Skp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Skp1
Entrez Gene ID	287280
Full Name	S-phase kinase-associated protein 1
Synonyms	Skp1a
General protein information	Preferred Names S-phase kinase-associated protein 1 Names S-phase kinase-associated protein 1 RNA polymerase II elongation factor-like protein OCP2 S-phase kinase-associated protein 1A cyclin A/CDK2-associated p19 cyclin-A/CDK2-associated protein p19 organ of Corti protein 2 p19A p19skp1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22

mRNA and Protein(s)

mRNA Protein Name

NM_001007608.2 NP_001007609.1 S-phase kinase-associated protein 1
Pathways from BioSystems

mRNA	Protein	Name
NM_001007608.2	NP_001007609.1	S-phase kinase-associated protein 1

Homologies

Canis lupus familiaris (dog)	SKP1	NP_001239337.1
Drosophila melanogaster (fruit fly)	skpA	NP_726695.1
Caenorhabditis elegans (roundworm)	skr-1	NP_492513.1
Kluyveromyces lactis	KLLA0E16941g	XP_454713.1
Eremothecium gossypii	AGOS_ADR295C	NP_984392.1
Schizosaccharomyces pombe (fission yeast)	skp1	NP_595455.1
Xenopus tropicalis (tropical clawed frog)	skp1	NP_001016519.1
Gallus gallus (chicken)	SKP1	NP_001006153.1
Saccharomyces cerevisiae (baker's yeast)	SKP1	NP_010615.3
Homo sapiens (human)	SKP1	NP_733779.1
Pan troglodytes (chimpanzee)	SKP1	XP_003950673.1
Bos taurus (cattle)	SKP1	NP_001029953.1
Danio rerio (zebrafish)	skp1	NP_957037.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008719	XP_314827.2
Caenorhabditis elegans (roundworm)	skr-2	NP_492512.1
Magnaporthe oryzae (rice blast fungus)	MGG_04978	XP_003712477.1
Neurospora crassa	NCU08991	XP_959019.1
	LOC703550	XP_001094634.1
Mus musculus (house mouse)	Skp1a	NP_035673.3
Rattus norvegicus (Norway rat)	Skp1	NP_001007609.1
Oryza sativa (rice)	Os11g0456300	NP_001176525.1

Gene Ontology
Bibliography

Related articles in PubMed

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H
The EMBO journal36(3)260-273(2017 Feb)

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
Chu WK, Payne MJ, Beli P, Hanada K, Choudhary C, Hickson ID
Nature communications65931(2015 Jan)

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.
Hayes JD, Dinkova-Kostova AT
Trends in biochemical sciences39(4)199-218(2014 Apr)

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
Hirano A, Yumimoto K, Tsunematsu R, Matsumoto M, Oyama M, Kozuka-Hata H, Nakagawa T, Lanjakornsiripan D, Nakayama KI, Fukada Y
Cell152(5)1106-18(2013 Feb)

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Fern?ndez-S?iz V, Targosz BS, Lemeer S, Eichner R, Langer C, Bullinger L, Reiter C, Slotta-Huspenina J, Schroeder S, Knorn AM, Kurutz J, Peschel C, Pagano M, Kuster B, Bassermann F
Nature cell biology15(1)72-81(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study indicated that cyclin A, cyclin D, Cdk2, Cdk4, and p21 are involved in microglial proliferation in the transected facial nucleus.
Title: Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus.

The following Skp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Skp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11110	NM_001007608.2 Latest version!	Rattus norvegicus S-phase kinase-associated protein 1 (Skp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Skp1 ( NM_001007608.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007609.1 Rattus norvegicus S-phase kinase-associated protein 1 (Skp1), mRNA.

Price & Availability↑

CloneID	ORa11110
Clone ID Related Accession (Same CDS sequence)	NM_001007608.2
Accession Version	NM_001007608.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Rattus norvegicus(Norway rat)
Product	S-phase kinase-associated protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058152.1. On Aug 30, 2012 this sequence version replaced NM_001007608.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058152.1, CF111133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTACGA TAAAGTTGCA GAGTTCTGAT GGAGAGATAT TTGAAGTTGA TGTAGAAATT 
GCCAAACAAT CTGTGACCAT TAAGACCATG CTGGAAGATT TGGGAATGGA TGATGAGGGA 
GATGATGATC CTGTTCCTTT ACCAAATGTT AATGCAGCAA TTCTAAAAAA GGTCATTCAG 
TGGTGCACCC ACCACAAGGA TGACCCTCCT CCTCCTGAGG ATGATGAGAA CAAAGAGAAG 
CGGACAGATG ATATTCCTGT TTGGGACCAA GAATTCCTGA AAGTTGACCA AGGAACACTT 
TTTGAACTTA TTCTGGCTGC AAACTACTTA GACATCAAAG GTTTGCTTGA TGTCACCTGC 
AAGACTGTGG CTAATATGAT TAAGGGGAAA ACGCCTGAGG AGATTCGTAA AACCTTCAAT 
ATCAAAAATG ACTTTACTGA AGAGGAGGAG GCCCAGGTAC GCAAAGAGAA CCAGTGGTGT 
GAAGAGAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007609.1
CDS	84..575
Translation	MPTIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK

Target ORF information:

RefSeq Version	NM_001007608.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus S-phase kinase-associated protein 1 (Skp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007608.2

ORF Insert Sequence:

ATGCCTACGA TAAAGTTGCA GAGTTCTGAT GGAGAGATAT TTGAAGTTGA TGTAGAAATT 
GCCAAACAAT CTGTGACCAT TAAGACCATG CTGGAAGATT TGGGAATGGA TGATGAGGGA 
GATGATGATC CTGTTCCTTT ACCAAATGTT AATGCAGCAA TTCTAAAAAA GGTCATTCAG 
TGGTGCACCC ACCACAAGGA TGACCCTCCT CCTCCTGAGG ATGATGAGAA CAAAGAGAAG 
CGGACAGATG ATATTCCTGT TTGGGACCAA GAATTCCTGA AAGTTGACCA AGGAACACTT 
TTTGAACTTA TTCTGGCTGC AAACTACTTA GACATCAAAG GTTTGCTTGA TGTCACCTGC 
AAGACTGTGG CTAATATGAT TAAGGGGAAA ACGCCTGAGG AGATTCGTAA AACCTTCAAT 
ATCAAAAATG ACTTTACTGA AGAGGAGGAG GCCCAGGTAC GCAAAGAGAA CCAGTGGTGT 
GAAGAGAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
The EMBO journal36(3)260-273(2017 Feb)
Reiterer V,Figueras-Puig C,Le Guerroue F,Confalonieri S,Vecchi M,Jalapothu D,Kanse SM,Deshaies RJ,Di Fiore PP,Behrends C,Farhan H

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
Nature communications65931(2015 Jan)
Chu WK,Payne MJ,Beli P,Hanada K,Choudhary C,Hickson ID

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.
Trends in biochemical sciences39(4)199-218(2014 Apr)
Hayes JD,Dinkova-Kostova AT

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
Cell152(5)1106-18(2013 Feb)
Hirano A,Yumimoto K,Tsunematsu R,Matsumoto M,Oyama M,Kozuka-Hata H,Nakagawa T,Lanjakornsiripan D,Nakayama KI,Fukada Y

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Nature cell biology15(1)72-81(2013 Jan)
Fern?ndez-S?iz V,Targosz BS,Lemeer S,Eichner R,Langer C,Bullinger L,Reiter C,Slotta-Huspenina J,Schroeder S,Knorn AM,Kurutz J,Peschel C,Pagano M,Kuster B,Bassermann F

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Skp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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