Gene Symbol | Prcp |
Entrez Gene ID | 293118 |
Full Name | prolylcarboxypeptidase |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Prcp cDNA ORF clone
gRNAs
Gene Symbol | Prcp |
Entrez Gene ID | 293118 |
Full Name | prolylcarboxypeptidase |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001106281.2 | NP_001099751.2 | lysosomal Pro-X carboxypeptidase precursor |
Pan troglodytes (chimpanzee) | PRCP | XP_001175153.1 |
PRCP | XP_001096750.1 | |
Mus musculus (house mouse) | Prcp | NP_082519.1 |
Rattus norvegicus (Norway rat) | Prcp | NP_001099751.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000994 | XP_309189.4 |
Oryza sativa (rice) | Os01g0767100 | NP_001044360.1 |
Xenopus tropicalis (tropical clawed frog) | prcp | NP_001072639.1 |
Canis lupus familiaris (dog) | PRCP | XP_533994.2 |
Danio rerio (zebrafish) | prcp | NP_001002694.1 |
Homo sapiens (human) | PRCP | NP_005031.1 |
Bos taurus (cattle) | PRCP | NP_001033253.1 |
Gallus gallus (chicken) | PRCP | XP_425654.3 |
Drosophila melanogaster (fruit fly) | CG2493 | NP_610037.1 |
Caenorhabditis elegans (roundworm) | pcp-5 | NP_498718.1 |
Arabidopsis thaliana (thale cress) | AT5G65760 | NP_201377.2 |
Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats.
Liu J, Hakucho A, Fujimiya T
BioMed research international2015409350(2015)
Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR).
Marangoni RA, Santos RA, Piccolo C
Peptides6169-74(2014 Nov)
Relationship of angiotensinase and vasopressinase activities between hypothalamus, heart, and plasma in L-NAME-treated WKY and SHR.
Villarejo AB, Prieto I, Segarra AB, Banegas I, Wangensteen R, Vives F, de Gasparo M, Ram?rez-S?nchez M
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme46(8)561-7(2014 Jul)
Prolylcarboxypeptidase promotes angiogenesis and vascular repair.
Adams GN, Stavrou EX, Fang C, Merkulova A, Alaiti MA, Nakajima K, Morooka T, Merkulov S, Larusch GA, Simon DI, Jain MK, Schmaier AH
Blood122(8)1522-31(2013 Aug)
Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.
Jeong JK, Szabo G, Raso GM, Meli R, Diano S
American journal of physiology. Endocrinology and metabolism302(12)E1502-10(2012 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
chronic ethanol regimen is sufficient to promote the enhanced RAS activity-induced decrease in the production of cardiac collagen via downregulated angiotensinase C, leading to the further deterioration of LV systolic dysfunction in SHRs
Title: Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats.
it appears unlikely that PRCP function is regulated by the renin-angiotensin system or by afterload conditions.
Title: Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR).
eNOS inhibition in spontaneously hypertensive rats induces or enhances an inverse reciprocal interaction between hypothalamus and left ventricle involving the renin-angiotensin system and vasopressin.
Title: Relationship of angiotensinase and vasopressinase activities between hypothalamus, heart, and plasma in L-NAME-treated WKY and SHR.
PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.
Title: Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents.
Suggest that in renovascular hypertension the repression of increases in systolic blood pressure and reversal of mesenteric artery remodelling by rutaecarpine may be related to increased expression of PRCP.
Title: Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats.
The following Prcp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prcp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa04541 | |
Clone ID Related Accession (Same CDS sequence) | NM_001106281.2 | |
Accession Version | NM_001106281.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-27 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | lysosomal Pro-X carboxypeptidase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07004794.1 and AABR07004795.1. On Jan 24, 2008 this sequence version replaced NM_001106281.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCTGCT GGGCTCTCCT GCTCCTGCCT TTTCTATCAC TCGGGGCCGC CACAACCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001099751.2 |
CDS | 63..1544 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGGCTGCT GGGCTCTCCT GCTCCTGCCT TTTCTATCAC TCGGGGCCGC CACAACCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats. |
Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR). |
Relationship of angiotensinase and vasopressinase activities between hypothalamus, heart, and plasma in L-NAME-treated WKY and SHR. |
Prolylcarboxypeptidase promotes angiogenesis and vascular repair. |
Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity. |