Gene Symbol | Dkk1 |
Entrez Gene ID | 293897 |
Full Name | dickkopf WNT signaling pathway inhibitor 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Dkk1 cDNA ORF clone
Gene Symbol | Dkk1 |
Entrez Gene ID | 293897 |
Full Name | dickkopf WNT signaling pathway inhibitor 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001106350.1 | NP_001099820.1 | dickkopf-related protein 1 precursor |
Rattus norvegicus (Norway rat) | Dkk1 | NP_001099820.1 |
Xenopus tropicalis (tropical clawed frog) | dkk1 | NP_001016283.1 |
Homo sapiens (human) | DKK1 | NP_036374.1 |
Danio rerio (zebrafish) | dkk1b | NP_571078.1 |
DKK1 | XP_001098844.1 | |
Bos taurus (cattle) | DKK1 | NP_001192473.1 |
Mus musculus (house mouse) | Dkk1 | NP_034181.2 |
Rattus norvegicus (Norway rat) | LOC100912050 | XP_003749137.1 |
Pan troglodytes (chimpanzee) | DKK1 | NP_001248771.1 |
Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model.
Zhang Y, Wang S, Zheng Y, Liu A
The Journal of laryngology and otology131(10)860-865(2017 Oct)
EZH2-mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis.
Yang Y, Chen XX, Li WX, Wu XQ, Huang C, Xie J, Zhao YX, Meng XM, Li J
Journal of cellular and molecular medicine21(10)2317-2328(2017 Oct)
Increased Dickkopf-1 expression is correlated with poisoning severity in carbon monoxide-poisoned humans and rats.
Pang L, Dong N, Wang D, Zhang N, Xing J
Inhalation toxicology28(10)455-62(2016 08)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results provide evidence that DKK1 protein is involved in the pathogenesis of tympanosclerosis by regulating the Wnt/beta-catenin signalling pathway.
Title: Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model.
The severity of acute CO poisoning in rat models is associated with elevated serum DKK-1 levels and its upregulation in the brain tissue.
Title: Increased Dickkopf-1 expression is correlated with poisoning severity in carbon monoxide-poisoned humans and rats.
DKK-1 secreted by PMSCs played a vital role in controlling the Wnt/beta-catenin signaling pathway in breast cancer.
Title: Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/?-catenin signaling pathway.
platelet-derived Dickkopf-1 (Dkk1) as the major Wnt antagonist contributing to the suppression of Wnt/beta-catenin signaling in AECs during acute lung inflammation.
Title: Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute lung inflammation.
Induction of Dickkopf-1 contributes to methyl-4-phenylpyridinium-induced neurotoxicity via inhibition of the canonical Wnt pathway.
Title: Induction of Dickkopf-1 contributes to the neurotoxicity of MPP+ in PC12 cells via inhibition of the canonical Wnt signaling pathway.
The following Dkk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dkk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa01068 | |
Clone ID Related Accession (Same CDS sequence) | NM_001106350.1 | |
Accession Version | NM_001106350.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-15 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | dickkopf-related protein 1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473953.1. On or before Oct 4, 2007 this sequence version replaced XM_219804.4, XM_001079710.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGACGGTTG TGCGTGCAGT GGCAGCTGTC CGGTTCTTGG TCGTGCTTTC AACGATGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001099820.1 |
CDS | 134..946 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001106350.1 |
1 | ATGACGGTTG TGCGTGCAGT GGCAGCTGTC CGGTTCTTGG TCGTGCTTTC AACGATGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model. |
EZH2-mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis. |
Increased Dickkopf-1 expression is correlated with poisoning severity in carbon monoxide-poisoned humans and rats. |