Folr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Folr2
Entrez Gene ID	293154
Full Name	folate receptor beta
General protein information	Preferred Names folate receptor beta Names folate receptor beta folate receptor 2 (fetal)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32

mRNA and Protein(s)

mRNA	Protein	Name
XM_006229858.3	XP_006229920.1	folate receptor beta isoform X1
XM_017588961.1	XP_017444450.1	folate receptor beta isoform X1
XM_008759703.2	XP_008757925.1	folate receptor beta isoform X1
NM_001106283.1	NP_001099753.1	folate receptor beta precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FOLR2	XP_003313302.2
Bos taurus (cattle)	FOLR2	NP_001068793.1
Rattus norvegicus (Norway rat)	Folr2	NP_001099753.1
	FOLR2	XP_001114686.1
Mus musculus (house mouse)	Folr2	NP_032061.1
Homo sapiens (human)	FOLR2	NP_000794.3
Canis lupus familiaris (dog)	FOLR2	XP_005633610.1

Gene Ontology
Bibliography

Related articles in PubMed

Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus.
Lu Y, Parker N, Kleindl PJ, Cross VA, Wollak K, Westrick E, Stinnette TW, Gehrke MA, Wang K, Santhapuram HK, You F, Hahn SJ, Vaughn JF, Klein PJ, Vlahov IR, Low PS, Leamon CP
Molecular medicine (Cambridge, Mass.)21584-96(2015 Jul)

Folate receptor-? constitutes a marker for human proinflammatory monocytes.
Shen J, Hilgenbrink AR, Xia W, Feng Y, Dimitrov DS, Lockwood MB, Amato RJ, Low PS
Journal of leukocyte biology96(4)563-70(2014 Oct)

Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Watkins D, Rosenblatt DS
Journal of inherited metabolic disease35(4)665-70(2012 Jul)

Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients.
van der Heijden JW, Oerlemans R, Dijkmans BA, Qi H, van der Laken CJ, Lems WF, Jackman AL, Kraan MC, Tak PP, Ratnam M, Jansen G
Arthritis and rheumatism60(1)12-21(2009 Jan)

Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene.
Page ST, Owen WC, Price K, Elwood PC
Journal of molecular biology229(4)1175-83(1993 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EC0565 forms micellar aggregates in physiological buffers and demonstrates good water solubility as well as strong multivalent FR-binding capacity. EC0565 inhibited mTOR signaling in rat macrophages at nanomolar concentrations
Title: Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus.

The following Folr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Folr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00690	NM_001106283.1 Latest version!	Rattus norvegicus folate receptor beta (Folr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00690	XM_017588961.1 Latest version!	Rattus norvegicus folate receptor beta (Folr2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00690	XM_006229858.3 Latest version!	Rattus norvegicus folate receptor beta (Folr2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa00690	XM_008759703.2 Latest version!	Rattus norvegicus folate receptor beta (Folr2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Folr2 ( NM_001106283.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099753.1 Rattus norvegicus folate receptor beta (Folr2), mRNA.

Price & Availability↑

CloneID	ORa00690
Clone ID Related Accession (Same CDS sequence)	XM_006229858.3 , XM_017588961.1 , XM_008759703.2 , NM_001106283.1
Accession Version	NM_001106283.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	folate receptor beta precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473956.2. On or before Oct 4, 2007 this sequence version replaced XM_001067815.1, XM_215013.4. ##Evidence-Data-START## CDS exon combination :: FQ211323.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMN01906349 [ECO:0000350] ##Evidence-Data-END##

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099753.1
CDS	274..1032
Translation	MAWKQTPLLLLVYMITTCSARDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKRNACCSVNTSQELHKDNSRLYNFNWDHCGEMTPACKRHFIQDACLYECSPNLGPWIQQAGQSWRKERFLDVPLCKEDCQEWWEACRTSFTCKRDWHKGWDWTSGINKCPDTAPCRTFQYYFPTPASLCEGLWSHSYKVSNYSRGSGQCIQMWFDSTQGNPNEEVVKFYASFMTSGTVYHAAILLVPSLAPVLSLWLPD

Target ORF information:

RefSeq Version	NM_001106283.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus folate receptor beta (Folr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106283.1

ORF Insert Sequence:

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Folr2 ( XM_006229858.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229920.1 Rattus norvegicus folate receptor beta (Folr2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa00690
Clone ID Related Accession (Same CDS sequence)	XM_006229858.3 , XM_017588961.1 , XM_008759703.2 , NM_001106283.1
Accession Version	XM_006229858.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	folate receptor beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229858.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229920.1
CDS	148..906
Translation	MAWKQTPLLLLVYMITTCSARDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKRNACCSVNTSQELHKDNSRLYNFNWDHCGEMTPACKRHFIQDACLYECSPNLGPWIQQAGQSWRKERFLDVPLCKEDCQEWWEACRTSFTCKRDWHKGWDWTSGINKCPDTAPCRTFQYYFPTPASLCEGLWSHSYKVSNYSRGSGQCIQMWFDSTQGNPNEEVVKFYASFMTSGTVYHAAILLVPSLAPVLSLWLPD

Target ORF information:

RefSeq Version	XM_006229858.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus folate receptor beta (Folr2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229858.3

ORF Insert Sequence:

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Folr2 ( XM_017588961.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444450.1 Rattus norvegicus folate receptor beta (Folr2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa00690
Clone ID Related Accession (Same CDS sequence)	XM_006229858.3 , XM_017588961.1 , XM_008759703.2 , NM_001106283.1
Accession Version	XM_017588961.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	folate receptor beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444450.1
CDS	720..1478
Translation	MAWKQTPLLLLVYMITTCSARDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKRNACCSVNTSQELHKDNSRLYNFNWDHCGEMTPACKRHFIQDACLYECSPNLGPWIQQAGQSWRKERFLDVPLCKEDCQEWWEACRTSFTCKRDWHKGWDWTSGINKCPDTAPCRTFQYYFPTPASLCEGLWSHSYKVSNYSRGSGQCIQMWFDSTQGNPNEEVVKFYASFMTSGTVYHAAILLVPSLAPVLSLWLPD

Target ORF information:

RefSeq Version	XM_017588961.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus folate receptor beta (Folr2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017588961.1

ORF Insert Sequence:

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Folr2 ( XM_008759703.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757925.1 Rattus norvegicus folate receptor beta (Folr2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa00690
Clone ID Related Accession (Same CDS sequence)	XM_006229858.3 , XM_017588961.1 , XM_008759703.2 , NM_001106283.1
Accession Version	XM_008759703.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	folate receptor beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759703.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757925.1
CDS	184..942
Translation	MAWKQTPLLLLVYMITTCSARDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKRNACCSVNTSQELHKDNSRLYNFNWDHCGEMTPACKRHFIQDACLYECSPNLGPWIQQAGQSWRKERFLDVPLCKEDCQEWWEACRTSFTCKRDWHKGWDWTSGINKCPDTAPCRTFQYYFPTPASLCEGLWSHSYKVSNYSRGSGQCIQMWFDSTQGNPNEEVVKFYASFMTSGTVYHAAILLVPSLAPVLSLWLPD

Target ORF information:

RefSeq Version	XM_008759703.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus folate receptor beta (Folr2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759703.2

ORF Insert Sequence:

ATGGCCTGGA AACAGACACC ACTCCTGCTT TTGGTCTACA TGATCACAAC ATGCAGTGCC 
CGGGACAGAA CAGACCTGCT CAACGTTTGC ATGGATGCCA AGCACCATAA GACAAAGCCA 
GGCCCGGAGG ACAAGCTGCA TGACCAGTGT AGTCCATGGA AGAGAAATGC CTGCTGCTCA 
GTCAACACCA GCCAGGAGCT ACACAAGGAC AACTCCCGTC TGTACAATTT CAATTGGGAT 
CACTGTGGTG AGATGACGCC CGCCTGTAAG CGTCACTTCA TCCAAGACGC CTGCCTGTAT 
GAGTGTTCCC CCAATCTTGG GCCTTGGATT CAGCAGGCAG GCCAGAGCTG GCGCAAAGAG 
CGCTTCCTGG ATGTGCCCTT ATGCAAAGAG GACTGTCAGG AGTGGTGGGA AGCCTGTCGT 
ACCTCCTTTA CCTGCAAGAG AGACTGGCAT AAAGGCTGGG ACTGGACCTC AGGCATTAAC 
AAGTGCCCAG ACACAGCACC CTGCCGCACA TTTCAGTACT ATTTCCCGAC ACCAGCCAGC 
CTTTGTGAGG GTCTCTGGAG TCACTCCTAC AAGGTCAGCA ACTATAGCAG AGGGAGTGGC 
CAGTGCATCC AGATGTGGTT TGACTCAACC CAGGGCAATC CCAATGAGGA AGTGGTGAAG 
TTCTATGCTT CCTTTATGAC ATCTGGGACT GTGTACCATG CAGCAATACT TCTTGTGCCC 
AGCCTGGCCC CAGTGCTGTC ATTATGGCTC CCTGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus.
Molecular medicine (Cambridge, Mass.)21584-96(2015 Jul)
Lu Y,Parker N,Kleindl PJ,Cross VA,Wollak K,Westrick E,Stinnette TW,Gehrke MA,Wang K,Santhapuram HK,You F,Hahn SJ,Vaughn JF,Klein PJ,Vlahov IR,Low PS,Leamon CP

Folate receptor-? constitutes a marker for human proinflammatory monocytes.
Journal of leukocyte biology96(4)563-70(2014 Oct)
Shen J,Hilgenbrink AR,Xia W,Feng Y,Dimitrov DS,Lockwood MB,Amato RJ,Low PS

Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Journal of inherited metabolic disease35(4)665-70(2012 Jul)
Watkins D,Rosenblatt DS

Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients.
Arthritis and rheumatism60(1)12-21(2009 Jan)
van der Heijden JW,Oerlemans R,Dijkmans BA,Qi H,van der Laken CJ,Lems WF,Jackman AL,Kraan MC,Tak PP,Ratnam M,Jansen G

Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene.
Journal of molecular biology229(4)1175-83(1993 Feb)
Page ST,Owen WC,Price K,Elwood PC

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Folr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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