Slc39a8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Slc39a8
Entrez Gene ID	295455
Full Name	solute carrier family 39 member 8
General protein information	Preferred Names solute carrier family 39 member 8 Names zinc transporter ZIP8 ZIP-8 solute carrier family 39 (metal ion transporter), member 8 solute carrier family 39 (zinc transporter), member 8 zrt- and Irt-like protein 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q43

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011952.1	NP_001011952.1	zinc transporter ZIP8 precursor
XM_017590787.1	XP_017446276.1	zinc transporter ZIP8 isoform X1
XM_006233357.2	XP_006233419.1	zinc transporter ZIP8 isoform X1
XM_006233356.2	XP_006233418.1	zinc transporter ZIP8 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC39A8	NP_001128618.1
Rattus norvegicus (Norway rat)	Slc39a8	NP_001011952.1
Danio rerio (zebrafish)	LOC100002893	XP_001342563.3
Xenopus tropicalis (tropical clawed frog)	slc39a8	XP_002934812.1
	LOC710142	XP_002808462.1
Canis lupus familiaris (dog)	SLC39A8	XP_005639290.1
Mus musculus (house mouse)	Slc39a8	NP_001128621.1
Gallus gallus (chicken)	SLC39A8	XP_427970.3
Pan troglodytes (chimpanzee)	SLC39A8	XP_001168404.1
Bos taurus (cattle)	SLC39A8	NP_001192559.1
Danio rerio (zebrafish)	LOC101885679	XP_005156653.1

Gene Ontology
Bibliography

Related articles in PubMed

Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithelial cells.
Gao Y, Xu Y, Wu D, Yu F, Yang L, Yao Y, Liang Z, Lau ATY
Acta biochimica et biophysica Sinica49(5)444-449(2017 May)

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
Trends in biochemical sciences41(3)274-86(2016 Mar)

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Lane DJ, Merlot AM, Huang ML, Bae DH, Jansson PJ, Sahni S, Kalinowski DS, Richardson DR
Biochimica et biophysica acta1853(5)1130-44(2015 May)

Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.
Ding D, Salvi R, Roth JA
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine27(4)731-44(2014 Aug)

Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells.
Fujishiro H, Ohashi T, Takuma M, Himeno S
Metallomics : integrated biometal science5(5)437-44(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nuclear localization for Zip8 and Zip14 transporters as well as TfR1 was observed in the inner ear of rats.
Title: Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.

ZIP8 plays a pivotal role in the transport and toxicity of Cd(2+) and Mn(2+) in RBL-2H3 cells.
Title: Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells.

data identify ZIP8 as an iron transport protein that may function in iron metabolism.
Title: ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.

The high expression of ZIP8, which is known to have affinities for both Cd and Mn, resulted in high accumulation of Cd and Mn.
Title: High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8.

The following Slc39a8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc39a8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01707	NM_001011952.1 Latest version!	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa01707	XM_017590787.1 Latest version!	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa01707	XM_006233357.2 Latest version!	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa01707	XM_006233356.2 Latest version!	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc39a8 ( NM_001011952.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001011952.1 Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), mRNA.

Price & Availability↑

CloneID	ORa01707
Clone ID Related Accession (Same CDS sequence)	NM_001011952.1 , XM_017590787.1 , XM_006233357.2 , XM_006233356.2
Accession Version	NM_001011952.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter ZIP8 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089844.1. On Feb 11, 2005 this sequence version replaced XM_227699.2. ##Evidence-Data-START## Transcript exon combination :: BC089844.1, CB605620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011952.1
CDS	256..1644
Translation	MAPGRAVAGLLLLAATGLGRPSEGPELAFTEDVLRVFGANQSLSAAQLGRLLERLGAAPQQGALELGQLHFNQCLSAEDIFSLHGFSNVTQITSSNFTAICPAILQQLNFHPCEDPQKHSVKPSFSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKIDNYVEKAVAVFGGFYMLFFVERTLKMLLKTYGQNDHTHFRNDDFGSKEKAHQPKTLPLPPVNGVTCYANPAVTEPNGHIHFDTVSVVSLQDGKAESSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASYTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRQTDFTFFMIQNAGMLTGFTAILLITLYAGDIELQ

Target ORF information:

RefSeq Version	NM_001011952.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011952.1

ORF Insert Sequence:

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc39a8 ( XM_017590787.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446276.1 Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa01707
Clone ID Related Accession (Same CDS sequence)	NM_001011952.1 , XM_017590787.1 , XM_006233357.2 , XM_006233356.2
Accession Version	XM_017590787.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter ZIP8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446276.1
CDS	405..1793
Translation	MAPGRAVAGLLLLAATGLGRPSEGPELAFTEDVLRVFGANQSLSAAQLGRLLERLGAAPQQGALELGQLHFNQCLSAEDIFSLHGFSNVTQITSSNFTAICPAILQQLNFHPCEDPQKHSVKPSFSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKIDNYVEKAVAVFGGFYMLFFVERTLKMLLKTYGQNDHTHFRNDDFGSKEKAHQPKTLPLPPVNGVTCYANPAVTEPNGHIHFDTVSVVSLQDGKAESSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASYTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRQTDFTFFMIQNAGMLTGFTAILLITLYAGDIELQ

Target ORF information:

RefSeq Version	XM_017590787.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590787.1

ORF Insert Sequence:

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc39a8 ( XM_006233357.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233419.1 Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa01707
Clone ID Related Accession (Same CDS sequence)	NM_001011952.1 , XM_017590787.1 , XM_006233357.2 , XM_006233356.2
Accession Version	XM_006233357.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter ZIP8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006233357.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233419.1
CDS	515..1903
Translation	MAPGRAVAGLLLLAATGLGRPSEGPELAFTEDVLRVFGANQSLSAAQLGRLLERLGAAPQQGALELGQLHFNQCLSAEDIFSLHGFSNVTQITSSNFTAICPAILQQLNFHPCEDPQKHSVKPSFSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKIDNYVEKAVAVFGGFYMLFFVERTLKMLLKTYGQNDHTHFRNDDFGSKEKAHQPKTLPLPPVNGVTCYANPAVTEPNGHIHFDTVSVVSLQDGKAESSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASYTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRQTDFTFFMIQNAGMLTGFTAILLITLYAGDIELQ

Target ORF information:

RefSeq Version	XM_006233357.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233357.2

ORF Insert Sequence:

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc39a8 ( XM_006233356.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233418.1 Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X1, mRNA.

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CloneID	ORa01707
Clone ID Related Accession (Same CDS sequence)	NM_001011952.1 , XM_017590787.1 , XM_006233357.2 , XM_006233356.2
Accession Version	XM_006233356.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter ZIP8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006233356.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233418.1
CDS	295..1683
Translation	MAPGRAVAGLLLLAATGLGRPSEGPELAFTEDVLRVFGANQSLSAAQLGRLLERLGAAPQQGALELGQLHFNQCLSAEDIFSLHGFSNVTQITSSNFTAICPAILQQLNFHPCEDPQKHSVKPSFSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTYFVGLAIGTLFSNAIFQLIPEAFGFNPKIDNYVEKAVAVFGGFYMLFFVERTLKMLLKTYGQNDHTHFRNDDFGSKEKAHQPKTLPLPPVNGVTCYANPAVTEPNGHIHFDTVSVVSLQDGKAESSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASYTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRQTDFTFFMIQNAGMLTGFTAILLITLYAGDIELQ

Target ORF information:

RefSeq Version	XM_006233356.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 39 member 8 (Slc39a8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233356.2

ORF Insert Sequence:

ATGGCTCCGG GCCGGGCAGT GGCCGGGCTG CTGCTACTGG CGGCCACCGG CCTGGGACGC 
CCCTCGGAGG GGCCGGAGCT CGCCTTCACT GAGGATGTGC TGAGAGTGTT CGGCGCCAAC 
CAGAGCCTGT CGGCCGCGCA GCTGGGGCGC CTGCTGGAGC GCCTGGGGGC TGCACCCCAG 
CAGGGAGCGC TGGAGCTGGG CCAGCTCCAC TTCAACCAGT GTCTGTCAGC GGAAGACATC 
TTTTCTCTTC ATGGTTTCTC AAACGTCACC CAGATAACCA GCTCGAACTT CACTGCCATC 
TGCCCTGCGA TCTTACAGCA GCTGAACTTT CATCCCTGTG AGGATCCACA GAAGCACAGC 
GTAAAGCCCA GTTTTTCCGA AGTCTGGGGC TATGGATTCT TGTCAGTGAC AATCATCAAT 
TTGGCCTCTC TCCTGGGATT GATTTTAACC CCCTTGATAA AGAAGTCGTA TTTCCCCAAG 
ATTTTGACTT ATTTTGTGGG GCTGGCTATT GGGACCCTTT TCTCAAATGC CATTTTCCAG 
CTTATTCCAG AGGCATTTGG ATTTAATCCC AAAATTGACA ATTATGTTGA AAAGGCAGTT 
GCTGTGTTTG GTGGATTTTA CATGCTTTTC TTTGTTGAAA GAACACTTAA GATGCTACTG 
AAAACGTACG GCCAGAATGA CCATACTCAC TTCAGGAATG ATGACTTCGG TTCTAAAGAA 
AAAGCCCATC AACCCAAAAC GTTGCCATTA CCTCCTGTCA ATGGAGTGAC ATGCTATGCC 
AACCCCGCTG TCACTGAGCC TAATGGACAC ATCCACTTCG ACACTGTCAG TGTTGTGTCC 
CTGCAGGATG GAAAAGCAGA GTCAAGTTCA TGCACCTGTT TGAAGGGGCC CAAACTGTCA 
GAAATAGGAA CGATTGCTTG GATGATCACG CTCTGTGATG CCCTTCACAA TTTCATTGAT 
GGCTTGGCGA TCGGGGCATC CTATACTCTG TCTCTTCTTC AAGGACTCAG TACTTCCATA 
GCGATCCTGT GTGAGGAGTT TCCTCATGAG TTAGGGGACT TTGTGATCTT GCTCAATGCA 
GGGATGAGCA CTCGGCAAGC CTTGCTGTTT AACTTCCTCT CTGCATGTTC CTGCTACGTT 
GGGCTTGCTT TCGGCATTTT GGTGGGCAAC AACTTTGCTC CAAATATTAT ATTTGCACTT 
GCTGGAGGCA TGTTCCTTTA CATTTCTCTG GCAGATATGT TTCCAGAGAT GAACGACATG 
CTGAGAGAAA AAGTAACTGG AAGACAAACG GACTTCACCT TCTTCATGAT CCAGAACGCA 
GGGATGTTAA CCGGATTCAC TGCCATCTTG CTCATCACCT TGTACGCAGG GGACATCGAA 
TTGCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Progressive silencing of the zinc transporter Zip8 (Slc39a8) in chronic cadmium-exposed lung epithelial cells.
Acta biochimica et biophysica Sinica49(5)444-449(2017 May)
Gao Y,Xu Y,Wu D,Yu F,Yang L,Yao Y,Liang Z,Lau ATY

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Trends in biochemical sciences41(3)274-86(2016 Mar)
Bogdan AR,Miyazawa M,Hashimoto K,Tsuji Y

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Biochimica et biophysica acta1853(5)1130-44(2015 May)
Lane DJ,Merlot AM,Huang ML,Bae DH,Jansson PJ,Sahni S,Kalinowski DS,Richardson DR

Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine27(4)731-44(2014 Aug)
Ding D,Salvi R,Roth JA

Suppression of ZIP8 expression is a common feature of cadmium-resistant and manganese-resistant RBL-2H3 cells.
Metallomics : integrated biometal science5(5)437-44(2013 May)
Fujishiro H,Ohashi T,Takuma M,Himeno S

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Slc39a8 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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