Penk cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Penk |
| Entrez Gene ID | 29237 |
| Full Name | proenkephalin |
| Synonyms | Enk,Penk-rs,Penk1,Penk2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | neuropeptide hormone; plays a role in the responses to stress and pain perception [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_017139.1 | NP_058835.1 | proenkephalin-A precursor |
| XM_006237835.1 | XP_006237897.1 | proenkephalin-A isoform X1 |
| Mus musculus (house mouse) | Penk | NP_001002927.1 |
| Rattus norvegicus (Norway rat) | Penk | NP_058835.1 |
| Danio rerio (zebrafish) | penka | NP_956377.1 |
| Gallus gallus (chicken) | PENK | XP_419213.1 |
| Xenopus tropicalis (tropical clawed frog) | penk | NP_001015744.2 |
| Homo sapiens (human) | PENK | NP_006202.1 |
| Pan troglodytes (chimpanzee) | PENK | XP_001155627.1 |
| LOC696649 | XP_002808525.1 | |
| Canis lupus familiaris (dog) | PENK | XP_003640059.2 |
| Bos taurus (cattle) | PENK | NP_776566.1 |
Related articles in PubMed
[Overexpression of PPENK reduces myocardial ischemia reperfusion injury by promoting mitophagy in rats].
Wang Y, Lu X, Zhao P, Jiang J, Yao L
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology33(10)1335-1340(2017 Oct)
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.
Frederick A, Goldsmith J, de Zavalia N, Amir S
PloS one12(4)e0176279(2017)
Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
Sgroi S, Capper-Loup C, Paganetti P, Kaelin-Lang A
Experimental neurology28080-8(2016 Jun)
Common effects of fat, ethanol, and nicotine on enkephalin in discrete areas of the brain.
Chang GQ, Karatayev O, Barson JR, Liang SC, Leibowitz SF
Neuroscience277665-78(2014 Sep)
Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia.
Poulin JF, Laforest S, Drolet G
Stress (Amsterdam, Netherlands)17(1)88-96(2014 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported.
Title: Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.
The findings of thus study suggest that, in parkinsonian animals treated with l-DOPA, high levels of PPENK are a prerequisite for a locomotor sensitization to l-DOPA treatment
Title: Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
results suggest that a DeltaFosB-mediated downregulation of enkephalin in the nucleus accumbens might underlie the susceptibility to chronic stress
Title: Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia.
we have demonstrated that ENKergic neurons facilitate unconditioned fear and anxiety through ENK release
Title: Enkephalin knockdown in the central amygdala nucleus reduces unconditioned fear and anxiety.
enkephalin surges and mu opioid stimulation in the same anteromedial dorsal neostriatumregion contribute to signaling the opportunity to eat a sensory reward and to causally generating increased consumption of that reward.
Title: Enkephalin surges in dorsal neostriatum as a signal to eat.
The following Penk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Penk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa28028 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006237835.1 | |
| Accession Version | XM_006237835.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | proenkephalin-A isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTGCTAGCGC TTGGGTCCTG CCTCCTGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006237897.1 |
| CDS | 181..990 |
| Translation |
Target ORF information:
Target ORF information:
|
 XM_006237835.1 |
ORF Insert Sequence:
1 | ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTGCTAGCGC TTGGGTCCTG CCTCCTGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa12991 | |
| Clone ID Related Accession (Same CDS sequence) | NM_017139.1 | |
| Accession Version | NM_017139.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-20 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | proenkephalin-A precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y07503.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y07503.1, BC083563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTCGTAGCGC TTGGGTCCTG CCTCCTGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_058835.1 |
| CDS | 328..1137 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_017139.1 |
ORF Insert Sequence:
1 | ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTCGTAGCGC TTGGGTCCTG CCTCCTGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
[Overexpression of PPENK reduces myocardial ischemia reperfusion injury by promoting mitophagy in rats]. |
|
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain. |
|
Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats. |
|
Common effects of fat, ethanol, and nicotine on enkephalin in discrete areas of the brain. |
|
Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia. |