Cycs cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Cycs
Entrez Gene ID	25309
Full Name	cytochrome c, somatic
Synonyms	CYCSA
General protein information	Preferred Names cytochrome c, somatic Names cytochrome c, somatic Cytochrome C, expressed in somatic tissues
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24
Summary	a component of the electron transport chain in mitochondria, may function in apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA Protein Name

NM_012839.2 NP_036971.1 cytochrome c, somatic
Pathways from BioSystems

mRNA	Protein	Name
NM_012839.2	NP_036971.1	cytochrome c, somatic

Homologies

Bos taurus (cattle)	CYCS	NP_001039526.1
Rattus norvegicus (Norway rat)	Cycs	NP_036971.1
Drosophila melanogaster (fruit fly)	Cyt-c-p	NP_477176.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009537	XP_310154.1
Eremothecium gossypii	AGOS_AFR360W	NP_985907.1
Rattus norvegicus (Norway rat)	LOC100363502	XP_003751847.1
Gallus gallus (chicken)	CYCS	NP_001072946.1
Homo sapiens (human)	CYCS	NP_061820.1
Caenorhabditis elegans (roundworm)	cyc-2.2	NP_506156.1
Kluyveromyces lactis	KLLA0F16929g	XP_455841.1
Xenopus tropicalis (tropical clawed frog)	cycs	NP_988895.1
	LOC694977	XP_001085135.1
Canis lupus familiaris (dog)	CYCS	NP_001183974.1
Mus musculus (house mouse)	Cycs	NP_031834.1
Caenorhabditis elegans (roundworm)	cyc-2.1	NP_500629.1
Saccharomyces cerevisiae (baker's yeast)	CYC1	NP_012582.1

Gene Ontology
Bibliography

Related articles in PubMed

[Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload].
Ye L, Yang S
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(8)1031-5(2015 Aug)

Poly (ADP?ribose) polymerase? and cytochrome?c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure.
Gao G, Yu Z, Yan J, Li J, Shen S, Jia B, Guan K, Gao X, Kan Q
Molecular medicine reports11(6)4211-9(2015 Jun)

Extracellular cytochrome c as a biomarker for monitoring therapeutic efficacy and prognosis of non-small cell lung cancer patients.
Javid J, Mir R, Julka PK, Ray PC, Saxena A
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(6)4253-60(2015 Jun)

Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
Pu H, Wang X, Su L, Ma C, Zhang Y, Zhang L, Chen X, Li X, Wang H, Liu X, Zhang J
Medical science monitor basic research2153-62(2015 Apr)

[Cytochrome C content and mitochondrial activity in rat's cardiac and skeletal muscle cells in the course of 3-day gravitational unloading].
Ogneva IV, Birjukov NS, Veselova OM, Larina IM
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine48(6)23-9(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that sirtuin 3 could inhibit cell apoptosis by reducing cytochrome C (CytC) release and inhibiting caspase-3 activation in cardiomyocyte models with calcium overload.
Title: [Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload].

results suggested that hepatocyte injury and liver dysfunction may be caused by inducing apoptosis via the PARP and Cyt C pathways.
Title: Poly (ADP?ribose) polymerase? and cytochrome?c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure.

Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
Title: Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.

The findings provide insights into the function of CPR and CPR-cyt c interaction on a structural basis.
Title: Kinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c.

Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats.
Title: Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats.

The following Cycs gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cycs cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12858	NM_012839.2 Latest version!	Rattus norvegicus cytochrome c, somatic (Cycs), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cycs ( NM_012839.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036971.1 Rattus norvegicus cytochrome c, somatic (Cycs), mRNA.

Price & Availability↑

CloneID	ORa12858
Clone ID Related Accession (Same CDS sequence)	NM_012839.2
Accession Version	NM_012839.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome c, somatic
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081849.1. On Oct 17, 2004 this sequence version replaced NM_012839.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081849.1, FQ219963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMN01906347 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAAA AGTGTGCCCA GTGCCACACT 
GTGGAAAAAG GAGGCAAGCA TAAGACTGGA CCAAACCTCC ATGGTCTGTT TGGGCGGAAG 
ACAGGCCAGG CTGCTGGATT CTCTTACACA GATGCCAACA AGAACAAAGG TATCACCTGG 
GGAGAGGATA CCCTGATGGA GTATTTGGAA AATCCCAAAA AGTACATCCC TGGAACAAAA 
ATGATCTTCG CTGGAATTAA GAAGAAGGGA GAAAGGGCAG ACCTAATAGC TTATCTTAAA 
AAGGCTACTA ATGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036971.1
CDS	76..393
Translation	MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE

Target ORF information:

RefSeq Version	NM_012839.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome c, somatic (Cycs), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012839.2

ORF Insert Sequence:

ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAAA AGTGTGCCCA GTGCCACACT 
GTGGAAAAAG GAGGCAAGCA TAAGACTGGA CCAAACCTCC ATGGTCTGTT TGGGCGGAAG 
ACAGGCCAGG CTGCTGGATT CTCTTACACA GATGCCAACA AGAACAAAGG TATCACCTGG 
GGAGAGGATA CCCTGATGGA GTATTTGGAA AATCCCAAAA AGTACATCCC TGGAACAAAA 
ATGATCTTCG CTGGAATTAA GAAGAAGGGA GAAAGGGCAG ACCTAATAGC TTATCTTAAA 
AAGGCTACTA ATGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(8)1031-5(2015 Aug)
Ye L,Yang S

Poly (ADP?ribose) polymerase? and cytochrome?c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure.
Molecular medicine reports11(6)4211-9(2015 Jun)
Gao G,Yu Z,Yan J,Li J,Shen S,Jia B,Guan K,Gao X,Kan Q

Extracellular cytochrome c as a biomarker for monitoring therapeutic efficacy and prognosis of non-small cell lung cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(6)4253-60(2015 Jun)
Javid J,Mir R,Julka PK,Ray PC,Saxena A

Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
Medical science monitor basic research2153-62(2015 Apr)
Pu H,Wang X,Su L,Ma C,Zhang Y,Zhang L,Chen X,Li X,Wang H,Liu X,Zhang J

[Cytochrome C content and mitochondrial activity in rat's cardiac and skeletal muscle cells in the course of 3-day gravitational unloading].
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine48(6)23-9(2014)
Ogneva IV,Birjukov NS,Veselova OM,Larina IM

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Cycs cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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