Gene Symbol | Fermt2 |
Entrez Gene ID | 289992 |
Full Name | fermitin family member 2 |
Synonyms | Plekhc1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Fermt2 cDNA ORF clone
Gene Symbol | Fermt2 |
Entrez Gene ID | 289992 |
Full Name | fermitin family member 2 |
Synonyms | Plekhc1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006251756.3 | XP_006251818.1 | fermitin family homolog 2 isoform X1 |
XM_006251755.2 | XP_006251817.1 | fermitin family homolog 2 isoform X1 |
NM_001011915.1 | NP_001011915.1 | fermitin family homolog 2 |
XM_006251758.2 | XP_006251820.1 | fermitin family homolog 2 isoform X3 |
XM_006251759.2 | XP_006251821.1 | fermitin family homolog 2 isoform X4 |
XM_006251760.2 | XP_006251822.1 | fermitin family homolog 2 isoform X5 |
XM_006251757.2 | XP_006251819.1 | fermitin family homolog 2 isoform X2 |
XM_006251761.3 | XP_006251823.1 | fermitin family homolog 2 isoform X6 |
FERMT2 | XP_001082931.1 | |
Mus musculus (house mouse) | Fermt2 | NP_666166.2 |
Bos taurus (cattle) | FERMT2 | NP_001094734.1 |
Drosophila melanogaster (fruit fly) | Fit2 | NP_648947.1 |
Drosophila melanogaster (fruit fly) | Fit1 | NP_647858.2 |
Pan troglodytes (chimpanzee) | FERMT2 | XP_003314374.1 |
Gallus gallus (chicken) | PLEKHC1 | XP_004936582.1 |
Danio rerio (zebrafish) | fermt2 | NP_001243144.1 |
Canis lupus familiaris (dog) | FERMT2 | XP_547815.5 |
Rattus norvegicus (Norway rat) | Fermt2 | NP_001011915.1 |
Caenorhabditis elegans (roundworm) | unc-112 | NP_506628.1 |
Homo sapiens (human) | FERMT2 | NP_001128471.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002054 | XP_320993.2 |
Xenopus tropicalis (tropical clawed frog) | fermt2 | XP_004917211.1 |
The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
Rogg M, Yasuda-Yamahara M, Abed A, Dinse P, Helmst?dter M, Conzelmann AC, Frimmel J, Sellung D, Biniossek ML, Kretz O, Grahammer F, Schilling O, Huber TB, Schell C
Scientific reports7(1)15910(2017 Nov)
Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling.
Wu X, Liu W, Jiang H, Chen J, Wang J, Zhu R, Li B
International journal of molecular medicine37(2)436-44(2016 Feb)
Kindlin-2 interacts with ?-actinin-2 and ?1 integrin to maintain the integrity of the Z-disc in cardiac muscles.
Qi L, Yu Y, Chi X, Xu W, Lu D, Song Y, Zhang Y, Zhang H
FEBS letters589(16)2155-62(2015 Jul)
Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood DA, Campbell ID, Critchley DR
Nature reviews. Molecular cell biology14(8)503-17(2013 Aug)
Kindlin 2 forms a transcriptional complex with ?-catenin and TCF4 to enhance Wnt signalling.
Yu Y, Wu J, Wang Y, Zhao T, Ma B, Liu Y, Fang W, Zhu WG, Zhang H
EMBO reports13(8)750-8(2012 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study demonstrated that kindlin-2 plays a critical role in VSMC proliferation, migration and intimal hyperplasia via Wnt signaling. Therefore, blocking the activity of kindlin-2 represents a novel therapeutic strategy for vascular injury.
Title: Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling.
Data suggest that kindlin-2 (Kind2/Fermt2) interacts with actin alpha 2 (Actn2) and integrin beta 1 (Itgb1) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 leads to dissociation of Actn2 and Itgb1.
Title: Kindlin-2 interacts with ?-actinin-2 and ?1 integrin to maintain the integrity of the Z-disc in cardiac muscles.
The following Fermt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fermt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa01512 | |
Clone ID Related Accession (Same CDS sequence) | NM_001011915.1 | |
Accession Version | NM_001011915.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2043bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-18 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083876.1. On Feb 11, 2005 this sequence version replaced XM_214148.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC083876.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001011915.1 |
CDS | 95..2137 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001011915.1 |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36566 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251761.3 | |
Accession Version | XM_006251761.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 isoform X6 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006251761.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAATATG TGAAGGTGAA AGTGAACTTC TCTGACCGAG TCTTCAAAGC TGTGTCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251823.1 |
CDS | 367..2172 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006251761.3 |
1 | ATGAAATATG TGAAGGTGAA AGTGAACTTC TCTGACCGAG TCTTCAAAGC TGTGTCGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36561 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251756.3 , XM_006251755.2 | |
Accession Version | XM_006251756.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2121bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006251756.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251818.1 |
CDS | 94..2214 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006251756.3 |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36561 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251756.3 , XM_006251755.2 | |
Accession Version | XM_006251755.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2121bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006251755.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251817.1 |
CDS | 120..2240 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006251755.2 |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36562 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251757.2 | |
Accession Version | XM_006251757.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2097bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006251757.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251819.1 |
CDS | 120..2216 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006251757.2 |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36563 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251758.2 | |
Accession Version | XM_006251758.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006251758.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251820.1 |
CDS | 120..2207 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006251758.2 |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36564 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251759.2 | |
Accession Version | XM_006251759.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2076bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006251759.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251821.1 |
CDS | 120..2195 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006251759.2 |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36565 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251760.2 | |
Accession Version | XM_006251760.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2064bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | fermitin family homolog 2 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006251760.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251822.1 |
CDS | 120..2183 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006251760.2 |
1 | ATGGCTCTGG ACGGGATAAG GATGCCAGAT GGCTGCTACG CGGACGGGAC GTGGGAACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton. |
Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling. |
Kindlin-2 interacts with ?-actinin-2 and ?1 integrin to maintain the integrity of the Z-disc in cardiac muscles. |
Talins and kindlins: partners in integrin-mediated adhesion. |
Kindlin 2 forms a transcriptional complex with ?-catenin and TCF4 to enhance Wnt signalling. |