Penk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Penk
Entrez Gene ID	29237
Full Name	proenkephalin
Synonyms	Enk,Penk-rs,Penk1,Penk2
General protein information	Preferred Names proenkephalin Names proenkephalin-A enkephalin preproenkephalin 2 proenkephalin 1 proenkephalin 2 proenkephalin related sequence
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q12
Summary	neuropeptide hormone; plays a role in the responses to stress and pain perception [RGD, Feb 2006].

mRNA and Protein(s)

mRNA Protein Name

NM_017139.1 NP_058835.1 proenkephalin-A precursor

XM_006237835.1 XP_006237897.1 proenkephalin-A isoform X1
Pathways from BioSystems

mRNA	Protein	Name
NM_017139.1	NP_058835.1	proenkephalin-A precursor
XM_006237835.1	XP_006237897.1	proenkephalin-A isoform X1

Homologies

Mus musculus (house mouse)	Penk	NP_001002927.1
Rattus norvegicus (Norway rat)	Penk	NP_058835.1
Danio rerio (zebrafish)	penka	NP_956377.1
Gallus gallus (chicken)	PENK	XP_419213.1
Xenopus tropicalis (tropical clawed frog)	penk	NP_001015744.2
Homo sapiens (human)	PENK	NP_006202.1
Pan troglodytes (chimpanzee)	PENK	XP_001155627.1
	LOC696649	XP_002808525.1
Canis lupus familiaris (dog)	PENK	XP_003640059.2
Bos taurus (cattle)	PENK	NP_776566.1

Gene Ontology
Bibliography

Related articles in PubMed

[Overexpression of PPENK reduces myocardial ischemia reperfusion injury by promoting mitophagy in rats].
Wang Y, Lu X, Zhao P, Jiang J, Yao L
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology33(10)1335-1340(2017 Oct)

Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.
Frederick A, Goldsmith J, de Zavalia N, Amir S
PloS one12(4)e0176279(2017)

Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
Sgroi S, Capper-Loup C, Paganetti P, Kaelin-Lang A
Experimental neurology28080-8(2016 Jun)

Common effects of fat, ethanol, and nicotine on enkephalin in discrete areas of the brain.
Chang GQ, Karatayev O, Barson JR, Liang SC, Leibowitz SF
Neuroscience277665-78(2014 Sep)

Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia.
Poulin JF, Laforest S, Drolet G
Stress (Amsterdam, Netherlands)17(1)88-96(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported.
Title: Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.

The findings of thus study suggest that, in parkinsonian animals treated with l-DOPA, high levels of PPENK are a prerequisite for a locomotor sensitization to l-DOPA treatment
Title: Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.

results suggest that a DeltaFosB-mediated downregulation of enkephalin in the nucleus accumbens might underlie the susceptibility to chronic stress
Title: Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia.

we have demonstrated that ENKergic neurons facilitate unconditioned fear and anxiety through ENK release
Title: Enkephalin knockdown in the central amygdala nucleus reduces unconditioned fear and anxiety.

enkephalin surges and mu opioid stimulation in the same anteromedial dorsal neostriatumregion contribute to signaling the opportunity to eat a sensory reward and to causally generating increased consumption of that reward.
Title: Enkephalin surges in dorsal neostriatum as a signal to eat.

The following Penk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Penk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa28028	XM_006237835.1 Latest version!	Rattus norvegicus proenkephalin (Penk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa12991	NM_017139.1 Latest version!	Rattus norvegicus proenkephalin (Penk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Penk ( XM_006237835.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237897.1 Rattus norvegicus proenkephalin (Penk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28028
Clone ID Related Accession (Same CDS sequence)	XM_006237835.1
Accession Version	XM_006237835.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	proenkephalin-A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTGCTAGCGC TTGGGTCCTG CCTCCTGGCT 
ACAGTGCAGG CAGACTGCAG CCAGGACTGC GCTAAATGCA GCTACCGCCT GGTACGTCCC 
GGCGACATCA ACTTCCTGGC ATGCACACTC GAATGTGAAG GGCAGCTGCC TTCTTTCAAA 
ATCTGGGAGA CCTGCAAGGA TCTCCTGCAG GTGTCCAAGC CCGAGTTCCC TTGGGATAAC 
ATCGACATGT ACAAAGACAG CAGCAAACAG GATGAGAGCC ACTTGCTAGC CAAGAAGTAT 
GGAGGGTTCA TGAAACGGTA TGGAGGCTTC ATGAAGAAGA TGGATGAGCT TTACCCCGTG 
GAGCCAGAAG AAGAGGCCAA TGGAGGCGAG ATCCTTGCCA AGAGGTATGG CGGTTTCATG 
AAGAAGGATG CAGATGAGGG AGACACCTTG GCCAACTCCT CCGACCTGCT GAAAGAGCTA 
CTGGGAACAG GAGACAACCG TGCGAAAGAT AGCCACCAAC AGGAAAGCAC CAACAATGAT 
GAAGACAGCA CGAGCAAGAG GTATGGGGGC TTCATGAGAG GCCTCAAAAG AAGCCCCCAG 
CTGGAAGACG AAGCAAAGGA GCTGCAGAAG CGCTATGGGG GCTTCATGAG AAGGGTCGGG 
CGCCCCGAGT GGTGGATGGA CTATCAGAAG AGATACGGAG GCTTCCTGAA GCGCTTTGCT 
GAGTCTCTAC CCTCGGATGA AGAAGGCGAA AGTTACTCTA AAGAAGTTCC CGAGATGGAA 
AAAAGATACG GAGGCTTTAT GCGGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237897.1
CDS	181..990
Translation	MAQFLRLCIWLLALGSCLLATVQADCSQDCAKCSYRLVRPGDINFLACTLECEGQLPSFKIWETCKDLLQVSKPEFPWDNIDMYKDSSKQDESHLLAKKYGGFMKRYGGFMKKMDELYPVEPEEEANGGEILAKRYGGFMKKDADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDSTSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEGESYSKEVPEMEKRYGGFMRF

Target ORF information:

RefSeq Version	XM_006237835.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proenkephalin (Penk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237835.1

ORF Insert Sequence:

ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTGCTAGCGC TTGGGTCCTG CCTCCTGGCT 
ACAGTGCAGG CAGACTGCAG CCAGGACTGC GCTAAATGCA GCTACCGCCT GGTACGTCCC 
GGCGACATCA ACTTCCTGGC ATGCACACTC GAATGTGAAG GGCAGCTGCC TTCTTTCAAA 
ATCTGGGAGA CCTGCAAGGA TCTCCTGCAG GTGTCCAAGC CCGAGTTCCC TTGGGATAAC 
ATCGACATGT ACAAAGACAG CAGCAAACAG GATGAGAGCC ACTTGCTAGC CAAGAAGTAT 
GGAGGGTTCA TGAAACGGTA TGGAGGCTTC ATGAAGAAGA TGGATGAGCT TTACCCCGTG 
GAGCCAGAAG AAGAGGCCAA TGGAGGCGAG ATCCTTGCCA AGAGGTATGG CGGTTTCATG 
AAGAAGGATG CAGATGAGGG AGACACCTTG GCCAACTCCT CCGACCTGCT GAAAGAGCTA 
CTGGGAACAG GAGACAACCG TGCGAAAGAT AGCCACCAAC AGGAAAGCAC CAACAATGAT 
GAAGACAGCA CGAGCAAGAG GTATGGGGGC TTCATGAGAG GCCTCAAAAG AAGCCCCCAG 
CTGGAAGACG AAGCAAAGGA GCTGCAGAAG CGCTATGGGG GCTTCATGAG AAGGGTCGGG 
CGCCCCGAGT GGTGGATGGA CTATCAGAAG AGATACGGAG GCTTCCTGAA GCGCTTTGCT 
GAGTCTCTAC CCTCGGATGA AGAAGGCGAA AGTTACTCTA AAGAAGTTCC CGAGATGGAA 
AAAAGATACG GAGGCTTTAT GCGGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Penk ( NM_017139.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058835.1 Rattus norvegicus proenkephalin (Penk), mRNA.

Price & Availability↑

CloneID	ORa12991
Clone ID Related Accession (Same CDS sequence)	NM_017139.1
Accession Version	NM_017139.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	proenkephalin-A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y07503.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y07503.1, BC083563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTCGTAGCGC TTGGGTCCTG CCTCCTGGCT 
ACAGTGCAGG CAGACTGCAG CCAGGACTGC GCTAAATGCA GCTACCGCCT GGTACGTCCC 
GGCGACATCA ACTTCCTGGC ATGCACACTC GAATGTGAAG GGCAGCTGCC TTCTTTCAAA 
ATCTGGGAGA CCTGCAAGGA TCTCCTGCAG GTGTCCAAGC CCGAGTTCCC TTGGGATAAC 
ATCGACATGT ACAAAGACAG CAGCAAACAG GATGAGAGCC ACTTGCTAGC CAAGAAGTAT 
GGAGGGTTCA TGAAACGGTA TGGAGGCTTC ATGAAGAAGA TGGATGAGCT TTACCCCGTG 
GAGCCAGAAG AAGAGGCCAA TGGAGGCGAG ATCCTTGCCA AGAGGTATGG CGGTTTCATG 
AAGAAGGATG CAGATGAGGG AGACACCTTG GCCAACTCCT CCGACCTGCT GAAAGAGCTA 
CTGGGAACAG GAGACAACCG TGCGAAAGAT AGCCACCAAC AGGAAAGCAC CAACAATGAT 
GAAGACAGCA CGAGCAAGAG GTATGGGGGC TTCATGAGAG GCCTCAAAAG AAGCCCCCAG 
CTGGAAGACG AAGCAAAGGA GCTGCAGAAG CGCTATGGGG GCTTCATGAG AAGGGTCGGG 
CGCCCCGAGT GGTGGATGGA CTATCAGAAG AGATACGGAG GCTTCCTGAA GCGCTTTGCT 
GAGTCTCTAC CCTCGGATGA AGAAGGCGAA AGTTACTCTA AAGAAGTTCC CGAGATGGAA 
AAAAGATACG GAGGCTTTAT GCGGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058835.1
CDS	328..1137
Translation	MAQFLRLCIWLVALGSCLLATVQADCSQDCAKCSYRLVRPGDINFLACTLECEGQLPSFKIWETCKDLLQVSKPEFPWDNIDMYKDSSKQDESHLLAKKYGGFMKRYGGFMKKMDELYPVEPEEEANGGEILAKRYGGFMKKDADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDSTSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEGESYSKEVPEMEKRYGGFMRF

Target ORF information:

RefSeq Version	NM_017139.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proenkephalin (Penk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017139.1

ORF Insert Sequence:

ATGGCGCAGT TCCTGAGACT TTGCATCTGG CTCGTAGCGC TTGGGTCCTG CCTCCTGGCT 
ACAGTGCAGG CAGACTGCAG CCAGGACTGC GCTAAATGCA GCTACCGCCT GGTACGTCCC 
GGCGACATCA ACTTCCTGGC ATGCACACTC GAATGTGAAG GGCAGCTGCC TTCTTTCAAA 
ATCTGGGAGA CCTGCAAGGA TCTCCTGCAG GTGTCCAAGC CCGAGTTCCC TTGGGATAAC 
ATCGACATGT ACAAAGACAG CAGCAAACAG GATGAGAGCC ACTTGCTAGC CAAGAAGTAT 
GGAGGGTTCA TGAAACGGTA TGGAGGCTTC ATGAAGAAGA TGGATGAGCT TTACCCCGTG 
GAGCCAGAAG AAGAGGCCAA TGGAGGCGAG ATCCTTGCCA AGAGGTATGG CGGTTTCATG 
AAGAAGGATG CAGATGAGGG AGACACCTTG GCCAACTCCT CCGACCTGCT GAAAGAGCTA 
CTGGGAACAG GAGACAACCG TGCGAAAGAT AGCCACCAAC AGGAAAGCAC CAACAATGAT 
GAAGACAGCA CGAGCAAGAG GTATGGGGGC TTCATGAGAG GCCTCAAAAG AAGCCCCCAG 
CTGGAAGACG AAGCAAAGGA GCTGCAGAAG CGCTATGGGG GCTTCATGAG AAGGGTCGGG 
CGCCCCGAGT GGTGGATGGA CTATCAGAAG AGATACGGAG GCTTCCTGAA GCGCTTTGCT 
GAGTCTCTAC CCTCGGATGA AGAAGGCGAA AGTTACTCTA AAGAAGTTCC CGAGATGGAA 
AAAAGATACG GAGGCTTTAT GCGGTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Overexpression of PPENK reduces myocardial ischemia reperfusion injury by promoting mitophagy in rats].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology33(10)1335-1340(2017 Oct)
Wang Y,Lu X,Zhao P,Jiang J,Yao L

Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.
PloS one12(4)e0176279(2017)
Frederick A,Goldsmith J,de Zavalia N,Amir S

Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
Experimental neurology28080-8(2016 Jun)
Sgroi S,Capper-Loup C,Paganetti P,Kaelin-Lang A

Common effects of fat, ethanol, and nicotine on enkephalin in discrete areas of the brain.
Neuroscience277665-78(2014 Sep)
Chang GQ,Karatayev O,Barson JR,Liang SC,Leibowitz SF

Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia.
Stress (Amsterdam, Netherlands)17(1)88-96(2014 Jan)
Poulin JF,Laforest S,Drolet G

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Penk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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