| Gene Symbol | Mks1 |
| Entrez Gene ID | 287612 |
| Full Name | Meckel syndrome, type 1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
The following Mks1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mks1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa08965 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001034917.2 | |
| Accession Version | NM_001034917.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1686bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-18 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | Meckel syndrome type 1 protein homolog | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN948264.1 and BC099806.1. On Sep 29, 2009 this sequence version replaced NM_001034917.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099806.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCGGAAG CCGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001030089.2 |
| CDS | 1..1686 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001034917.2 |
1 | ATGGCGGAAG CCGTCTGGAG CACTGACACC GGCGAGGCCG TGTATCGCTC CCGGGACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa57247 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017597129.1 | |
| Accession Version | XM_017597129.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | Meckel syndrome type 1 protein homolog isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTCAGGCG GCGGCGCCAG GACAGGCGAG GGGGAGGGCA GCAAACTCAA GTCTCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017452618.1 |
| CDS | 149..1351 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017597129.1 |
1 | ATGTCAGGCG GCGGCGCCAG GACAGGCGAG GGGGAGGGCA GCAAACTCAA GTCTCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. |
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. |
Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome. |
Founder mutations and genotype-phenotype correlations in Meckel-Gruber syndrome and associated ciliopathies. |
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. |
