Glo1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Glo1 |
| Entrez Gene ID | 294320 |
| Full Name | glyoxalase 1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | predicted to have lactoylglutathione lyase activity [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_207594.2 | NP_997477.1 | lactoylglutathione lyase |
| GLO1 | XP_001117098.1 | |
| Canis lupus familiaris (dog) | GLO1 | XP_532129.3 |
| Homo sapiens (human) | GLO1 | NP_006699.2 |
| Bos taurus (cattle) | LOC101905254 | XP_005208451.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012071 | XP_320453.4 |
| Eremothecium gossypii | AGOS_ADR286C | NP_984382.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_11543 | XP_003718417.1 |
| Arabidopsis thaliana (thale cress) | AT1G08110 | NP_001030995.1 |
| Oryza sativa (rice) | Os05g0295800 | NP_001055113.1 |
| Bos taurus (cattle) | GLO1 | NP_001076965.1 |
| Drosophila melanogaster (fruit fly) | CG1707 | NP_610270.1 |
| Saccharomyces cerevisiae (baker's yeast) | GLO1 | NP_013710.1 |
| Kluyveromyces lactis | KLLA0F06226g | XP_455362.1 |
| Neurospora crassa | NCU04815 | XP_960441.1 |
| Mus musculus (house mouse) | Glo1 | NP_079650.3 |
| Rattus norvegicus (Norway rat) | Glo1 | NP_997477.1 |
| Danio rerio (zebrafish) | glo1 | NP_998316.1 |
| Pan troglodytes (chimpanzee) | GLO1 | XP_001173775.1 |
| Gallus gallus (chicken) | GLO1 | XP_419481.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012072 | XP_320454.4 |
| Schizosaccharomyces pombe (fission yeast) | glo1 | NP_596010.1 |
| Xenopus tropicalis (tropical clawed frog) | glo1 | NP_001025545.1 |
Related articles in PubMed
Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts.
Stratmann B, Goldstein B, Thornalley PJ, Rabbani N, Tschoepe D
International journal of molecular sciences18(3)(2017 Feb)
Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis.
Hollenbach M, Thonig A, Pohl S, Ripoll C, Michel M, Zipprich A
PloS one12(2)e0171260(2017)
Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model.
Brouwers O, Yu L, Niessen P, Slenter J, Jaspers K, Wagenaar A, Post M, Miyata T, Backes W, Stehouwer C, Huijberts M, Schalkwijk C
Glycoconjugate journal33(4)627-30(2016 Aug)
Temporal dynamics of glyoxalase 1 in secondary neuronal injury.
Pieroh P, Koch M, Wagner DC, Boltze J, Ehrlich A, Ghadban C, Hobusch C, Birkenmeier G, Dehghani F
PloS one9(2)e87364(2014)
Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts.
Engelbrecht B, Stratmann B, Hess C, Tschoepe D, Gawlowski T
PloS one8(5)e65195(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Increased biosynthesis of collagens 1 and 4 was detected at mRNA and protein level following knockdown of glyoxalase 1 in L6 myoblasts.
Title: Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts.
These results show the importance of Glo-I as major detoxifying enzyme for methylglyoxal in cirrhosis. The reduced expression of Glo-I in cirrhosis demonstrates a possible explanation for increased inflammatory injury and suggests a "vicious circle" in liver disease.
Title: Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis.
Diabetes-induced impairment of arteriogenic adaptation can be partially rescued by overexpressing of GLO-I, indicating a role of AGEs in diabetes-induced impaired collateral formation
Title: Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model.
Data suggest that the high dynamics of glyoxalase 1 expression and distribution following neuronal injury may indicate a role of Glyoxalase 1.
Title: Temporal dynamics of glyoxalase 1 in secondary neuronal injury.
GLO1 knock down augmented GLUT4 level on the cell surface of L6 myoblasts at least in part through reduction of GLUT4 internalization.
Title: Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts.
The following Glo1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Glo1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa05577 | |
| Clone ID Related Accession (Same CDS sequence) | NM_207594.2 | |
| Accession Version | NM_207594.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | lactoylglutathione lyase | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061570.1. On Aug 31, 2012 this sequence version replaced NM_207594.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061570.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906347 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCAGAGC CACAGCCAGC GTCCAGTGGT CTTACTGATG AGGCCGCCCT CAGTTGCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_997477.1 |
| CDS | 78..632 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_207594.2 |
ORF Insert Sequence:
1 | ATGGCAGAGC CACAGCCAGC GTCCAGTGGT CTTACTGATG AGGCCGCCCT CAGTTGCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts. |
|
Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis. |
|
Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model. |
|
Temporal dynamics of glyoxalase 1 in secondary neuronal injury. |
|
Impact of GLO1 knock down on GLUT4 trafficking and glucose uptake in L6 myoblasts. |