Cycs cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Cycs |
| Entrez Gene ID | 25309 |
| Full Name | cytochrome c, somatic |
| Synonyms | CYCSA |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | a component of the electron transport chain in mitochondria, may function in apoptosis [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_012839.2 | NP_036971.1 | cytochrome c, somatic |
| Bos taurus (cattle) | CYCS | NP_001039526.1 |
| Rattus norvegicus (Norway rat) | Cycs | NP_036971.1 |
| Drosophila melanogaster (fruit fly) | Cyt-c-p | NP_477176.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009537 | XP_310154.1 |
| Eremothecium gossypii | AGOS_AFR360W | NP_985907.1 |
| Rattus norvegicus (Norway rat) | LOC100363502 | XP_003751847.1 |
| Gallus gallus (chicken) | CYCS | NP_001072946.1 |
| Homo sapiens (human) | CYCS | NP_061820.1 |
| Caenorhabditis elegans (roundworm) | cyc-2.2 | NP_506156.1 |
| Kluyveromyces lactis | KLLA0F16929g | XP_455841.1 |
| Xenopus tropicalis (tropical clawed frog) | cycs | NP_988895.1 |
| LOC694977 | XP_001085135.1 | |
| Canis lupus familiaris (dog) | CYCS | NP_001183974.1 |
| Mus musculus (house mouse) | Cycs | NP_031834.1 |
| Caenorhabditis elegans (roundworm) | cyc-2.1 | NP_500629.1 |
| Saccharomyces cerevisiae (baker's yeast) | CYC1 | NP_012582.1 |
Related articles in PubMed
[Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload].
Ye L, Yang S
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(8)1031-5(2015 Aug)
Poly (ADP?ribose) polymerase? and cytochrome?c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure.
Gao G, Yu Z, Yan J, Li J, Shen S, Jia B, Guan K, Gao X, Kan Q
Molecular medicine reports11(6)4211-9(2015 Jun)
Extracellular cytochrome c as a biomarker for monitoring therapeutic efficacy and prognosis of non-small cell lung cancer patients.
Javid J, Mir R, Julka PK, Ray PC, Saxena A
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(6)4253-60(2015 Jun)
Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
Pu H, Wang X, Su L, Ma C, Zhang Y, Zhang L, Chen X, Li X, Wang H, Liu X, Zhang J
Medical science monitor basic research2153-62(2015 Apr)
[Cytochrome C content and mitochondrial activity in rat's cardiac and skeletal muscle cells in the course of 3-day gravitational unloading].
Ogneva IV, Birjukov NS, Veselova OM, Larina IM
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine48(6)23-9(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that sirtuin 3 could inhibit cell apoptosis by reducing cytochrome C (CytC) release and inhibiting caspase-3 activation in cardiomyocyte models with calcium overload.
Title: [Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload].
results suggested that hepatocyte injury and liver dysfunction may be caused by inducing apoptosis via the PARP and Cyt C pathways.
Title: Poly (ADP?ribose) polymerase? and cytochrome?c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure.
Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
Title: Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis.
The findings provide insights into the function of CPR and CPR-cyt c interaction on a structural basis.
Title: Kinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c.
Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats.
Title: Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats.
The following Cycs gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cycs cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa12858 | |
| Clone ID Related Accession (Same CDS sequence) | NM_012839.2 | |
| Accession Version | NM_012839.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | cytochrome c, somatic | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081849.1. On Oct 17, 2004 this sequence version replaced NM_012839.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081849.1, FQ219963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMN01906347 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## | |
1 | ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAAA AGTGTGCCCA GTGCCACACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_036971.1 |
| CDS | 76..393 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_012839.2 |
ORF Insert Sequence:
1 | ATGGGTGATG TTGAAAAAGG CAAGAAGATT TTTGTTCAAA AGTGTGCCCA GTGCCACACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
[Sirtuin 3 inhibits cardiomyocyte apoptosis by reducing cytochrome C release in myocardiac H9c2 cells with calcium overload]. |
|
Poly (ADP?ribose) polymerase? and cytochrome?c?mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia?induced hepatic failure. |
|
Extracellular cytochrome c as a biomarker for monitoring therapeutic efficacy and prognosis of non-small cell lung cancer patients. |
|
Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis. |
|
[Cytochrome C content and mitochondrial activity in rat's cardiac and skeletal muscle cells in the course of 3-day gravitational unloading]. |