Smg6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Smg6
Entrez Gene ID	287522
Full Name	SMG6 nonsense mediated mRNA decay factor
Synonyms	LRRGT00040,RGD1309609
General protein information	Preferred Names SMG6 nonsense mediated mRNA decay factor Names telomerase-binding protein EST1A Smg-6 homolog, nonsense mediated mRNA decay factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105808.1	NP_001099278.1	telomerase-binding protein EST1A
XM_006246866.3	XP_006246928.1	telomerase-binding protein EST1A isoform X1
XM_008767960.2	XP_008766182.1	telomerase-binding protein EST1A isoform X2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SMG6	XP_548319.3
	LOC721291	XP_002800291.1
Gallus gallus (chicken)	LOC101750600	XP_004946606.1
Homo sapiens (human)	SMG6	NP_060045.4
Danio rerio (zebrafish)	LOC100334020	XP_005172798.1
Pan troglodytes (chimpanzee)	SMG6	XP_003315338.1
Bos taurus (cattle)	SMG6	NP_001192756.1
Rattus norvegicus (Norway rat)	Smg6	NP_001099278.1
Xenopus tropicalis (tropical clawed frog)	smg6	XP_002937186.2
Mus musculus (house mouse)	Smg6	NP_001002764.1

Gene Ontology
Bibliography

Related articles in PubMed

The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
Sealey DC, Kostic AD, LeBel C, Pryde F, Harrington L
BMC molecular biology1245(2011 Oct)

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.
Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN, Izaurralde E
Genes & development24(21)2440-50(2010 Nov)

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells.
Eberle AB, Lykke-Andersen S, M?hlemann O, Jensen TH
Nature structural & molecular biology16(1)49-55(2009 Jan)

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan.
Huntzinger E, Kashima I, Fauser M, Sauli?re J, Izaurralde E
RNA (New York, N.Y.)14(12)2609-17(2008 Dec)

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase.
Redon S, Reichenbach P, Lingner J
Nucleic acids research35(20)7011-22(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Smg6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Smg6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa44589	XM_008767960.2 Latest version!	Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa33422	XM_006246866.3 Latest version!	Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa11455	NM_001105808.1 Latest version!	Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$727.30 $1039.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Smg6 ( XM_008767960.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766182.1 Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa44589
Clone ID Related Accession (Same CDS sequence)	XM_008767960.2
Accession Version	XM_008767960.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	telomerase-binding protein EST1A isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767960.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTGGCT ACCCAGACAC CTGGAATCCT CCGCCCACAT CTTTGGATCT GCCCTTGCAG 
GTTGCTGTGG ATGTATGGTC AACACTTGCT GATTTCTGTA ACATACTGAC TGCAGTGAAT 
CAGTCTGAGG TGCCACTGTA CAAGGACCCA GATGATGACC TCACCCTGCT TATCCTGGAA 
GAGGATCGGC TTCTCTCTGG CTTTGTCCCC TTGCTGGCTG CCCCTCAGGA CCCCTGCTAC 
GTGGAGAAAA CCTCGGATAA GGTTATTGCA GCTGACTGCA AAAGGGTCAC AGTGCTGAAG 
TATTTTCTGG AAGCCCTTTG TGGACAAGAA GAGCCTCTGC TGGCATTCAA GGGTGGAAAA 
TATGTGTCAG TGGCACCCGT CCCAGACACC ATGGGAAAGG AAATGGGAAT CCAAGAGGGA 
AAACAACTGG AAGATGAGGA AGAAGATGTG GTGATTGAAG ACTTTGAGGA AGATTCAGAG 
GCTGAAGGTA GTGGGGGTGA GGATGACATC AGGGAACTTC GGGCCAAGAA GCTGGCTCTA 
GCAAGGAAAA TAGCTGAACA GCAGCGTCGC CAGGAAAAGA TCCAGGCTGT TTTGGAAGAC 
CAGAGTCAGA TGAGACAGAT GGAGCTGGAG ATCAGACCCT TGTTCCTCGT ACCAGATACC 
AACGGCTTCA TTGACCACCT GGCCAGTCTA GCTCGGCTGC TGGAGAGCAG GAAGTACATC 
CTGGTGGTGC CCCTCATCGT GATCAATGAG CTGGATGGCC TCGCCAAAGG GCAGGAGACA 
GACCACCGGG CTGGGGGCTA TGCCCGTGTG GTGCAAGAAA AGGCCCGAAA ATCCATCGAG 
TTCCTTGAAC GGAGATTTGA GAGTCGGGAC TCCTGCCTGC GGGCCTTGAC CAGCCGTGGC 
AATGAACTTG AATCTATCGC CTTCCGAAGT GAGGACATTA CTGGACAGCT GGGCAACAAC 
GATGACCTGA TCCTTTCCTG CTGCCTGCAC TACTGCAAAG ACAAAGCTAA GGACTACATG 
CCCACCAGCA AAGAGGAGCC CATCCGCTTG CTACGGGAAG TGGTGTTGCT GACGGATGAT 
CGGAACCTTC GTGTAAAGGC ACTAACAAGG AATGTGCCTG TGAGGGACAT CCCAGCCTTC 
CTTACGTGGG CCCAGGTGGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766182.1
CDS	1832..2995
Translation	MLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGIQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG

Target ORF information:

RefSeq Version	XM_008767960.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767960.2

ORF Insert Sequence:

ATGCTTGGCT ACCCAGACAC CTGGAATCCT CCGCCCACAT CTTTGGATCT GCCCTTGCAG 
GTTGCTGTGG ATGTATGGTC AACACTTGCT GATTTCTGTA ACATACTGAC TGCAGTGAAT 
CAGTCTGAGG TGCCACTGTA CAAGGACCCA GATGATGACC TCACCCTGCT TATCCTGGAA 
GAGGATCGGC TTCTCTCTGG CTTTGTCCCC TTGCTGGCTG CCCCTCAGGA CCCCTGCTAC 
GTGGAGAAAA CCTCGGATAA GGTTATTGCA GCTGACTGCA AAAGGGTCAC AGTGCTGAAG 
TATTTTCTGG AAGCCCTTTG TGGACAAGAA GAGCCTCTGC TGGCATTCAA GGGTGGAAAA 
TATGTGTCAG TGGCACCCGT CCCAGACACC ATGGGAAAGG AAATGGGAAT CCAAGAGGGA 
AAACAACTGG AAGATGAGGA AGAAGATGTG GTGATTGAAG ACTTTGAGGA AGATTCAGAG 
GCTGAAGGTA GTGGGGGTGA GGATGACATC AGGGAACTTC GGGCCAAGAA GCTGGCTCTA 
GCAAGGAAAA TAGCTGAACA GCAGCGTCGC CAGGAAAAGA TCCAGGCTGT TTTGGAAGAC 
CAGAGTCAGA TGAGACAGAT GGAGCTGGAG ATCAGACCCT TGTTCCTCGT ACCAGATACC 
AACGGCTTCA TTGACCACCT GGCCAGTCTA GCTCGGCTGC TGGAGAGCAG GAAGTACATC 
CTGGTGGTGC CCCTCATCGT GATCAATGAG CTGGATGGCC TCGCCAAAGG GCAGGAGACA 
GACCACCGGG CTGGGGGCTA TGCCCGTGTG GTGCAAGAAA AGGCCCGAAA ATCCATCGAG 
TTCCTTGAAC GGAGATTTGA GAGTCGGGAC TCCTGCCTGC GGGCCTTGAC CAGCCGTGGC 
AATGAACTTG AATCTATCGC CTTCCGAAGT GAGGACATTA CTGGACAGCT GGGCAACAAC 
GATGACCTGA TCCTTTCCTG CTGCCTGCAC TACTGCAAAG ACAAAGCTAA GGACTACATG 
CCCACCAGCA AAGAGGAGCC CATCCGCTTG CTACGGGAAG TGGTGTTGCT GACGGATGAT 
CGGAACCTTC GTGTAAAGGC ACTAACAAGG AATGTGCCTG TGAGGGACAT CCCAGCCTTC 
CTTACGTGGG CCCAGGTGGG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Smg6 ( XM_006246866.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246928.1 Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33422
Clone ID Related Accession (Same CDS sequence)	XM_006246866.3
Accession Version	XM_006246866.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	telomerase-binding protein EST1A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246866.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTTTTGC TCCCAGTGCG GCCACCGTCG TTTGGGGAGG GCAGGCAGGA GGGGGCGGGG 
AAAAGGGTGG GAGTGGGTGA GCGCGCGCCG CCCGTCCGTC GTGGTTTCCT GGCTGCGCGC 
GGCGGTGGTG GAGTCGCCGC AGCTGTAGCA GCCGCCGCGA AGATGGCGGA GGGGTTGGAG 
CGTGTGCGGA TCTCCGCGTC GGAACTGCGA GGGATCCTGG CCACTCTGGC TCCGCAGGCC 
GGGAGCAGAG AAAACATGAA GGAACTAAAG GAACCCAGGC AGCGCAAAGA TAACAGGCGC 
CCAGATTTGG AAATCTACAA GCCTGGGCTT TCTCGACTGA GAAACAGACC TAAAACCAAG 
GAGGCTTCTG GGAATGAGGA ATTCAAAGAT GAGATTGTGA ATGACAGAGA TGCTTCTGCT 
GTTGGGAATG ATACACAACT TATTAAAGTT TGCAAGGAAT TGGACAGCCA ACAGCAAAAT 
GGCCCTATAG ATGCAGAAAA TAGTCAGGCA CAGGAGACTT TCTCAAAGAC TGTTGGACTA 
GAGGACCGAA GTCTAAAAAT CATCAAGAGA ATCAAGAAAC CAGACCTGCA GATCTACCAG 
CCTGGAAGGC GGTTGCAGAC TGTTACCAAA GAGTCAGCGG GTAGGGCAGA TGAAGAAGAA 
ATCCTCAACC AAGTGGAGCA GTTGACGATG GAAGGGGATG AGTGTAGGGG AGAAGCTATA 
AAAGAAGAAG TTATCAACAA ACCGGATAAA ACCGAGATAG AAAAGAGCCA AAGTAATGAC 
CGTGTAAGAA CTGCCAAGGG AGAAAAGGGG AAAAAGATTG ATAAGGGGGA GGGGTCAAAA 
AAGGTGACTG ATGACTCTGT CCAAGGAAAG CCTGGCTCTG TAAAGAGGTA CTCACGATCA 
GACAAGAGAA GGAACCGCTA TCGCACTTGC AGTACCAGCT CAGCTGGTAG CAACAACAGT 
GCAGAGGGAG CTGGCCTGAC TGATAATGGA TGTCGCCGGC GGCGCCAGGA CCGGACCAAA 
GAGAGGCCAC GACTGAAGAA ACAGGTATCT ATGTCCTCAA CTGATTCCTT AGATGAGGAC 
AGAGTTACTG AGCCTGATGG ATTAGGGTCC AGGAGGAGCT CAGAAAGGAA GAAGCATTTA 
GACAGAAATT GGTCTGGCCG AGGTGAGGGT GAACAGAAAA GCAATGGTAA AGAAAACCGA 
GGCGCCCTTC GTGTCACTTT TGATGCAGAA GCCATGAGTA AAGACTCCCC TGTGGTAAGG 
TCAGTCAAGG AGAATGTGGA TAGAATGAAT TCTGACAAAG GCTCAAGCAG TGGGGGTAAG 
GGCTCTGAGA AGCAGGAGTT CAGAAACCCG AAACAAGAAC TTCGAGATCG TGGTCGTGGT 
ATTCTGATTC TGCCTGCCCA CACTGCCCTA TCTGTCAGTT CATCAGGTTC TCCGGAGTCT 
ACACCTTTGG GACCTAGACT TTTATTTGGA TCTGGTAGTA AGGGATCTCG GAGTTGGGGC 
CGTGGAGGCA CAACCCGCCG ACTATGGGAC CCAAACAATC CTGATCAGAA GCCTGCTCTG 
AAAAGCCAGA CACCTCAGCT ACATTTCTTG GACACAGATG ATGAAATTAG CCCTACATCC 
TGGGGTGATT CACGTCAGGC CCAAGCATCT TTCTATAAAT TTCAAAACTC TGACAACCCC 
TATTATTATC CTCGGACACC AGGCCCTGCC TCTCAGTATC CCTATACAGG CTATAGTCCT 
CTGCAATACC CAGTGGGCCC TACAAATGGT ATGTATCCAG GGCCTTACTA CCCAGGCTAT 
CCTGCCCCCT CAGGACAGTA TGTATGTAGC CCTCTCCCTG CTAGTACCAT GAGTCCTGAG 
GAAATAGAAC AGCACGTGCG GAACATGCAG CAACAGGAGC TCCATAGGCT TCTCCGAGTG 
GCTGACAACC AGGAACTGCA GCTCAGCAAC CTGCTTTCCA GGGACCGCAT CAGCACTGAG 
GGCATGGAGA AGATGGCTCA GCTAAGAACG GAACTCCTGC AGCTGTACGA GCGCTGTATT 
CTATTGGATA TTGAATTCTC TGACAGTCAG AATGTAGATC AGATCCTGTG GAAGAATGCT 
TTCTATCAGG TGATTGAGAA ATTCAGGCAG CTTCTCAAGG ATCCAAATAT TGAGAACCCA 
GAACAGATTC GGAACAGACT CTTGGAACTC TTAGATGAGG GCAGTGACTT CTTTGATAGT 
TTGCTTCAGA AACTACAGGT TACTTACAAG TTCAAACTGG AGGACTACAT GGATGGGCTT 
GCCATTCGAA GCAAACCATT ACGAAAAACA GTGAAATATG CCTTGATCAG TGCTCAGCGC 
AGTATGATAT GTCAAGGAGA TATCTCTAGG TATCGGGAGC AAGCCAATGA CACAGCAAAC 
TATGGGAAGG CTCGCAGTTG GTATCTGAAG GCCCAGCATA TTGCTCCCAA GAATGGGCGC 
CCCTATAACC AGTTGGCTTT ACTGGCAGTG TATACGAGGA GGAAGCTTGA TGCTGTGTAT 
TACTATATGC GCAGTTTAGC AGCCAGCAAC CCTATCCTGA CTGCCAAGGA GAGTCTCATG 
AGTTTATTTG AAGAGACTAA GCGAAAAGCC GAACAGATGG AAAAGAAGCA GCATGAGGAG 
TTTGATCTGA GTCCTGATCA GTGGCGTAAA GGAAAGAAGT CTACTTTCCG GCATGTTGGG 
GATGACACTA CTCGCCTGGA GATCTGGATT CATCCATCAC ATTCTCGGTC CTCCCAGGGC 
ACTGAGTCTG GGAAGGATTC TGAGCAGGAG AATGGTCTGG GCAGCCTGAG CCCCAGTGAT 
GTAAGTTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246928.1
CDS	1279..4110
Translation	MLLLPVRPPSFGEGRQEGAGKRVGVGERAPPVRRGFLAARGGGGVAAAVAAAAKMAEGLERVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKTKEASGNEEFKDEIVNDRDASAVGNDTQLIKVCKELDSQQQNGPIDAENSQAQETFSKTVGLEDRSLKIIKRIKKPDLQIYQPGRRLQTVTKESAGRADEEEILNQVEQLTMEGDECRGEAIKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKGEGSKKVTDDSVQGKPGSVKRYSRSDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSMSSTDSLDEDRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQKSNGKENRGALRVTFDAEAMSKDSPVVRSVKENVDRMNSDKGSSSGGKGSEKQEFRNPKQELRDRGRGILILPAHTALSVSSSGSPESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEISPTSWGDSRQAQASFYKFQNSDNPYYYPRTPGPASQYPYTGYSPLQYPVGPTNGMYPGPYYPGYPAPSGQYVCSPLPASTMSPEEIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNIENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHSRSSQGTESGKDSEQENGLGSLSPSDVSS

Target ORF information:

RefSeq Version	XM_006246866.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246866.3

ORF Insert Sequence:

ATGCTTTTGC TCCCAGTGCG GCCACCGTCG TTTGGGGAGG GCAGGCAGGA GGGGGCGGGG 
AAAAGGGTGG GAGTGGGTGA GCGCGCGCCG CCCGTCCGTC GTGGTTTCCT GGCTGCGCGC 
GGCGGTGGTG GAGTCGCCGC AGCTGTAGCA GCCGCCGCGA AGATGGCGGA GGGGTTGGAG 
CGTGTGCGGA TCTCCGCGTC GGAACTGCGA GGGATCCTGG CCACTCTGGC TCCGCAGGCC 
GGGAGCAGAG AAAACATGAA GGAACTAAAG GAACCCAGGC AGCGCAAAGA TAACAGGCGC 
CCAGATTTGG AAATCTACAA GCCTGGGCTT TCTCGACTGA GAAACAGACC TAAAACCAAG 
GAGGCTTCTG GGAATGAGGA ATTCAAAGAT GAGATTGTGA ATGACAGAGA TGCTTCTGCT 
GTTGGGAATG ATACACAACT TATTAAAGTT TGCAAGGAAT TGGACAGCCA ACAGCAAAAT 
GGCCCTATAG ATGCAGAAAA TAGTCAGGCA CAGGAGACTT TCTCAAAGAC TGTTGGACTA 
GAGGACCGAA GTCTAAAAAT CATCAAGAGA ATCAAGAAAC CAGACCTGCA GATCTACCAG 
CCTGGAAGGC GGTTGCAGAC TGTTACCAAA GAGTCAGCGG GTAGGGCAGA TGAAGAAGAA 
ATCCTCAACC AAGTGGAGCA GTTGACGATG GAAGGGGATG AGTGTAGGGG AGAAGCTATA 
AAAGAAGAAG TTATCAACAA ACCGGATAAA ACCGAGATAG AAAAGAGCCA AAGTAATGAC 
CGTGTAAGAA CTGCCAAGGG AGAAAAGGGG AAAAAGATTG ATAAGGGGGA GGGGTCAAAA 
AAGGTGACTG ATGACTCTGT CCAAGGAAAG CCTGGCTCTG TAAAGAGGTA CTCACGATCA 
GACAAGAGAA GGAACCGCTA TCGCACTTGC AGTACCAGCT CAGCTGGTAG CAACAACAGT 
GCAGAGGGAG CTGGCCTGAC TGATAATGGA TGTCGCCGGC GGCGCCAGGA CCGGACCAAA 
GAGAGGCCAC GACTGAAGAA ACAGGTATCT ATGTCCTCAA CTGATTCCTT AGATGAGGAC 
AGAGTTACTG AGCCTGATGG ATTAGGGTCC AGGAGGAGCT CAGAAAGGAA GAAGCATTTA 
GACAGAAATT GGTCTGGCCG AGGTGAGGGT GAACAGAAAA GCAATGGTAA AGAAAACCGA 
GGCGCCCTTC GTGTCACTTT TGATGCAGAA GCCATGAGTA AAGACTCCCC TGTGGTAAGG 
TCAGTCAAGG AGAATGTGGA TAGAATGAAT TCTGACAAAG GCTCAAGCAG TGGGGGTAAG 
GGCTCTGAGA AGCAGGAGTT CAGAAACCCG AAACAAGAAC TTCGAGATCG TGGTCGTGGT 
ATTCTGATTC TGCCTGCCCA CACTGCCCTA TCTGTCAGTT CATCAGGTTC TCCGGAGTCT 
ACACCTTTGG GACCTAGACT TTTATTTGGA TCTGGTAGTA AGGGATCTCG GAGTTGGGGC 
CGTGGAGGCA CAACCCGCCG ACTATGGGAC CCAAACAATC CTGATCAGAA GCCTGCTCTG 
AAAAGCCAGA CACCTCAGCT ACATTTCTTG GACACAGATG ATGAAATTAG CCCTACATCC 
TGGGGTGATT CACGTCAGGC CCAAGCATCT TTCTATAAAT TTCAAAACTC TGACAACCCC 
TATTATTATC CTCGGACACC AGGCCCTGCC TCTCAGTATC CCTATACAGG CTATAGTCCT 
CTGCAATACC CAGTGGGCCC TACAAATGGT ATGTATCCAG GGCCTTACTA CCCAGGCTAT 
CCTGCCCCCT CAGGACAGTA TGTATGTAGC CCTCTCCCTG CTAGTACCAT GAGTCCTGAG 
GAAATAGAAC AGCACGTGCG GAACATGCAG CAACAGGAGC TCCATAGGCT TCTCCGAGTG 
GCTGACAACC AGGAACTGCA GCTCAGCAAC CTGCTTTCCA GGGACCGCAT CAGCACTGAG 
GGCATGGAGA AGATGGCTCA GCTAAGAACG GAACTCCTGC AGCTGTACGA GCGCTGTATT 
CTATTGGATA TTGAATTCTC TGACAGTCAG AATGTAGATC AGATCCTGTG GAAGAATGCT 
TTCTATCAGG TGATTGAGAA ATTCAGGCAG CTTCTCAAGG ATCCAAATAT TGAGAACCCA 
GAACAGATTC GGAACAGACT CTTGGAACTC TTAGATGAGG GCAGTGACTT CTTTGATAGT 
TTGCTTCAGA AACTACAGGT TACTTACAAG TTCAAACTGG AGGACTACAT GGATGGGCTT 
GCCATTCGAA GCAAACCATT ACGAAAAACA GTGAAATATG CCTTGATCAG TGCTCAGCGC 
AGTATGATAT GTCAAGGAGA TATCTCTAGG TATCGGGAGC AAGCCAATGA CACAGCAAAC 
TATGGGAAGG CTCGCAGTTG GTATCTGAAG GCCCAGCATA TTGCTCCCAA GAATGGGCGC 
CCCTATAACC AGTTGGCTTT ACTGGCAGTG TATACGAGGA GGAAGCTTGA TGCTGTGTAT 
TACTATATGC GCAGTTTAGC AGCCAGCAAC CCTATCCTGA CTGCCAAGGA GAGTCTCATG 
AGTTTATTTG AAGAGACTAA GCGAAAAGCC GAACAGATGG AAAAGAAGCA GCATGAGGAG 
TTTGATCTGA GTCCTGATCA GTGGCGTAAA GGAAAGAAGT CTACTTTCCG GCATGTTGGG 
GATGACACTA CTCGCCTGGA GATCTGGATT CATCCATCAC ATTCTCGGTC CTCCCAGGGC 
ACTGAGTCTG GGAAGGATTC TGAGCAGGAG AATGGTCTGG GCAGCCTGAG CCCCAGTGAT 
GTAAGTTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Smg6 ( NM_001105808.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099278.1 Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), mRNA.

Price & Availability↑

CloneID	ORa11455
Clone ID Related Accession (Same CDS sequence)	NM_001105808.1
Accession Version	NM_001105808.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	telomerase-binding protein EST1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 3, 2007 this sequence version replaced XM_001080444.1, XM_220702.4. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTTTTGC TCCCAGTGCG GCCACCGTCG TTTGGGGAGG GCAGGCAGGA GGGGGCGGGG 
AAAAGGGTGG GAGTGGGTGA GCGCGCGCCG CCCGTCCGTC GTGGTTTCCT GGCTGCGCGC 
GGCGGTGGTG GAGTCGCCGC AGCTGTAGCA GCCGCCGCGA AGATGGCGGA GGGGTTGGAG 
CGTGTGCGGA TCTCCGCGTC GGAACTGCGA GGGATCCTGG CCACTCTGGC TCCGCAGGCC 
GGGAGCAGAG AAAACATGAA GGAACTAAAG GAACCCAGGC AGCGCAAAGA TAACAGGCGC 
CCAGATTTGG AAATCTACAA GCCTGGGCTT TCTCGACTGA GAAACAGACC TAAAACCAAG 
GAGGCTTCTG GGAATGAGGA ATTCAAAGAT GAGATTGTGA ATGACAGAGA TGCTTCTGCT 
GTTGGGAATG ATACACAACT TATTAAAGTT TGCAAGGAAT TGGACAGCCA ACAGCAAAAT 
GGCCCTATAG ATGCAGAAAA TAGTCAGGCA CAGGAGACTT TCTCAAAGAC TGTTGGACTA 
GAGGACCGAA GTCTAAAAAT CATCAAGAGA ATCAAGAAAC CAGACCTGCA GATCTACCAG 
CCTGGAAGGC GGTTGCAGAC TGTTACCAAA GAGTCAGCGG GTAGGGCAGA TGAAGAAGAA 
ATCCTCAACC AAGTGGAGCA GTTGACGATG GAAGGGGATG AGTGTAGGGG AGAAGCTATA 
AAAGAAGAAG TTATCAACAA ACCGGATAAA ACCGAGATAG AAAAGAGCCA AAGTAATGAC 
CGTGTAAGAA CTGCCAAGGG AGAAAAGGGG AAAAAGATTG ATAAGGGGGA GGGGTCAAAA 
AAGGTGACTG ATGACTCTGT CCAAGGAAAG CCTGGCTCTG TAAAGAGGTA CTCACGATCA 
GACAAGAGAA GGAACCGCTA TCGCACTTGC AGTACCAGCT CAGCTGGTAG CAACAACAGT 
GCAGAGGGAG CTGGCCTGAC TGATAATGGA TGTCGCCGGC GGCGCCAGGA CCGGACCAAA 
GAGAGGCCAC GACTGAAGAA ACAGGTATCT ATGTCCTCAA CTGATTCCTT AGATGAGGAC 
AGAGTTACTG AGCCTGATGG ATTAGGGTCC AGGAGGAGCT CAGAAAGGAA GAAGCATTTA 
GACAGAAATT GGTCTGGCCG AGGTGAGGGT GAACAGAAAA GCAATGGTAA AGAAAACCGA 
GGCGCCCTTC GTGTCACTTT TGATGCAGAA GCCATGAGTA AAGACTCCCC TGTGGTAAGG 
TCAGTCAAGG AGAATGTGGA TAGAATGAAT TCTGACAAAG GCTCAAGCAG TGGGGGTAAG 
GGCTCTGAGA AGCAGGAGTT CAGAAACCCG AAACAAGAAC TTCGAGATCG TGGTCGTGGT 
ATTCTGATTC TGCCTGCCCA CACTGCCCTA TCTGTCAGTT CATCAGGTTC TCCGGAGTCT 
ACACCTTTGG GACCTAGACT TTTATTTGGA TCTGGTAGTA AGGGATCTCG GAGTTGGGGC 
CGTGGAGGCA CAACCCGCCG ACTATGGGAC CCAAACAATC CTGATCAGAA GCCTGCTCTG 
AAAAGCCAGA CACCTCAGCT ACATTTCTTG GACACAGATG ATGAAATTAG CCCTACATCC 
TGGGGTGATT CACGTCAGGC CCAAGCATCT TTCTATAAAT TTCAAAACTC TGACAACCCC 
TATTATTATC CTCGGACACC AGGCCCTGCC TCTCAGTATC CCTATACAGG CTATAGTCCT 
CTGCAATACC CAGTGGGCCC TACAAATGGT ATGTATCCAG GGCCTTACTA CCCAGGCTAT 
CCTGCCCCCT CAGGACAGTA TGTATGTAGC CCTCTCCCTG CTAGTACCAT GAGTCCTGAG 
GAAATAGAAC AGCACGTGCG GAACATGCAG CAACAGGAGC TCCATAGGCT TCTCCGAGTG 
GCTGACAACC AGGAACTGCA GCTCAGCAAC CTGCTTTCCA GGGACCGCAT CAGCACTGAG 
GGCATGGAGA AGATGGCTCA GCTAAGAACG GAACTCCTGC AGCTGTACGA GCGCTGTATT 
CTATTGGATA TTGAATTCTC TGACAGTCAG AATGTAGATC AGATCCTGTG GAAGAATGCT 
TTCTATCAGG TGATTGAGAA ATTCAGGCAG CTTCTCAAGG ATCCAAATAT TGAGAACCCA 
GAACAGATTC GGAACAGACT CTTGGAACTC TTAGATGAGG GCAGTGACTT CTTTGATAGT 
TTGCTTCAGA AACTACAGGT TACTTACAAG TTCAAACTGG AGGACTACAT GGATGGGCTT 
GCCATTCGAA GCAAACCATT ACGAAAAACA GTGAAATATG CCTTGATCAG TGCTCAGCGC 
AGTATGATAT GTCAAGGAGA TATCTCTAGG TATCGGGAGC AAGCCAATGA CACAGCAAAC 
TATGGGAAGG CTCGCAGTTG GTATCTGAAG GCCCAGCATA TTGCTCCCAA GAATGGGCGC 
CCCTATAACC AGTTGGCTTT ACTGGCAGTG TATACGAGGA GGAAGCTTGA TGCTGTGTAT 
TACTATATGC GCAGTTTAGC AGCCAGCAAC CCTATCCTGA CTGCCAAGGA GAGTCTCATG 
AGTTTATTTG AAGAGACTAA GCGAAAAGCC GAACAGATGG AAAAGAAGCA GCATGAGGAG 
TTTGATCTGA GTCCTGATCA GTGGCGTAAA GGAAAGAAGT CTACTTTCCG GCATGTTGGG 
GATGACACTA CTCGCCTGGA GATCTGGATT CATCCATCAC ATTCTCGGTC CTCCCAGGGC 
ACTGAGTCTG GGAAGGATTC TGAGCAGGAG AATGGTCTGG GCAGCCTGAG CCCCAGTGAT 
CTGAACAAAA GGTTCATCCT CAGTTTTCTC CATGCCCATG GGAAGCTGTT TACCCGGATT 
GGGATGGAGA CATTCCCTGC AGTGGCTGAG AAGGTCCTTA AGGAGTTCCA AGTATTGCTG 
CAGCACAGCC CATCTCCTAT TGGAAGCACT CGTATGCTGC AGCTCATGAC CATCAACATG 
TTTGCTGTAC ATAATTCCCA GTTGAAAGAC TGCTTCTCAG AGGAGTGTCG TTCTGTGATC 
CAGGAACAAG CTGCATCCTT GGGCTTGGCT ATGTTTTCTC TACTGGTCCA GCGCTGCACA 
TGCTTACTTA AGGACTCTGC CAAAGCTCAG CTGTCCTCTC CTGAGGACCA AGAGGACCAA 
GATGACATCA AGGTATCTTC CTTCGTCCCG GACCTAAAGG AGCTGCTCCC CAGTGTGAAA 
GTCTGGTCAG ATTGGATGCT TGGCTACCCA GACACCTGGA ATCCTCCGCC CACATCTTTG 
GATCTGCCCT TGCAGGTTGC TGTGGATGTA TGGTCAACAC TTGCTGATTT CTGTAACATA 
CTGACTGCAG TGAATCAGTC TGAGGTGCCA CTGTACAAGG ACCCAGATGA TGACCTCACC 
CTGCTTATCC TGGAAGAGGA TCGGCTTCTC TCTGGCTTTG TCCCCTTGCT GGCTGCCCCT 
CAGGACCCCT GCTACGTGGA GAAAACCTCG GATAAGGTTA TTGCAGCTGA CTGCAAAAGG 
GTCACAGTGC TGAAGTATTT TCTGGAAGCC CTTTGTGGAC AAGAAGAGCC TCTGCTGGCA 
TTCAAGGGTG GAAAATATGT GTCAGTGGCA CCCGTCCCAG ACACCATGGG AAAGGAAATG 
GGAATCCAAG AGGGAAAACA ACTGGAAGAT GAGGAAGAAG ATGTGGTGAT TGAAGACTTT 
GAGGAAGATT CAGAGGCTGA AGGTAGTGGG GGTGAGGATG ACATCAGGGA ACTTCGGGCC 
AAGAAGCTGG CTCTAGCAAG GAAAATAGCT GAACAGCAGC GTCGCCAGGA AAAGATCCAG 
GCTGTTTTGG AAGACCAGAG TCAGATGAGA CAGATGGAGC TGGAGATCAG ACCCTTGTTC 
CTCGTACCAG ATACCAACGG CTTCATTGAC CACCTGGCCA GTCTAGCTCG GCTGCTGGAG 
AGCAGGAAGT ACATCCTGGT GGTGCCCCTC ATCGTGATCA ATGAGCTGGA TGGCCTCGCC 
AAAGGGCAGG AGACAGACCA CCGGGCTGGG GGCTATGCCC GTGTGGTGCA AGAAAAGGCC 
CGAAAATCCA TCGAGTTCCT TGAACGGAGA TTTGAGAGTC GGGACTCCTG CCTGCGGGCC 
TTGACCAGCC GTGGCAATGA ACTTGAATCT ATCGCCTTCC GAAGTGAGGA CATTACTGGA 
CAGCTGGGCA ACAACGATGA CCTGATCCTT TCCTGCTGCC TGCACTACTG CAAAGACAAA 
GCTAAGGACT ACATGCCCAC CAGCAAAGAG GAGCCCATCC GCTTGCTACG GGAAGTGGTG 
TTGCTGACGG ATGATCGGAA CCTTCGTGTA AAGGCACTAA CAAGGAATGT GCCTGTGAGG 
GACATCCCAG CCTTCCTTAC GTGGGCCCAG GTGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099278.1
CDS	420..4838
Translation	MLLLPVRPPSFGEGRQEGAGKRVGVGERAPPVRRGFLAARGGGGVAAAVAAAAKMAEGLERVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKTKEASGNEEFKDEIVNDRDASAVGNDTQLIKVCKELDSQQQNGPIDAENSQAQETFSKTVGLEDRSLKIIKRIKKPDLQIYQPGRRLQTVTKESAGRADEEEILNQVEQLTMEGDECRGEAIKEEVINKPDKTEIEKSQSNDRVRTAKGEKGKKIDKGEGSKKVTDDSVQGKPGSVKRYSRSDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSMSSTDSLDEDRVTEPDGLGSRRSSERKKHLDRNWSGRGEGEQKSNGKENRGALRVTFDAEAMSKDSPVVRSVKENVDRMNSDKGSSSGGKGSEKQEFRNPKQELRDRGRGILILPAHTALSVSSSGSPESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEISPTSWGDSRQAQASFYKFQNSDNPYYYPRTPGPASQYPYTGYSPLQYPVGPTNGMYPGPYYPGYPAPSGQYVCSPLPASTMSPEEIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNIENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHSRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAASLGLAMFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGIQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG

Target ORF information:

RefSeq Version	NM_001105808.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SMG6 nonsense mediated mRNA decay factor (Smg6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105808.1

ORF Insert Sequence:

ATGCTTTTGC TCCCAGTGCG GCCACCGTCG TTTGGGGAGG GCAGGCAGGA GGGGGCGGGG 
AAAAGGGTGG GAGTGGGTGA GCGCGCGCCG CCCGTCCGTC GTGGTTTCCT GGCTGCGCGC 
GGCGGTGGTG GAGTCGCCGC AGCTGTAGCA GCCGCCGCGA AGATGGCGGA GGGGTTGGAG 
CGTGTGCGGA TCTCCGCGTC GGAACTGCGA GGGATCCTGG CCACTCTGGC TCCGCAGGCC 
GGGAGCAGAG AAAACATGAA GGAACTAAAG GAACCCAGGC AGCGCAAAGA TAACAGGCGC 
CCAGATTTGG AAATCTACAA GCCTGGGCTT TCTCGACTGA GAAACAGACC TAAAACCAAG 
GAGGCTTCTG GGAATGAGGA ATTCAAAGAT GAGATTGTGA ATGACAGAGA TGCTTCTGCT 
GTTGGGAATG ATACACAACT TATTAAAGTT TGCAAGGAAT TGGACAGCCA ACAGCAAAAT 
GGCCCTATAG ATGCAGAAAA TAGTCAGGCA CAGGAGACTT TCTCAAAGAC TGTTGGACTA 
GAGGACCGAA GTCTAAAAAT CATCAAGAGA ATCAAGAAAC CAGACCTGCA GATCTACCAG 
CCTGGAAGGC GGTTGCAGAC TGTTACCAAA GAGTCAGCGG GTAGGGCAGA TGAAGAAGAA 
ATCCTCAACC AAGTGGAGCA GTTGACGATG GAAGGGGATG AGTGTAGGGG AGAAGCTATA 
AAAGAAGAAG TTATCAACAA ACCGGATAAA ACCGAGATAG AAAAGAGCCA AAGTAATGAC 
CGTGTAAGAA CTGCCAAGGG AGAAAAGGGG AAAAAGATTG ATAAGGGGGA GGGGTCAAAA 
AAGGTGACTG ATGACTCTGT CCAAGGAAAG CCTGGCTCTG TAAAGAGGTA CTCACGATCA 
GACAAGAGAA GGAACCGCTA TCGCACTTGC AGTACCAGCT CAGCTGGTAG CAACAACAGT 
GCAGAGGGAG CTGGCCTGAC TGATAATGGA TGTCGCCGGC GGCGCCAGGA CCGGACCAAA 
GAGAGGCCAC GACTGAAGAA ACAGGTATCT ATGTCCTCAA CTGATTCCTT AGATGAGGAC 
AGAGTTACTG AGCCTGATGG ATTAGGGTCC AGGAGGAGCT CAGAAAGGAA GAAGCATTTA 
GACAGAAATT GGTCTGGCCG AGGTGAGGGT GAACAGAAAA GCAATGGTAA AGAAAACCGA 
GGCGCCCTTC GTGTCACTTT TGATGCAGAA GCCATGAGTA AAGACTCCCC TGTGGTAAGG 
TCAGTCAAGG AGAATGTGGA TAGAATGAAT TCTGACAAAG GCTCAAGCAG TGGGGGTAAG 
GGCTCTGAGA AGCAGGAGTT CAGAAACCCG AAACAAGAAC TTCGAGATCG TGGTCGTGGT 
ATTCTGATTC TGCCTGCCCA CACTGCCCTA TCTGTCAGTT CATCAGGTTC TCCGGAGTCT 
ACACCTTTGG GACCTAGACT TTTATTTGGA TCTGGTAGTA AGGGATCTCG GAGTTGGGGC 
CGTGGAGGCA CAACCCGCCG ACTATGGGAC CCAAACAATC CTGATCAGAA GCCTGCTCTG 
AAAAGCCAGA CACCTCAGCT ACATTTCTTG GACACAGATG ATGAAATTAG CCCTACATCC 
TGGGGTGATT CACGTCAGGC CCAAGCATCT TTCTATAAAT TTCAAAACTC TGACAACCCC 
TATTATTATC CTCGGACACC AGGCCCTGCC TCTCAGTATC CCTATACAGG CTATAGTCCT 
CTGCAATACC CAGTGGGCCC TACAAATGGT ATGTATCCAG GGCCTTACTA CCCAGGCTAT 
CCTGCCCCCT CAGGACAGTA TGTATGTAGC CCTCTCCCTG CTAGTACCAT GAGTCCTGAG 
GAAATAGAAC AGCACGTGCG GAACATGCAG CAACAGGAGC TCCATAGGCT TCTCCGAGTG 
GCTGACAACC AGGAACTGCA GCTCAGCAAC CTGCTTTCCA GGGACCGCAT CAGCACTGAG 
GGCATGGAGA AGATGGCTCA GCTAAGAACG GAACTCCTGC AGCTGTACGA GCGCTGTATT 
CTATTGGATA TTGAATTCTC TGACAGTCAG AATGTAGATC AGATCCTGTG GAAGAATGCT 
TTCTATCAGG TGATTGAGAA ATTCAGGCAG CTTCTCAAGG ATCCAAATAT TGAGAACCCA 
GAACAGATTC GGAACAGACT CTTGGAACTC TTAGATGAGG GCAGTGACTT CTTTGATAGT 
TTGCTTCAGA AACTACAGGT TACTTACAAG TTCAAACTGG AGGACTACAT GGATGGGCTT 
GCCATTCGAA GCAAACCATT ACGAAAAACA GTGAAATATG CCTTGATCAG TGCTCAGCGC 
AGTATGATAT GTCAAGGAGA TATCTCTAGG TATCGGGAGC AAGCCAATGA CACAGCAAAC 
TATGGGAAGG CTCGCAGTTG GTATCTGAAG GCCCAGCATA TTGCTCCCAA GAATGGGCGC 
CCCTATAACC AGTTGGCTTT ACTGGCAGTG TATACGAGGA GGAAGCTTGA TGCTGTGTAT 
TACTATATGC GCAGTTTAGC AGCCAGCAAC CCTATCCTGA CTGCCAAGGA GAGTCTCATG 
AGTTTATTTG AAGAGACTAA GCGAAAAGCC GAACAGATGG AAAAGAAGCA GCATGAGGAG 
TTTGATCTGA GTCCTGATCA GTGGCGTAAA GGAAAGAAGT CTACTTTCCG GCATGTTGGG 
GATGACACTA CTCGCCTGGA GATCTGGATT CATCCATCAC ATTCTCGGTC CTCCCAGGGC 
ACTGAGTCTG GGAAGGATTC TGAGCAGGAG AATGGTCTGG GCAGCCTGAG CCCCAGTGAT 
CTGAACAAAA GGTTCATCCT CAGTTTTCTC CATGCCCATG GGAAGCTGTT TACCCGGATT 
GGGATGGAGA CATTCCCTGC AGTGGCTGAG AAGGTCCTTA AGGAGTTCCA AGTATTGCTG 
CAGCACAGCC CATCTCCTAT TGGAAGCACT CGTATGCTGC AGCTCATGAC CATCAACATG 
TTTGCTGTAC ATAATTCCCA GTTGAAAGAC TGCTTCTCAG AGGAGTGTCG TTCTGTGATC 
CAGGAACAAG CTGCATCCTT GGGCTTGGCT ATGTTTTCTC TACTGGTCCA GCGCTGCACA 
TGCTTACTTA AGGACTCTGC CAAAGCTCAG CTGTCCTCTC CTGAGGACCA AGAGGACCAA 
GATGACATCA AGGTATCTTC CTTCGTCCCG GACCTAAAGG AGCTGCTCCC CAGTGTGAAA 
GTCTGGTCAG ATTGGATGCT TGGCTACCCA GACACCTGGA ATCCTCCGCC CACATCTTTG 
GATCTGCCCT TGCAGGTTGC TGTGGATGTA TGGTCAACAC TTGCTGATTT CTGTAACATA 
CTGACTGCAG TGAATCAGTC TGAGGTGCCA CTGTACAAGG ACCCAGATGA TGACCTCACC 
CTGCTTATCC TGGAAGAGGA TCGGCTTCTC TCTGGCTTTG TCCCCTTGCT GGCTGCCCCT 
CAGGACCCCT GCTACGTGGA GAAAACCTCG GATAAGGTTA TTGCAGCTGA CTGCAAAAGG 
GTCACAGTGC TGAAGTATTT TCTGGAAGCC CTTTGTGGAC AAGAAGAGCC TCTGCTGGCA 
TTCAAGGGTG GAAAATATGT GTCAGTGGCA CCCGTCCCAG ACACCATGGG AAAGGAAATG 
GGAATCCAAG AGGGAAAACA ACTGGAAGAT GAGGAAGAAG ATGTGGTGAT TGAAGACTTT 
GAGGAAGATT CAGAGGCTGA AGGTAGTGGG GGTGAGGATG ACATCAGGGA ACTTCGGGCC 
AAGAAGCTGG CTCTAGCAAG GAAAATAGCT GAACAGCAGC GTCGCCAGGA AAAGATCCAG 
GCTGTTTTGG AAGACCAGAG TCAGATGAGA CAGATGGAGC TGGAGATCAG ACCCTTGTTC 
CTCGTACCAG ATACCAACGG CTTCATTGAC CACCTGGCCA GTCTAGCTCG GCTGCTGGAG 
AGCAGGAAGT ACATCCTGGT GGTGCCCCTC ATCGTGATCA ATGAGCTGGA TGGCCTCGCC 
AAAGGGCAGG AGACAGACCA CCGGGCTGGG GGCTATGCCC GTGTGGTGCA AGAAAAGGCC 
CGAAAATCCA TCGAGTTCCT TGAACGGAGA TTTGAGAGTC GGGACTCCTG CCTGCGGGCC 
TTGACCAGCC GTGGCAATGA ACTTGAATCT ATCGCCTTCC GAAGTGAGGA CATTACTGGA 
CAGCTGGGCA ACAACGATGA CCTGATCCTT TCCTGCTGCC TGCACTACTG CAAAGACAAA 
GCTAAGGACT ACATGCCCAC CAGCAAAGAG GAGCCCATCC GCTTGCTACG GGAAGTGGTG 
TTGCTGACGG ATGATCGGAA CCTTCGTGTA AAGGCACTAA CAAGGAATGT GCCTGTGAGG 
GACATCCCAG CCTTCCTTAC GTGGGCCCAG GTGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
BMC molecular biology1245(2011 Oct)
Sealey DC,Kostic AD,LeBel C,Pryde F,Harrington L

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.
Genes & development24(21)2440-50(2010 Nov)
Kashima I,Jonas S,Jayachandran U,Buchwald G,Conti E,Lupas AN,Izaurralde E

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells.
Nature structural & molecular biology16(1)49-55(2009 Jan)
Eberle AB,Lykke-Andersen S,M?hlemann O,Jensen TH

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan.
RNA (New York, N.Y.)14(12)2609-17(2008 Dec)
Huntzinger E,Kashima I,Fauser M,Sauli?re J,Izaurralde E

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase.
Nucleic acids research35(20)7011-22(2007)
Redon S,Reichenbach P,Lingner J

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Smg6 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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