Ptpn1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Ptpn1 |
| Entrez Gene ID | 24697 |
| Full Name | protein tyrosine phosphatase, non-receptor type 1 |
| Synonyms | Ptp |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | protein-tyrosine-phosphatase which has only phosphotyrosine phosphatase activity [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_017591473.1 | XP_017446962.1 | tyrosine-protein phosphatase non-receptor type 1 isoform X1 |
| NM_012637.2 | NP_036769.1 | tyrosine-protein phosphatase non-receptor type 1 |
| Rattus norvegicus (Norway rat) | Ptpn1 | NP_036769.1 |
| Danio rerio (zebrafish) | ptpn1 | NP_570999.1 |
| Canis lupus familiaris (dog) | PTPN1 | XP_534455.3 |
| PTPN1 | XP_001096053.2 | |
| Bos taurus (cattle) | PTPN1 | NP_001093796.1 |
| Homo sapiens (human) | PTPN1 | NP_002818.1 |
| Pan troglodytes (chimpanzee) | PTPN1 | XP_525354.2 |
| Mus musculus (house mouse) | Ptpn1 | NP_035331.3 |
| Gallus gallus (chicken) | PTPN1 | NP_990206.1 |
| Xenopus tropicalis (tropical clawed frog) | ptpn1 | NP_001017121.2 |
Related articles in PubMed
Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior.
Mendes NF, Castro G, Guadagnini D, Tobar N, Cognuck SQ, Elias LL, Boer PA, Prada PO
Metabolism: clinical and experimental701-11(2017 May)
ZMPSTE24 defends against influenza and other pathogenic viruses.
Fu B, Wang L, Li S, Dorf ME
The Journal of experimental medicine214(4)919-929(2017 Apr)
Early life stress experience may blunt hypothalamic leptin signalling.
Lee JH, Yoo SB, Kim JY, Lee JY, Kim BT, Park K, Jahng JW
Journal of biosciences42(1)131-138(2017 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
deleterious role that the amygdalar PTP1B has on energy homeostasis in obesity states
Title: Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior.
The results suggest that neonatal MS experience may blunt the anorectic efficacy of leptin later in life, possibly in relation with increased expressions of PTP1B and/or pSTAT3 in the hypothalamus
Title: Early life stress experience may blunt hypothalamic leptin signalling.
These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis.
Title: Pancreatic Protein Tyrosine Phosphatase 1B Deficiency Exacerbates Acute Pancreatitis in Mice.
overexpression of PTP1B can inhibit glucose-stimulated insulin secretion in INS-1 cells through negatively regulating insulin signaling.
Title: Overexpression of protein tyrosine phosphatase 1B impairs glucose-stimulated insulin secretion in INS-1 cells.
After retinal detachment, weak immunolabeling of PTP1B was seen in the retinal pigment epithelial cells.
Title: Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells.
The following Ptpn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptpn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa12913 | |
| Clone ID Related Accession (Same CDS sequence) | NM_012637.2 | |
| Accession Version | NM_012637.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | tyrosine-protein phosphatase non-receptor type 1 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081829.1. On Jun 10, 2007 this sequence version replaced NM_012637.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGAAATGG AGAAGGAATT CGAGCAGATC GATAAGGCTG GGAACTGGGC GGCTATTTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_036769.1 |
| CDS | 78..1376 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_012637.2 |
ORF Insert Sequence:
1 | ATGGAAATGG AGAAGGAATT CGAGCAGATC GATAAGGCTG GGAACTGGGC GGCTATTTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa26718 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017591473.1 | |
| Accession Version | XM_017591473.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | tyrosine-protein phosphatase non-receptor type 1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAAATGG AGAAGGAATT CGAGCAGATC GATAAGGCTG GGAACTGGGC GGCTATTTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017446962.1 |
| CDS | 148..1440 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017591473.1 |
ORF Insert Sequence:
1 | ATGGAAATGG AGAAGGAATT CGAGCAGATC GATAAGGCTG GGAACTGGGC GGCTATTTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior. |
|
ZMPSTE24 defends against influenza and other pathogenic viruses. |
|
Early life stress experience may blunt hypothalamic leptin signalling. |