Gene Symbol | Ecsit |
Entrez Gene ID | 300447 |
Full Name | ECSIT signalling integrator |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Ecsit cDNA ORF clone
Gene Symbol | Ecsit |
Entrez Gene ID | 300447 |
Full Name | ECSIT signalling integrator |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006242636.3 | XP_006242698.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 |
XM_017595531.1 | XP_017451020.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X3 |
XM_017595532.1 | XP_017451021.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X4 |
XM_006242637.3 | XP_006242699.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 |
XM_006242638.3 | XP_006242700.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2 |
NM_001006986.1 | NP_001006987.1 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor |
Homo sapiens (human) | ECSIT | NP_057665.2 |
Pan troglodytes (chimpanzee) | ECSIT | XP_512396.2 |
LOC714805 | XP_001106441.1 | |
Canis lupus familiaris (dog) | ECSIT | XP_542054.2 |
Mus musculus (house mouse) | Ecsit | NP_001240826.1 |
Danio rerio (zebrafish) | ecsit | NP_001229867.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005295 | XP_309087.4 |
Caenorhabditis elegans (roundworm) | Y17G9B.5 | NP_500631.1 |
Xenopus tropicalis (tropical clawed frog) | ecsit | NP_001072411.1 |
Bos taurus (cattle) | ECSIT | NP_001029458.1 |
Rattus norvegicus (Norway rat) | Ecsit | NP_001006987.1 |
Gallus gallus (chicken) | ECSIT | XP_003643592.1 |
Drosophila melanogaster (fruit fly) | ECSIT | NP_649602.2 |
TRIM59 interacts with ECSIT and negatively regulates NF-?B and IRF-3/7-mediated signal pathways.
Kondo T, Watanabe M, Hatakeyama S
Biochemical and biophysical research communications422(3)501-7(2012 Jun)
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.
Vogel RO, Janssen RJ, van den Brand MA, Dieteren CE, Verkaart S, Koopman WJ, Willems PH, Pluk W, van den Heuvel LP, Smeitink JA, Nijtmans LG
Genes & development21(5)615-24(2007 Mar)
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
Xiao C, Shim JH, Kl?ppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S
Genes & development17(23)2933-49(2003 Dec)
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S
Genes & development13(16)2059-71(1999 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Ecsit gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ecsit cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa12485 | |
Clone ID Related Accession (Same CDS sequence) | XM_006242638.3 , NM_001006986.1 | |
Accession Version | NM_001006986.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083762.1. On Nov 22, 2004 this sequence version replaced XM_217092.2. ##Evidence-Data-START## Transcript exon combination :: BC083762.1, FQ209658.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001006987.1 |
CDS | 75..1379 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001006986.1 |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa12485 | |
Clone ID Related Accession (Same CDS sequence) | XM_006242638.3 , NM_001006986.1 | |
Accession Version | XM_006242638.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242638.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006242700.1 |
CDS | 114..1418 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006242638.3 |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa30909 | |
Clone ID Related Accession (Same CDS sequence) | XM_006242636.3 , XM_006242637.3 | |
Accession Version | XM_006242636.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242636.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006242698.1 |
CDS | 124..1446 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006242636.3 |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa30909 | |
Clone ID Related Accession (Same CDS sequence) | XM_006242636.3 , XM_006242637.3 | |
Accession Version | XM_006242637.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242637.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006242699.1 |
CDS | 114..1436 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006242637.3 |
1 | ATGAGCTGGG TACAGGTCAA CTTGCTGGCC CGAGGCCTCT CCAGGGGCTG GGGCAGCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa62360 | |
Clone ID Related Accession (Same CDS sequence) | XM_017595532.1 | |
Accession Version | XM_017595532.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCACGAAG ACCTGTTCAG GCCATCAGGA AACGGGGAGC AGGACAAGGC AAGCTTCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017451021.1 |
CDS | 202..1299 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017595532.1 |
1 | ATGCACGAAG ACCTGTTCAG GCCATCAGGA AACGGGGAGC AGGACAAGGC AAGCTTCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa62359 | |
Clone ID Related Accession (Same CDS sequence) | XM_017595531.1 | |
Accession Version | XM_017595531.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCACGAAG ACCTGTTCAG GCCATCAGGA AACGGGGAGC AGGACAAGGC AAGCTTCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017451020.1 |
CDS | 204..1319 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017595531.1 |
1 | ATGCACGAAG ACCTGTTCAG GCCATCAGGA AACGGGGAGC AGGACAAGGC AAGCTTCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
TRIM59 interacts with ECSIT and negatively regulates NF-?B and IRF-3/7-mediated signal pathways. |
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. |
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. |
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. |