Gene Symbol | Dkk2 |
Entrez Gene ID | 295445 |
Full Name | dickkopf WNT signaling pathway inhibitor 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Dkk2 cDNA ORF clone
gRNAs
Gene Symbol | Dkk2 |
Entrez Gene ID | 295445 |
Full Name | dickkopf WNT signaling pathway inhibitor 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001106472.1 | NP_001099942.1 | dickkopf-related protein 2 precursor |
Homo sapiens (human) | DKK2 | NP_055236.1 |
Pan troglodytes (chimpanzee) | DKK2 | XP_001170814.1 |
Canis lupus familiaris (dog) | DKK2 | XP_535681.3 |
Danio rerio (zebrafish) | dkk2 | NP_001104679.1 |
Rattus norvegicus (Norway rat) | Dkk2 | NP_001099942.1 |
DKK2 | XP_001085254.1 | |
Bos taurus (cattle) | DKK2 | NP_001076084.1 |
Mus musculus (house mouse) | Dkk2 | NP_064661.2 |
Gallus gallus (chicken) | DKK2 | XP_420494.1 |
Xenopus tropicalis (tropical clawed frog) | dkk2 | XP_002940336.1 |
MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/?-catenin signaling pathway.
Li Q, Shen K, Zhao Y, He X, Ma C, Wang L, Wang B, Liu J, Ma J
FEBS letters587(12)1742-8(2013 Jun)
The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.
Min JK, Park H, Choi HJ, Kim Y, Pyun BJ, Agrawal V, Song BW, Jeon J, Maeng YS, Rho SS, Shim S, Chai JH, Koo BK, Hong HJ, Yun CO, Choi C, Kim YM, Hwang KC, Kwon YG
The Journal of clinical investigation121(5)1882-93(2011 May)
Function and biological roles of the Dickkopf family of Wnt modulators.
Niehrs C
Oncogene25(57)7469-81(2006 Dec)
Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.
Caricasole A, Ferraro T, Iacovelli L, Barletta E, Caruso A, Melchiorri D, Terstappen GC, Nicoletti F
The Journal of biological chemistry278(39)37024-31(2003 Sep)
Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.
Li L, Mao J, Sun L, Liu W, Wu D
The Journal of biological chemistry277(8)5977-81(2002 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
there are distinct functions of DKK1 and DKK2 in controlling angiogenesis
Title: The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.
The following Dkk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dkk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa01384 | |
Clone ID Related Accession (Same CDS sequence) | NM_001106472.1 | |
Accession Version | NM_001106472.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-27 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | dickkopf-related protein 2 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473952.1. On or before Oct 4, 2007 this sequence version replaced XM_238256.4, XM_001077211.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001099942.1 |
CDS | 744..1523 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/?-catenin signaling pathway. |
The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. |
Function and biological roles of the Dickkopf family of Wnt modulators. |
Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. |
Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. |