Myl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Myl3
Entrez Gene ID	24585
Full Name	myosin light chain 3
Synonyms	MLClV,Mylc1v,rVMLC1
General protein information	Preferred Names myosin light chain 3 Names myosin light chain 3 MLC1SB Myosin light chain 3, alkali, cardiac ventricles myosin alkali light chain 1, ventricular myosin light chain 1, slow-twitch muscle B/ventricular isoform myosin, light chain 3, alkali myosin, light chain 3, alkali; ventricular, skeletal, slow myosin, light polypeptide 3 ventricular myosin light chain 1 ventricular, skeletal, slow ventricular/slow twitch myosin alkali light chain
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	predominant myosin light chain in cardiac tissue [RGD, Feb 2006].

mRNA and Protein(s)

mRNA Protein Name

NM_012606.2 NP_036738.1 myosin light chain 3

XM_006243917.3 XP_006243979.3 myosin light chain 3 isoform X1
Pathways from BioSystems

mRNA	Protein	Name
NM_012606.2	NP_036738.1	myosin light chain 3
XM_006243917.3	XP_006243979.3	myosin light chain 3 isoform X1

Homologies

Mus musculus (house mouse)	Myl3	NP_034989.1
Homo sapiens (human)	MYL3	NP_000249.1
	MYL3	XP_001113910.1
Gallus gallus (chicken)	MYL3	NP_990490.1
Pan troglodytes (chimpanzee)	LOC460327	XP_003309811.2
Bos taurus (cattle)	MYL3	NP_001069969.2
Danio rerio (zebrafish)	zgc:66286	NP_956810.1
Xenopus tropicalis (tropical clawed frog)	myl3	NP_989012.1
Canis lupus familiaris (dog)	MYL3	XP_005632679.1
Rattus norvegicus (Norway rat)	Myl3	NP_036738.1

Gene Ontology
Bibliography

Related articles in PubMed

The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.
Zhong S, Thompson LV
American journal of physiology. Cell physiology293(2)C723-8(2007 Aug)

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Morita H, Larson MG, Barr SC, Vasan RS, O'Donnell CJ, Hirschhorn JN, Levy D, Corey D, Seidman CE, Seidman JG, Benjamin EJ
Circulation113(23)2697-705(2006 Jun)

Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats.
Haase H, Dobbernack G, T?nnemann G, Karczewski P, Cardoso C, Petzhold D, Schlegel WP, Lutter S, Pierschalek P, Behlke J, Morano I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(7)865-73(2006 May)

Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Yamashita H, Sugiura S, Fujita H, Yasuda Si, Nagai R, Saeki Y, Sunagawa K, Sugi H
Cardiovascular research60(3)580-8(2003 Dec)

Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations.
Andersen PS, Havndrup O, Bundgaard H, Moolman-Smook JC, Larsen LA, Mogensen J, Brink PA, B?rglum AD, Corfield VA, Kjeldsen K, Vuust J, Christiansen M
Journal of medical genetics38(12)E43(2001 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Slowing of shortening velocity in type IIb fibers with hindlimb unloading involves a decrease in the relative amount of Myl3.
Title: The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.

The following Myl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00444	NM_012606.2 Latest version!	Rattus norvegicus myosin light chain 3 (Myl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa00444	XM_006243917.3 Latest version!	Rattus norvegicus myosin light chain 3 (Myl3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Myl3 ( NM_012606.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036738.1 Rattus norvegicus myosin light chain 3 (Myl3), mRNA.

Price & Availability↑

CloneID	ORa00444
Clone ID Related Accession (Same CDS sequence)	NM_012606.2 , XM_006243917.3
Accession Version	NM_012606.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	myosin light chain 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081832.1. On Jan 26, 2008 this sequence version replaced NM_012606.1. ##Evidence-Data-START## Transcript exon combination :: BC081832.1, FQ216255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036738.1
CDS	53..655
Translation	MAPKKPEPKKDDAKTAAPKAAPAPAAAPAAAPEPERPKEAEFDASKIKIEFTPEQIEEFKEAFQLFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEELNSKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMAS

Target ORF information:

RefSeq Version	NM_012606.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myosin light chain 3 (Myl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012606.2

ORF Insert Sequence:

ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Myl3 ( XM_006243917.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243979.3 Rattus norvegicus myosin light chain 3 (Myl3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00444
Clone ID Related Accession (Same CDS sequence)	NM_012606.2 , XM_006243917.3
Accession Version	XM_006243917.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	myosin light chain 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243917.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243979.3
CDS	76..678
Translation	MAPKKPEPKKDDAKTAAPKAAPAPAAAPAAAPEPERPKEAEFDASKIKIEFTPEQIEEFKEAFQLFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEELNSKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMAS

Target ORF information:

RefSeq Version	XM_006243917.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myosin light chain 3 (Myl3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243917.3

ORF Insert Sequence:

ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GACGATGCCA AAACCGCTGC CCCCAAAGCA 
GCTCCGGCCC CTGCGGCTGC ACCTGCGGCT GCACCTGAGC CCGAACGCCC TAAGGAAGCA 
GAGTTTGATG CCTCCAAGAT TAAGATTGAG TTCACGCCTG AACAGATTGA AGAGTTCAAG 
GAGGCCTTCC AACTGTTTGA CCGCACACCT AAGGGCGAGA TGAAGATCAC GTACGGGCAG 
TGTGGGGATG TCCTGCGGGC TCTGGGACAG AATCCTACCC AGGCAGAGGT GCTCCGCGTC 
TTGGGGAAGC CCAAACAGGA AGAGCTCAAC TCCAAGATGA TGGATTTTGA AACATTCCTG 
CCCATGCTGC AGCACATCTC CAAGAACAAA GACACGGGCA CATATGAGGA CTTCGTGGAG 
GGGCTGCGGG TCTTCGACAA GGAGGGCAAC GGAACTGTTA TGGGTGCAGA GCTCCGTCAT 
GTGCTGGCCA CGCTGGGTGA GAGGCTGACA GAAGACGAGG TAGAGAAACT GATGGCTGGT 
CAAGAAGACT CCAATGGCTG CATCAACTAT GAAGCATTTG TGAAGCACAT CATGGCCAGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.
American journal of physiology. Cell physiology293(2)C723-8(2007 Aug)
Zhong S,Thompson LV

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Circulation113(23)2697-705(2006 Jun)
Morita H,Larson MG,Barr SC,Vasan RS,O'Donnell CJ,Hirschhorn JN,Levy D,Corey D,Seidman CE,Seidman JG,Benjamin EJ

Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(7)865-73(2006 May)
Haase H,Dobbernack G,T?nnemann G,Karczewski P,Cardoso C,Petzhold D,Schlegel WP,Lutter S,Pierschalek P,Behlke J,Morano I

Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Cardiovascular research60(3)580-8(2003 Dec)
Yamashita H,Sugiura S,Fujita H,Yasuda Si,Nagai R,Saeki Y,Sunagawa K,Sugi H

Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations.
Journal of medical genetics38(12)E43(2001 Dec)
Andersen PS,Havndrup O,Bundgaard H,Moolman-Smook JC,Larsen LA,Mogensen J,Brink PA,B?rglum AD,Corfield VA,Kjeldsen K,Vuust J,Christiansen M

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Myl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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