Ppp1r14d cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1r14d
Entrez Gene ID	259226
Full Name	protein phosphatase 1, regulatory (inhibitor) subunit 14D
Synonyms	Gbpi
General protein information	Preferred Names protein phosphatase 1, regulatory (inhibitor) subunit 14D Names protein phosphatase 1 regulatory subunit 14D GBPI-1 gastrointestinal and brain-specific PP1-inhibitory protein 1 gastrointestinal- and brain-specific PKC-activated PP1 inhibitor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35

mRNA and Protein(s)

mRNA	Protein	Name
NM_172011.1	NP_742008.1	protein phosphatase 1 regulatory subunit 14D

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PPP1R14D	NP_001092639.1
Gallus gallus (chicken)	PPP1R14D	XP_421129.3
Pan troglodytes (chimpanzee)	PPP1R14D	XP_001146790.1
Canis lupus familiaris (dog)	PPP1R14D	XP_003640090.1
Rattus norvegicus (Norway rat)	Ppp1r14d	NP_742008.1
Homo sapiens (human)	PPP1R14D	NP_060196.1
Mus musculus (house mouse)	Ppp1r14d	NP_082380.1
Xenopus tropicalis (tropical clawed frog)	ppp1r14d	XP_004917491.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of the brain proteome of rats with diabetes mellitus through two-dimensional electrophoresis and mass spectrometry.
Karthik D, Ravikumar S
Brain research1371171-9(2011 Jan)

Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity.
Kawamoto EM, Munhoz CD, Lepsch LB, de S? Lima L, Glezer I, Markus RP, de Silva CL, Camarini R, Marcourakis T, Scavone C
Neurobiology of aging29(11)1712-20(2008 Nov)

GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.
Liu QR, Zhang PW, Lin Z, Li QF, Woods AS, Troncoso J, Uhl GR
The Biochemical journal377(Pt 1)171-81(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Brain PPP1R14D is upregulated in alloxan diabetes. It inhibits the function of PP1, switches-on glycogen breakdown and switches-off glycogen synthesis due to lack of insulin.
Title: Characterization of the brain proteome of rats with diabetes mellitus through two-dimensional electrophoresis and mass spectrometry.

PP-1 activity due to a decrease in cyclic GMP-PKG modulation plays a role for the age-related reduction of alpha(2/3)-Na,K-ATPase activity in rat cerebellum.
Title: Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity.

A gastrointestinal- and brain-specific PP1 inhibitory protein (GBPI-1)is activated by PKC phosphorylation. A longer GBPI-2 splice variant mRNA is found in testis.
Title: GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.

The following Ppp1r14d gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r14d cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02858	NM_172011.1 Latest version!	Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 14D (Ppp1r14d), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1r14d ( NM_172011.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_742008.1 Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 14D (Ppp1r14d), mRNA.

Price & Availability↑

CloneID	ORa02858
Clone ID Related Accession (Same CDS sequence)	NM_172011.1
Accession Version	NM_172011.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-14
Organism	Rattus norvegicus(Norway rat)
Product	protein phosphatase 1 regulatory subunit 14D
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY122322.1. ##Evidence-Data-START## Transcript exon combination :: AY122322.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMN02642779 [ECO:0000348] ##Evidence-Data-END##

ATGCTGTCGT CAAGCGCTGC TTCCTGTACA TCTCCCAACC CTGACACAGA CAACCCAGAC 
AAGAAGGTCC GCTGGTCTTC TGAGAAGAGA AGGAGGGCAT CATCCACAGA CTCAGAGTCA 
AAGACTCACT TGGACATTTC TAAGTTGCCC AGGTCCCGGA GACCCAGCCG GCTGACGGTG 
AAGTATGACC GGGGTCATCT GCAGCGCTGG CTGGAGATGG AGCAATGGGT AGATGCTCAG 
GTTCAGGAAC TCTTCCAGGG TCAAGCAGAT ACTTCTGAGC CCGAGATCGA TCTGGAAGCT 
CTAATGGAAT TGTCCACAGA CGAGCAAAGG ACTCAGCTGG AGGCCATTCT CCAAGACTGC 
CCAGGCAACA GAGAGCCTTT TATCTCTGAG CTACTCAGTC AACTCAAGAG ACTTCGGAGA 
CTCAGCAGGC CTTCGAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742008.1
CDS	43..483
Translation	MLSSSAASCTSPNPDTDNPDKKVRWSSEKRRRASSTDSESKTHLDISKLPRSRRPSRLTVKYDRGHLQRWLEMEQWVDAQVQELFQGQADTSEPEIDLEALMELSTDEQRTQLEAILQDCPGNREPFISELLSQLKRLRRLSRPSK

Target ORF information:

RefSeq Version	NM_172011.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 14D (Ppp1r14d), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172011.1

ORF Insert Sequence:

ATGCTGTCGT CAAGCGCTGC TTCCTGTACA TCTCCCAACC CTGACACAGA CAACCCAGAC 
AAGAAGGTCC GCTGGTCTTC TGAGAAGAGA AGGAGGGCAT CATCCACAGA CTCAGAGTCA 
AAGACTCACT TGGACATTTC TAAGTTGCCC AGGTCCCGGA GACCCAGCCG GCTGACGGTG 
AAGTATGACC GGGGTCATCT GCAGCGCTGG CTGGAGATGG AGCAATGGGT AGATGCTCAG 
GTTCAGGAAC TCTTCCAGGG TCAAGCAGAT ACTTCTGAGC CCGAGATCGA TCTGGAAGCT 
CTAATGGAAT TGTCCACAGA CGAGCAAAGG ACTCAGCTGG AGGCCATTCT CCAAGACTGC 
CCAGGCAACA GAGAGCCTTT TATCTCTGAG CTACTCAGTC AACTCAAGAG ACTTCGGAGA 
CTCAGCAGGC CTTCGAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of the brain proteome of rats with diabetes mellitus through two-dimensional electrophoresis and mass spectrometry.
Brain research1371171-9(2011 Jan)
Karthik D,Ravikumar S

Age-related changes in cerebellar phosphatase-1 reduce Na,K-ATPase activity.
Neurobiology of aging29(11)1712-20(2008 Nov)
Kawamoto EM,Munhoz CD,Lepsch LB,de S? Lima L,Glezer I,Markus RP,de Silva CL,Camarini R,Marcourakis T,Scavone C

GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.
The Biochemical journal377(Pt 1)171-81(2004 Jan)
Liu QR,Zhang PW,Lin Z,Li QF,Woods AS,Troncoso J,Uhl GR

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Ppp1r14d cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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