Thap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Thap1
Entrez Gene ID	306547
Full Name	THAP domain containing 1
General protein information	Preferred Names THAP domain containing 1 Names THAP domain-containing protein 1 THAP domain-containing apoptosis-associated protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.4

mRNA and Protein(s)

mRNA Protein Name

NM_001008340.1 NP_001008341.1 THAP domain-containing protein 1
Pathways from BioSystems

mRNA	Protein	Name
NM_001008340.1	NP_001008341.1	THAP domain-containing protein 1

Homologies

Homo sapiens (human)	THAP1	NP_060575.1
Gallus gallus (chicken)	THAP1	XP_004949398.1
Canis lupus familiaris (dog)	THAP1	XP_848435.1
Rattus norvegicus (Norway rat)	Thap1	NP_001008341.1
Xenopus tropicalis (tropical clawed frog)	thap1	NP_001006738.1
Mus musculus (house mouse)	Thap1	NP_950243.1
Pan troglodytes (chimpanzee)	THAP1	XP_528123.1
	THAP1	XP_001099355.1
Bos taurus (cattle)	THAP1	NP_001029820.1

Gene Ontology
Bibliography

Related articles in PubMed

In-depth Characterization of the Homodimerization Domain of the Transcription Factor THAP1 and Dystonia-Causing Mutations Therein.
Richter A, Hollstein R, Hebert E, Vulinovic F, Eckhold J, Osmanovic A, Depping R, Kaiser FJ, Lohmann K
Journal of molecular neuroscience : MN62(1)11-16(2017 May)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Neural expression of the transcription factor THAP1 during development in rat.
Zhao Y, Xiao J, Gong S, Clara JA, Ledoux MS
Neuroscience231282-95(2013 Feb)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6).
Kaiser FJ, Osmanoric A, Rakovic A, Erogullari A, Uflacker N, Braunholz D, Lohnau T, Orolicki S, Albrecht M, Gillessen-Kaesbach G, Klein C, Lohmann K
Annals of neurology68(4)554-9(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The prominent cytoplasmic and developmentally regulated expression of THAP1 suggests that THAP1 may function as part of a cell surface-nucleus signaling cascade involved in terminal neural differentiation.
Title: Neural expression of the transcription factor THAP1 during development in rat.

The following Thap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Thap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11595	NM_001008340.1 Latest version!	Rattus norvegicus THAP domain containing 1 (Thap1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Thap1 ( NM_001008340.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001008341.1 Rattus norvegicus THAP domain containing 1 (Thap1), mRNA.

Price & Availability↑

CloneID	ORa11595
Clone ID Related Accession (Same CDS sequence)	NM_001008340.1
Accession Version	NM_001008340.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-14
Organism	Rattus norvegicus(Norway rat)
Product	THAP domain-containing protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086347.1. On Dec 16, 2004 this sequence version replaced XM_224951.2. ##Evidence-Data-START## Transcript exon combination :: BC086347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGCAGT CCTGTTCCGC CTACGGCTGC AAGAACCGGT ACGATAAGGA CAAGCCCGTC 
TCCTTCCACA AGTTTCCTCT TACTCGTCCC AGTCTTTGTA AACAGTGGGA GGCAGCTGTT 
AGAAGGAAAA ACTTCAAGCC CACTAAGTAC AGCAGTATCT GTTCGGAGCA CTTTACTCCA 
GACTGCTTTA AGAGAGAGTG CAACAACAAG CTACTGAAGG AGAACGCTGT GCCCACTATT 
TTTCTCTATA TAGAGCCACA TGAGAAGAAG GAAGAACTGG AACCCCAAGA GCAGCTTCCC 
TCTCCTTCAC CCCCCACTTC CCAGGTTGAC GCCGCTGTTG GGTTGCTAAT GCCTCCTCTC 
CAGACCCCTG ATAACCTCTC AGTTTTCTGT GACCACAACT ACACTGTGGA GGACACAATG 
CACCAGAGGA AGAGGATCCT TCACCTGGAG CAGCAGGTTG AAAAGCTCAG GAAGAAACTC 
AAGACCGCCC AGCAGCGGTG CCGTCGGCAG GAGAGACAGC TCGAGAAGCT CAAGGAAGTT 
GTACACTTTC AGAGAGAGAA AGACGACGCC TCGGAGAGGG GCTATGTGAT TCTACCAAAT 
GACTACTTCG AAATTGTTGA AGTGCCAGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008341.1
CDS	234..866
Translation	MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLYIEPHEKKEELEPQEQLPSPSPPTSQVDAAVGLLMPPLQTPDNLSVFCDHNYTVEDTMHQRKRILHLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQREKDDASERGYVILPNDYFEIVEVPA

Target ORF information:

RefSeq Version	NM_001008340.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus THAP domain containing 1 (Thap1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008340.1

ORF Insert Sequence:

ATGGTGCAGT CCTGTTCCGC CTACGGCTGC AAGAACCGGT ACGATAAGGA CAAGCCCGTC 
TCCTTCCACA AGTTTCCTCT TACTCGTCCC AGTCTTTGTA AACAGTGGGA GGCAGCTGTT 
AGAAGGAAAA ACTTCAAGCC CACTAAGTAC AGCAGTATCT GTTCGGAGCA CTTTACTCCA 
GACTGCTTTA AGAGAGAGTG CAACAACAAG CTACTGAAGG AGAACGCTGT GCCCACTATT 
TTTCTCTATA TAGAGCCACA TGAGAAGAAG GAAGAACTGG AACCCCAAGA GCAGCTTCCC 
TCTCCTTCAC CCCCCACTTC CCAGGTTGAC GCCGCTGTTG GGTTGCTAAT GCCTCCTCTC 
CAGACCCCTG ATAACCTCTC AGTTTTCTGT GACCACAACT ACACTGTGGA GGACACAATG 
CACCAGAGGA AGAGGATCCT TCACCTGGAG CAGCAGGTTG AAAAGCTCAG GAAGAAACTC 
AAGACCGCCC AGCAGCGGTG CCGTCGGCAG GAGAGACAGC TCGAGAAGCT CAAGGAAGTT 
GTACACTTTC AGAGAGAGAA AGACGACGCC TCGGAGAGGG GCTATGTGAT TCTACCAAAT 
GACTACTTCG AAATTGTTGA AGTGCCAGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In-depth Characterization of the Homodimerization Domain of the Transcription Factor THAP1 and Dystonia-Causing Mutations Therein.
Journal of molecular neuroscience : MN62(1)11-16(2017 May)
Richter A,Hollstein R,Hebert E,Vulinovic F,Eckhold J,Osmanovic A,Depping R,Kaiser FJ,Lohmann K

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Neural expression of the transcription factor THAP1 during development in rat.
Neuroscience231282-95(2013 Feb)
Zhao Y,Xiao J,Gong S,Clara JA,Ledoux MS

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6).
Annals of neurology68(4)554-9(2010 Oct)
Kaiser FJ,Osmanoric A,Rakovic A,Erogullari A,Uflacker N,Braunholz D,Lohnau T,Orolicki S,Albrecht M,Gillessen-Kaesbach G,Klein C,Lohmann K

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Thap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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