Gene Symbol | Traf6 |
Entrez Gene ID | 311245 |
Full Name | TNF receptor associated factor 6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Traf6 cDNA ORF clone
Gene Symbol | Traf6 |
Entrez Gene ID | 311245 |
Full Name | TNF receptor associated factor 6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001107754.2 | NP_001101224.1 | TNF receptor-associated factor 6 |
Pan troglodytes (chimpanzee) | TRAF6 | XP_001154136.1 |
Rattus norvegicus (Norway rat) | Traf6 | NP_001101224.1 |
Danio rerio (zebrafish) | traf6 | NP_001038217.1 |
Drosophila melanogaster (fruit fly) | Traf6 | NP_511080.2 |
Xenopus tropicalis (tropical clawed frog) | traf6 | NP_001008162.2 |
TRAF6 | NP_001129268.1 | |
Bos taurus (cattle) | TRAF6 | NP_001029833.1 |
Mus musculus (house mouse) | Traf6 | NP_033450.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003004 | XP_311879.5 |
Homo sapiens (human) | TRAF6 | NP_665802.1 |
Canis lupus familiaris (dog) | TRAF6 | XP_003432370.1 |
Gallus gallus (chicken) | TRAF6 | XP_004941604.1 |
MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-?B pathway.
He X, Zheng Y, Liu S, Shi S, Liu Y, He Y, Zhang C, Zhou X
Journal of cellular physiology233(3)2476-2488(2018 Mar)
Effect of N-Acetylserotonin on TLR-4 and MyD88 Expression during Intestinal Ischemia-Reperfusion in a Rat Model.
Sukhotnik I, Ben Shahar Y, Halabi S, Bitterman N, Dorfman T, Pollak Y, Coran A, Bitterman A
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie(2018 Jan)
Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress.
Dou Y, Shen H, Feng D, Li H, Tian X, Zhang J, Wang Z, Chen G
Journal of neurochemistry142(3)478-492(2017 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
miR-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4, TRAF6, and p-IkappaBalpha, subsequently leading to decreased NF-kappaB p65 nuclear translocation.
Title: MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-?B pathway.
showed that application of TRAF6 over-expression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve EBI after SAH, including neuronal death, brain edema, and blood-brain barrier injury
Title: Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress.
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Title: TRAF6 Mediates Suppression of Osteoclastogenesis and Prevention of Ovariectomy-Induced Bone Loss by a Novel Prenylflavonoid.
As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions.
Title: MicroRNA-146a Contributes to SCI Recovery via Regulating
MiR-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway.
Title: MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway.
The following Traf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Traf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa12566 | |
Clone ID Related Accession (Same CDS sequence) | NM_001107754.2 | |
Accession Version | NM_001107754.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-14 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | TNF receptor-associated factor 6 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168921.1. On Sep 4, 2008 this sequence version replaced NM_001107754.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGTCTCT TAAACTGTGA AAACAGCTGT GCGTCCAGCC AGTCTTCAAG CGACTGCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001101224.1 |
CDS | 191..1783 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001107754.2 |
1 | ATGAGTCTCT TAAACTGTGA AAACAGCTGT GCGTCCAGCC AGTCTTCAAG CGACTGCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-?B pathway. |
Effect of N-Acetylserotonin on TLR-4 and MyD88 Expression during Intestinal Ischemia-Reperfusion in a Rat Model. |
Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress. |