Gene Symbol | Spry2 |
Entrez Gene ID | 306141 |
Full Name | sprouty RTK signaling antagonist 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Spry2 cDNA ORF clone
gRNAs
Gene Symbol | Spry2 |
Entrez Gene ID | 306141 |
Full Name | sprouty RTK signaling antagonist 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001012046.1 | NP_001012046.1 | protein sprouty homolog 2 |
XM_006252438.3 | XP_006252500.1 | protein sprouty homolog 2 isoform X1 |
Pan troglodytes (chimpanzee) | SPRY2 | XP_003952460.1 |
Bos taurus (cattle) | SPRY2 | NP_001069615.1 |
SPRY2 | XP_001090386.2 | |
Canis lupus familiaris (dog) | SPRY2 | XP_005634066.1 |
Rattus norvegicus (Norway rat) | Spry2 | NP_001012046.1 |
Mus musculus (house mouse) | Spry2 | NP_036027.1 |
Danio rerio (zebrafish) | spry2 | NP_001003842.2 |
Xenopus tropicalis (tropical clawed frog) | spry2 | NP_001006932.2 |
Homo sapiens (human) | SPRY2 | NP_005833.1 |
Gallus gallus (chicken) | SPRY2 | NP_990131.1 |
Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.
Yim DG, Ghosh S, Guy GR, Virshup DM
Oncogene34(4)474-84(2015 Jan)
Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats.
Dow AL, Lin TV, Chartoff EH, Potter D, McPhie DL, Van't Veer AV, Knoll AT, Lee KN, Neve RL, Patel TB, Ongur D, Cohen BM, Carlezon WA Jr
PloS one10(3)e0120693(2015)
MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.
Wang JM, Tao J, Chen DD, Cai JJ, Irani K, Wang Q, Yuan H, Chen AF
Arteriosclerosis, thrombosis, and vascular biology34(1)99-109(2014 Jan)
Spatiotemporal alterations in Sprouty-2 expression and tyrosine phosphorylation in nitrofen-induced pulmonary hypoplasia.
Friedmacher F, Gosemann JH, Fujiwara N, Alvarez LA, Corcionivoschi N, Puri P
Journal of pediatric surgery48(11)2219-25(2013 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CK1 activity and binding are necessary for SPRY2 inhibition of FGF-stimulated neurite outgrowth in PC12 cells
Title: Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.
SPRY2 negatively regulates fibroblast growth factor-2.
Title: Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats.
Decreased expression of Sproutys and SPREDs during the terminal pseudoglandular stage may disrupt lung branching morphogenesis by interfering with epithelial-mesenchymal interactions contributing to PH.
Title: Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia.
Spry2 mRNA, protein, and tyrosination on D18 and D21 were significantly decreased in hypoplastic lungs with and without congenital diaphragmatic hernia.
Title: Spatiotemporal alterations in Sprouty-2 expression and tyrosine phosphorylation in nitrofen-induced pulmonary hypoplasia.
A comparison the distribution of Sprouty-1 and Sprouty-2 proteins by immunohistochemistry in developing and adult rat lung.
Title: Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung.
The following Spry2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spry2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa02050 | |
Clone ID Related Accession (Same CDS sequence) | NM_001012046.1 , XM_006252438.3 | |
Accession Version | NM_001012046.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-18 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | protein sprouty homolog 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089116.1. On Feb 11, 2005 this sequence version replaced XM_224515.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089116.1, CO399410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGGCCA GAGCTCAGAG CGGCAGCGGG TCGCAGCCTT TGCTGCAGTC ACCCCATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001012046.1 |
CDS | 218..1162 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGCCA GAGCTCAGAG CGGCAGCGGG TCGCAGCCTT TGCTGCAGTC ACCCCATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa02050 | |
Clone ID Related Accession (Same CDS sequence) | NM_001012046.1 , XM_006252438.3 | |
Accession Version | XM_006252438.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | protein sprouty homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252438.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGCCA GAGCTCAGAG CGGCAGCGGG TCGCAGCCTT TGCTGCAGTC ACCCCATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006252500.1 |
CDS | 514..1458 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGGCCA GAGCTCAGAG CGGCAGCGGG TCGCAGCCTT TGCTGCAGTC ACCCCATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. |
Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats. |
MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. |
Spatiotemporal alterations in Sprouty-2 expression and tyrosine phosphorylation in nitrofen-induced pulmonary hypoplasia. |