, Schlegel WP, Lutter S, Pierschalek P, Behlke J, Morano I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(7)865-73(2006 May)

Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Yamashita H, Sugiura S, Fujita H, Yasuda Si, Nagai R, Saeki Y, Sunagawa K, Sugi H
Cardiovascular research60(3)580-8(2003 Dec)

Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations.
Andersen PS, Havndrup O, Bundgaard H, Moolman-Smook JC, Larsen LA, Mogensen J, Brink PA, B?rglum AD, Corfield VA, Kjeldsen K, Vuust J, Christiansen M
Journal of medical genetics38(12)E43(2001 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Slowing of shortening velocity in type IIb fibers with hindlimb unloading involves a decrease in the relative amount of Myl3.
Title: The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.

The following Myl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa00444 NM_012606.2
Latest version!		 Rattus norvegicus myosin light chain 3 (Myl3), mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $139.30
$199.00
ORa00444 XM_006243917.3
Latest version!		 Rattus norvegicus myosin light chain 3 (Myl3), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 5-7 $139.30
$199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa00444
Clone ID Related Accession (Same CDS sequence) NM_012606.2 , XM_006243917.3
Accession Version NM_012606.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 603bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-24
Organism Rattus norvegicus(Norway rat)
Product myosin light chain 3
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081832.1. On Jan 26, 2008 this sequence version replaced NM_012606.1. ##Evidence-Data-START## Transcript exon combination :: BC081832.1, FQ216255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_036738.1
CDS53..655
Translation

Target ORF information:

RefSeq Version NM_012606.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus myosin light chain 3 (Myl3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_012606.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa00444
Clone ID Related Accession (Same CDS sequence) NM_012606.2 , XM_006243917.3
Accession Version XM_006243917.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 603bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product myosin light chain 3 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243917.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006243979.3
CDS76..678
Translation

Target ORF information:

RefSeq Version XM_006243917.3
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus myosin light chain 3 (Myl3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006243917.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.
American journal of physiology. Cell physiology293(2)C723-8(2007 Aug)
Zhong S,Thompson LV


book

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Circulation113(23)2697-705(2006 Jun)
Morita H,Larson MG,Barr SC,Vasan RS,O'Donnell CJ,Hirschhorn JN,Levy D,Corey D,Seidman CE,Seidman JG,Benjamin EJ


book

Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(7)865-73(2006 May)
Haase H,Dobbernack G,T?nnemann G,Karczewski P,Cardoso C,Petzhold D,Schlegel WP,Lutter S,Pierschalek P,Behlke J,Morano I


book

Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Cardiovascular research60(3)580-8(2003 Dec)
Yamashita H,Sugiura S,Fujita H,Yasuda Si,Nagai R,Saeki Y,Sunagawa K,Sugi H


book

Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations.
Journal of medical genetics38(12)E43(2001 Dec)
Andersen PS,Havndrup O,Bundgaard H,Moolman-Smook JC,Larsen LA,Mogensen J,Brink PA,B?rglum AD,Corfield VA,Kjeldsen K,Vuust J,Christiansen M