Gene Symbol | Gpc4 |
Entrez Gene ID | 317322 |
Full Name | glypican 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Gpc4 cDNA ORF clone
gRNAs
Gene Symbol | Gpc4 |
Entrez Gene ID | 317322 |
Full Name | glypican 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001014108.1 | NP_001014130.1 | glypican-4 precursor |
XM_006257580.3 | XP_006257642.1 | glypican-4 isoform X1 |
Rattus norvegicus (Norway rat) | Gpc4 | NP_001014130.1 |
Bos taurus (cattle) | GPC4 | NP_001192713.1 |
Mus musculus (house mouse) | Gpc4 | NP_032176.2 |
Gallus gallus (chicken) | GPC4 | XP_420222.3 |
Danio rerio (zebrafish) | gpc4 | NP_571935.2 |
Xenopus tropicalis (tropical clawed frog) | gpc4 | XP_002932634.1 |
Canis lupus familiaris (dog) | GPC4 | XP_549265.2 |
GPC4 | XP_001097252.1 | |
Drosophila melanogaster (fruit fly) | dlp | NP_996075.2 |
Caenorhabditis elegans (roundworm) | gpn-1 | NP_510582.1 |
Homo sapiens (human) | GPC4 | NP_001439.2 |
Pan troglodytes (chimpanzee) | GPC4 | XP_529161.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003559 | XP_313306.5 |
Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.
Xiong Y, Zhang Y, Zheng F, Yang Y, Xu X, Wang W, Zhu B, Wang X
Biochemical and biophysical research communications478(1)241-246(2016 09)
PTP? functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Ko JS, Pramanik G, Um JW, Shim JS, Lee D, Kim KH, Chung GY, Condomitti G, Kim HM, Kim H, de Wit J, Park KS, Tabuchi K, Ko J
Proceedings of the National Academy of Sciences of the United States of America112(6)1874-9(2015 Feb)
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)
Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.
de Wit J, O'Sullivan ML, Savas JN, Condomitti G, Caccese MC, Vennekens KM, Yates JR 3rd, Ghosh A
Neuron79(4)696-711(2013 Aug)
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
Allen NJ, Bennett ML, Foo LC, Wang GX, Chakraborty C, Smith SJ, Barres BA
Nature486(7403)410-4(2012 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
According to behavioral studies, downregulation of Gpc4 by Gpc4 siRNA decreased spontaneous seizure frequency, while upregulation of Gpc4 by recombinant Gpc4 overexpression led to a converse result. These findings support the hypothesis that increased expression of Gpc4 in the brain is associated with epileptic seizures.
Title: Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.
GPC-4 showed strong (nanomolar) affinity and heparan sulfate-dependent interaction with the Ig domains of PTPsigma in rat brain synapses.
Title: PTP? functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
Title: Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors.
The following Gpc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa05002 | |
Clone ID Related Accession (Same CDS sequence) | NM_001014108.1 , XM_006257580.3 | |
Accession Version | NM_001014108.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-18 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | glypican-4 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081962.1. On Apr 20, 2005 this sequence version replaced XM_228677.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081962.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001014130.1 |
CDS | 516..2189 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa05002 | |
Clone ID Related Accession (Same CDS sequence) | NM_001014108.1 , XM_006257580.3 | |
Accession Version | XM_006257580.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | glypican-4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006257580.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006257642.1 |
CDS | 125..1798 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCACGGT TAGGCTTGCT CGCGCTTCTC TGCACTCTGG CGGCGCTCAG CGCCTCGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures. |
PTP? functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. |
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. |
Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development. |
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. |