Fzr1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Fzr1 |
| Entrez Gene ID | 314642 |
| Full Name | fizzy and cell division cycle 20 related 1 |
| Synonyms | Cdh1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001108074.2 | NP_001101544.2 | fizzy-related protein homolog |
| Homo sapiens (human) | FZR1 | NP_057347.2 |
| Canis lupus familiaris (dog) | FZR1 | XP_005633132.1 |
| Rattus norvegicus (Norway rat) | Fzr1 | NP_001101544.2 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002114 | XP_320924.5 |
| Caenorhabditis elegans (roundworm) | fzr-1 | NP_496075.1 |
| Kluyveromyces lactis | KLLA0A08822g | XP_451387.1 |
| Oryza sativa (rice) | Os01g0972900 | NP_001045543.1 |
| Mus musculus (house mouse) | Fzr1 | NP_062731.1 |
| Drosophila melanogaster (fruit fly) | rap | NP_524852.2 |
| Eremothecium gossypii | AGOS_AFL007C | NP_985541.2 |
| Schizosaccharomyces pombe (fission yeast) | srw1 | NP_594674.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_06892 | XP_003709620.1 |
| Xenopus tropicalis (tropical clawed frog) | fzr1 | NP_001120001.1 |
| FZR1 | XP_001117911.2 | |
| Bos taurus (cattle) | FZR1 | NP_001032698.1 |
| Gallus gallus (chicken) | CDH1-A | NP_001265019.1 |
| Danio rerio (zebrafish) | fzr1 | NP_956547.1 |
| Saccharomyces cerevisiae (baker's yeast) | CDH1 | NP_011512.1 |
| Arabidopsis thaliana (thale cress) | FZR3 | NP_196888.2 |
| Neurospora crassa | NCU01269 | XP_960747.1 |
Related articles in PubMed
A? Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.
Fuchsberger T, Mart?nez-Bellver S, Giraldo E, Teruel-Mart? V, Lloret A, Vi?a J
Scientific reports631158(2016 Aug)
Alleviating neuropathic pain mechanical allodynia by increasing Cdh1 in the anterior cingulate cortex.
Tan W, Yao WL, Hu R, Lv YY, Wan L, Zhang CH, Zhu C
Molecular pain1156(2015 Sep)
The involvement of down-regulation of Cdh1-APC in hippocampal neuronal apoptosis after global cerebral ischemia in rat.
Zhang Y, Yao W, Qiu J, Qian W, Zhu C, Zhang C
Neuroscience letters505(2)71-5(2011 Nov)
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM
Molecular cell42(4)511-23(2011 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results provide evidence that Cdh1 in anterior cingulate cortex synapses may offer a novel therapeutic strategy for treating chronic neuropathic pain
Title: Alleviating neuropathic pain mechanical allodynia by increasing Cdh1 in the anterior cingulate cortex.
Down-regulation of Cdh1 and coactivator anaphase-promoting complex (APC) is associated with neuronal apoptosis in the hippocampus following global cerebral ischemia.
Title: The involvement of down-regulation of Cdh1-APC in hippocampal neuronal apoptosis after global cerebral ischemia in rat.
Results show that Pfkfb3 is absent from neurons in the brain cortex and that Pfkfb3 in neurons is constantly subject to proteasomal degradation by the action of the E3 ubiquitin ligase, anaphase-promoting complex/cyclosome (APC/C)-Cdh1.
Title: The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.
The following Fzr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fzr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa00248 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001108074.2 | |
| Accession Version | NM_001108074.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-14 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | fizzy-related protein homolog | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC162059.1. On Nov 19, 2011 this sequence version replaced NM_001108074.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC162059.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGACCAGG ACTATGAGCG ACGGCTCCTG CGACAGATCA TCATCCAAAA TGAGAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001101544.2 |
| CDS | 168..1649 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001108074.2 |
ORF Insert Sequence:
1 | ATGGACCAGG ACTATGAGCG ACGGCTCCTG CGACAGATCA TCATCCAAAA TGAGAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
A? Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival. |
|
Alleviating neuropathic pain mechanical allodynia by increasing Cdh1 in the anterior cingulate cortex. |
|
The involvement of down-regulation of Cdh1-APC in hippocampal neuronal apoptosis after global cerebral ischemia in rat. |
|
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. |