Gene Symbol | Sirt5 |
Entrez Gene ID | 306840 |
Full Name | sirtuin 5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Sirt5 cDNA ORF clone
Gene Symbol | Sirt5 |
Entrez Gene ID | 306840 |
Full Name | sirtuin 5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006253801.1 | XP_006253863.1 | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 |
XM_006253803.3 | XP_006253865.1 | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 |
XM_017600521.1 | XP_017456010.1 | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 |
XM_006253802.2 | XP_006253864.1 | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 |
NM_001004256.1 | NP_001004256.1 | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
XM_006253804.3 | XP_006253866.1 | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 |
Gallus gallus (chicken) | SIRT5 | NP_001263293.1 |
Canis lupus familiaris (dog) | SIRT5 | XP_535891.2 |
Eremothecium gossypii | AGOS_ABL004W | NP_982943.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_15048 | XP_003721315.1 |
Xenopus tropicalis (tropical clawed frog) | sirt5 | NP_001263631.1 |
SIRT5 | XP_001091987.1 | |
Mus musculus (house mouse) | Sirt5 | NP_849179.1 |
Rattus norvegicus (Norway rat) | Sirt5 | NP_001004256.1 |
Homo sapiens (human) | SIRT5 | NP_036373.1 |
Pan troglodytes (chimpanzee) | SIRT5 | XP_001169506.1 |
Bos taurus (cattle) | SIRT5 | NP_001029467.1 |
Danio rerio (zebrafish) | sirt5 | NP_001002605.1 |
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
Yang X, Wang Z, Li X, Liu B, Liu M, Liu L, Chen S, Ren M, Wang Y, Yu M, Wang B, Zou J, Zhu WG, Yin Y, Gu W, Luo J
Cancer research78(2)372-386(2018 Jan)
Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
Martin J, Balmer ML, Rajendran S, Maurhofer O, Dufour JF, St-Pierre MV
American journal of physiology. Gastrointestinal and liver physiology310(7)G497-509(2016 Apr)
NAD? in aging, metabolism, and neurodegeneration.
Verdin E
Science (New York, N.Y.)350(6265)1208-13(2015 Dec)
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, M?hlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y
Cell metabolism19(4)605-17(2014 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Caloric restriction (CR) retarded declines in cognitive ability and enhanced the expression of both SIRT1 and SIRT5 proteins in the cerebral tissue of CR rats compared with AL rats
Title: SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction.
Alcohol decreases mitochondrial SIRT5 level.
Title: Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function.
The following Sirt5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sirt5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa12398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006253801.1 , XM_006253803.3 , XM_017600521.1 , XM_006253802.2 , NM_001004256.1 , XM_006253804.3 | |
Accession Version | NM_001004256.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-24 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacylase sirtuin-5, mitochondrial | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078958.1. On Sep 10, 2004 this sequence version replaced XM_225227.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001004256.1 |
CDS | 48..980 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001004256.1 |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa12398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006253801.1 , XM_006253803.3 , XM_017600521.1 , XM_006253802.2 , NM_001004256.1 , XM_006253804.3 | |
Accession Version | XM_006253801.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006253863.1 |
CDS | 232..1164 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006253801.1 |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa12398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006253801.1 , XM_006253803.3 , XM_017600521.1 , XM_006253802.2 , NM_001004256.1 , XM_006253804.3 | |
Accession Version | XM_006253803.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006253803.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006253865.1 |
CDS | 115..1047 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006253803.3 |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa12398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006253801.1 , XM_006253803.3 , XM_017600521.1 , XM_006253802.2 , NM_001004256.1 , XM_006253804.3 | |
Accession Version | XM_017600521.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017456010.1 |
CDS | 59..991 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017600521.1 |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa12398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006253801.1 , XM_006253803.3 , XM_017600521.1 , XM_006253802.2 , NM_001004256.1 , XM_006253804.3 | |
Accession Version | XM_006253802.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006253802.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006253864.1 |
CDS | 215..1147 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006253802.2 |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa12398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006253801.1 , XM_006253803.3 , XM_017600521.1 , XM_006253802.2 , NM_001004256.1 , XM_006253804.3 | |
Accession Version | XM_006253804.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006253804.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006253866.1 |
CDS | 59..991 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006253804.3 |
1 | ATGCGACCGC TCCCGGTCGC TCCCGGACGT CTCTTCTCCC AGCTGTGTTG TGGACCGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation. |
Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. |
NAD? in aging, metabolism, and neurodegeneration. |
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. |