Ftl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ftl1
Entrez Gene ID	29292
Full Name	ferritin light chain 1
Synonyms	Ftl
General protein information	Preferred Names ferritin light chain 1 Names ferritin light chain 1 ferritin L subunit 1 ferritin, light polypeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	iron-storage protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022500.4	NP_071945.3	ferritin light chain 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FTL	XP_001155938.2
	FTL	XP_002801381.1
Canis lupus familiaris (dog)	LOC102155200	XP_005634393.1
Bos taurus (cattle)	LOC788801	XP_003587783.2
Rattus norvegicus (Norway rat)	RGD1566189	XP_574537.1
Rattus norvegicus (Norway rat)	LOC100360087	XP_002729599.1
Rattus norvegicus (Norway rat)	LOC100363177	XP_002729061.1
Xenopus tropicalis (tropical clawed frog)	MGC75752	NP_989212.1
Canis lupus familiaris (dog)	FTL	NP_001019807.1
Rattus norvegicus (Norway rat)	Ftl1l1	XP_577041.1
	LOC100427851	XP_002802741.1
Bos taurus (cattle)	LOC783224	XP_002685102.3
Rattus norvegicus (Norway rat)	Ftl1	NP_071945.3
Bos taurus (cattle)	FTL	NP_777217.1
Mus musculus (house mouse)	Gm20746	XP_003688927.2
Rattus norvegicus (Norway rat)	LOC100359668	XP_002729671.1
Homo sapiens (human)	FTL	NP_000137.2
	LOC718777	XP_002799272.1
Bos taurus (cattle)	LOC101904953	XP_005208358.1
Mus musculus (house mouse)	Ftl1	NP_034370.2
Rattus norvegicus (Norway rat)	LOC100362384	XP_002728087.1
Rattus norvegicus (Norway rat)	RGD1560687	XP_576192.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO
Nature cell biology16(11)1069-79(2014 Nov)

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration.
Finazzi D, Arosio P
Archives of toxicology88(10)1787-802(2014 Oct)

Differential regulation of ferritin subunits and iron transport proteins: an effect of targeted hepatic X-irradiation.
Naz N, Ahmad S, Cameron S, Moriconi F, Rave-Fr?nk M, Christiansen H, Hess CF, Ramadori G, Malik IA
BioMed research international2013353106(2013)

A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation.
Adams LD, Lemire JM, Schwartz SM
Arteriosclerosis, thrombosis, and vascular biology19(11)2600-8(1999 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FTL can be used as a serum marker for early phase radiation-induced liver damage.
Title: Differential regulation of ferritin subunits and iron transport proteins: an effect of targeted hepatic X-irradiation.

Data suggest that soluble transferrin receptor (sTfR) indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training.
Title: The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise.

Up-regulation of the expression of Ft-L could represent a protective response to the increased oxidative stress in the aging myocardium.
Title: Iron, ferritin and proteins of the methionine-centered redox cycle in young and old rat hearts.

Ftl expression in rat hepatocytes and Kupffer cells after lead nitrate treatment is reported.
Title: Ferritin expression in rat hepatocytes and Kupffer cells after lead nitrate treatment.

The following Ftl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ftl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05775	NM_022500.4 Latest version!	Rattus norvegicus ferritin light chain 1 (Ftl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ftl1 ( NM_022500.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071945.3 Rattus norvegicus ferritin light chain 1 (Ftl1), mRNA.

Price & Availability↑

CloneID	ORa05775
Clone ID Related Accession (Same CDS sequence)	NM_022500.4
Accession Version	NM_022500.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	ferritin light chain 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061525.1. On Aug 31, 2012 this sequence version replaced NM_022500.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061525.1, FQ211261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGACCTCTC AGATTCGTCA GAATTATTCC ACCGAAGTGG AAGCTGCCGT GAACCGCCTG 
GTCAACTTGC ACCTGCGGGC CTCTTACACC TACCTCTCTC TGGGCTTCTT TTTTGATCGG 
GATGACGTGG CTTTGGAAGG CGTAGGCCAC TTCTTCCGCG AATTGGCCGA GGAGAAGCGC 
GAGGGCGCCG AGCGTCTCCT CAAGTTGCAG AACGAACGCG GGGGCCGTGC ACTCTTCCAG 
GATGTGCAGA AGCCATCTCA AGATGAGTGG GGTAAAACCC TGGAGGCCAT GGAAGCTGCC 
TTGGCCCTGG AGAAGAACCT GAACCAGGCC CTCTTGGATC TGCACGCCCT GGGCTCTGCC 
CGCACAGACC CTCACCTCTG TGACTTCTTG GAAAGCCACT TCCTGGATAA GGAGGTGAAG 
CTCATCAAGA AGATGGGCAA CCACCTGACC AACCTCCGTA GGGTGGCAGG GCCACAACCA 
GCGCAGACTG GCGTGGCCCA GGCATCTCTG GGCGAGTATC TCTTTGAGCG CCTCACTCTG 
AAGCACGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071945.3
CDS	206..757
Translation	MTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFFFDRDDVALEGVGHFFRELAEEKREGAERLLKLQNERGGRALFQDVQKPSQDEWGKTLEAMEAALALEKNLNQALLDLHALGSARTDPHLCDFLESHFLDKEVKLIKKMGNHLTNLRRVAGPQPAQTGVAQASLGEYLFERLTLKHD

Target ORF information:

RefSeq Version	NM_022500.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ferritin light chain 1 (Ftl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022500.4

ORF Insert Sequence:

ATGACCTCTC AGATTCGTCA GAATTATTCC ACCGAAGTGG AAGCTGCCGT GAACCGCCTG 
GTCAACTTGC ACCTGCGGGC CTCTTACACC TACCTCTCTC TGGGCTTCTT TTTTGATCGG 
GATGACGTGG CTTTGGAAGG CGTAGGCCAC TTCTTCCGCG AATTGGCCGA GGAGAAGCGC 
GAGGGCGCCG AGCGTCTCCT CAAGTTGCAG AACGAACGCG GGGGCCGTGC ACTCTTCCAG 
GATGTGCAGA AGCCATCTCA AGATGAGTGG GGTAAAACCC TGGAGGCCAT GGAAGCTGCC 
TTGGCCCTGG AGAAGAACCT GAACCAGGCC CTCTTGGATC TGCACGCCCT GGGCTCTGCC 
CGCACAGACC CTCACCTCTG TGACTTCTTG GAAAGCCACT TCCTGGATAA GGAGGTGAAG 
CTCATCAAGA AGATGGGCAA CCACCTGACC AACCTCCGTA GGGTGGCAGG GCCACAACCA 
GCGCAGACTG GCGTGGCCCA GGCATCTCTG GGCGAGTATC TCTTTGAGCG CCTCACTCTG 
AAGCACGACT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nature cell biology16(11)1069-79(2014 Nov)
Dowdle WE,Nyfeler B,Nagel J,Elling RA,Liu S,Triantafellow E,Menon S,Wang Z,Honda A,Pardee G,Cantwell J,Luu C,Cornella-Taracido I,Harrington E,Fekkes P,Lei H,Fang Q,Digan ME,Burdick D,Powers AF,Helliwell SB,D'Aquin S,Bastien J,Wang H,Wiederschain D,Kuerth J,Bergman P,Schwalb D,Thomas J,Ugwonali S,Harbinski F,Tallarico J,Wilson CJ,Myer VE,Porter JA,Bussiere DE,Finan PM,Labow MA,Mao X,Hamann LG,Manning BD,Valdez RA,Nicholson T,Schirle M,Knapp MS,Keaney EP,Murphy LO

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration.
Archives of toxicology88(10)1787-802(2014 Oct)
Finazzi D,Arosio P

Differential regulation of ferritin subunits and iron transport proteins: an effect of targeted hepatic X-irradiation.
BioMed research international2013353106(2013)
Naz N,Ahmad S,Cameron S,Moriconi F,Rave-Fr?nk M,Christiansen H,Hess CF,Ramadori G,Malik IA

A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation.
Arteriosclerosis, thrombosis, and vascular biology19(11)2600-8(1999 Nov)
Adams LD,Lemire JM,Schwartz SM