Gene Symbol | Psenen |
Entrez Gene ID | 292788 |
Full Name | presenilin enhancer gamma secretase subunit |
Synonyms | RGD1312037 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Psenen cDNA ORF clone
gRNAs
Gene Symbol | Psenen |
Entrez Gene ID | 292788 |
Full Name | presenilin enhancer gamma secretase subunit |
Synonyms | RGD1312037 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006228770.3 | XP_006228832.1 | gamma-secretase subunit PEN-2 isoform X1 |
NM_001008764.2 | NP_001008764.1 | gamma-secretase subunit PEN-2 |
Homo sapiens (human) | PSENEN | NP_001268461.1 |
PSENEN | XP_002801231.1 | |
Drosophila melanogaster (fruit fly) | pen-2 | NP_788401.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008094 | XP_317362.2 |
Xenopus tropicalis (tropical clawed frog) | psenen | NP_001016336.1 |
Pan troglodytes (chimpanzee) | PSENEN | XP_512600.1 |
Mus musculus (house mouse) | Psenen | NP_079774.1 |
Canis lupus familiaris (dog) | PSENEN | XP_533689.1 |
Bos taurus (cattle) | PSENEN | NP_001008669.1 |
Rattus norvegicus (Norway rat) | Psenen | NP_001008764.1 |
Danio rerio (zebrafish) | psenen | NP_991139.1 |
Caenorhabditis elegans (roundworm) | pen-2 | NP_499459.1 |
An atomic structure of human ?-secretase.
Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SHW, Shi Y
Nature525(7568)212-217(2015 Sep)
Three-dimensional structure of human ?-secretase.
Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SHW, Shi Y
Nature512(7513)166-170(2014 Aug)
Inhibition of gamma-secretase activity promotes differentiation of embryonic pancreatic precursor cells into functional islet-like clusters in poly(ethylene glycol) hydrogel culture.
Mason MN, Mahoney MJ
Tissue engineering. Part A16(8)2593-603(2010 Aug)
gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.
Fr?nberg J, Karlstr?m H, Winblad B, Tjernberg LO, Frykman S
PloS one5(3)e9772(2010 Mar)
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.
Zhao G, Liu Z, Ilagan MX, Kopan R
The Journal of neuroscience : the official journal of the Society for Neuroscience30(5)1648-56(2010 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results indicate that concerted differentiation of pancreatic precursor cell aggregates into functionally mature islet-like clusters can be achieved in poly(ethylene glycol)-based hydrogel cultures.
Title: Inhibition of gamma-secretase activity promotes differentiation of embryonic pancreatic precursor cells into functional islet-like clusters in poly(ethylene glycol) hydrogel culture.
analysis of gamma-secretase cleavage of five substrates, APP, Notch1, N-cadherin, ephrinB and p75 neurotrophin receptor (p75-NTR) in membranes isolated from embryonic, young or old adult rat brains
Title: gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.
Nicastrin, presenilin 1, APH-1, and PEN-2 form an active gamma-secretase complex expressed in mitochondria.
Title: Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
The following Psenen gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psenen cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa11246 | |
Clone ID Related Accession (Same CDS sequence) | XM_006228770.3 , NM_001008764.2 | |
Accession Version | NM_001008764.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-08-03 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | gamma-secretase subunit PEN-2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100104.1. On Aug 7, 2005 this sequence version replaced NM_001008764.1. ##Evidence-Data-START## Transcript exon combination :: BC100104.1, CO565158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906349 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAACTTAG AGCGGGTGTC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001008764.1 |
CDS | 110..415 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACTTAG AGCGGGTGTC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa11246 | |
Clone ID Related Accession (Same CDS sequence) | XM_006228770.3 , NM_001008764.2 | |
Accession Version | XM_006228770.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | gamma-secretase subunit PEN-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228770.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTTAG AGCGGGTGTC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006228832.1 |
CDS | 166..471 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACTTAG AGCGGGTGTC CAATGAGGAG AAGTTGAACC TGTGCCGGAA GTACTATCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
An atomic structure of human ?-secretase. |
Three-dimensional structure of human ?-secretase. |
Inhibition of gamma-secretase activity promotes differentiation of embryonic pancreatic precursor cells into functional islet-like clusters in poly(ethylene glycol) hydrogel culture. |
gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes. |
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. |