Gene Symbol | Rabgef1 |
Entrez Gene ID | 360797 |
Full Name | RAB guanine nucleotide exchange factor 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Rabgef1 cDNA ORF clone
gRNAs
Gene Symbol | Rabgef1 |
Entrez Gene ID | 360797 |
Full Name | RAB guanine nucleotide exchange factor 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006249239.3 | XP_006249301.1 | rab5 GDP/GTP exchange factor isoform X2 |
XM_006249240.3 | XP_006249302.1 | rab5 GDP/GTP exchange factor isoform X2 |
NM_001108333.1 | NP_001101803.1 | rab5 GDP/GTP exchange factor |
XM_017598389.1 | XP_017453878.1 | rab5 GDP/GTP exchange factor isoform X1 |
LOC695887 | XP_002803299.1 | |
Mus musculus (house mouse) | Rabgef1 | NP_001185988.1 |
Drosophila melanogaster (fruit fly) | Rabex-5 | NP_612093.1 |
Pan troglodytes (chimpanzee) | RABGEF1 | XP_003318527.1 |
Rattus norvegicus (Norway rat) | Rabgef1 | NP_001101803.1 |
Homo sapiens (human) | RABGEF1 | NP_001273990.1 |
Canis lupus familiaris (dog) | RABGEF1 | XP_005620983.1 |
Bos taurus (cattle) | RABGEF1 | NP_777016.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005551 | XP_315556.4 |
Caenorhabditis elegans (roundworm) | rabx-5 | NP_499337.3 |
Oryza sativa (rice) | Os03g0842700 | NP_001051858.1 |
Danio rerio (zebrafish) | rabgef1 | NP_957137.1 |
RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.
Tam SY, Lilla JN, Chen CC, Kalesnikoff J, Tsai M
PloS one10(11)e0142935(2015)
RabGEFs are a major determinant for specific Rab membrane targeting.
Bl?mer J, Rey J, Dehmelt L, Mazel T, Wu YW, Bastiaens P, Goody RS, Itzen A
The Journal of cell biology200(3)287-300(2013 Feb)
Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA
The Journal of cell biology191(2)367-81(2010 Oct)
Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells.
Kalesnikoff J, Rios EJ, Chen CC, Alejandro Barbieri M, Tsai M, Tam SY, Galli SJ
Blood109(12)5308-17(2007 Jun)
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells.
Kalesnikoff J, Rios EJ, Chen CC, Nakae S, Zabel BA, Butcher EC, Tsai M, Tam SY, Galli SJ
Proceedings of the National Academy of Sciences of the United States of America103(8)2659-64(2006 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our data suggest that RabGEF1 is a negative regulator of TrkA-dependent neuronal differentiation and of NMDA receptor-mediated signaling activation in NGF-differentiated PC12 cells.
Title: RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.
The following Rabgef1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rabgef1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa07156 | |
Clone ID Related Accession (Same CDS sequence) | NM_001108333.1 | |
Accession Version | NM_001108333.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | rab5 GDP/GTP exchange factor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473973.1. On or before Oct 4, 2007 this sequence version replaced XM_341067.3, XM_001072217.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCTTTCTC ACTCCTTGGT TATCAGGAAG AAGATGAGCC TGAAGTCCGA ACGCCGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001101803.1 |
CDS | 202..1710 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTTTCTC ACTCCTTGGT TATCAGGAAG AAGATGAGCC TGAAGTCCGA ACGCCGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa34831 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249239.3 , XM_006249240.3 | |
Accession Version | XM_006249239.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | rab5 GDP/GTP exchange factor isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249239.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCCTGA AGTCCGAACG CCGGGGAATT CATGTGGATC AGTCGGAGCT CCTGTGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249301.1 |
CDS | 97..1575 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCCTGA AGTCCGAACG CCGGGGAATT CATGTGGATC AGTCGGAGCT CCTGTGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa34831 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249239.3 , XM_006249240.3 | |
Accession Version | XM_006249240.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | rab5 GDP/GTP exchange factor isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249240.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCCTGA AGTCCGAACG CCGGGGAATT CATGTGGATC AGTCGGAGCT CCTGTGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249302.1 |
CDS | 81..1559 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGCCTGA AGTCCGAACG CCGGGGAATT CATGTGGATC AGTCGGAGCT CCTGTGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa57855 | |
Clone ID Related Accession (Same CDS sequence) | XM_017598389.1 | |
Accession Version | XM_017598389.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | rab5 GDP/GTP exchange factor isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTTTCTC ACTCCTTGGT TATCAGGAAG AAGATGAGCC TGAAGTCCGA ACGCCGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017453878.1 |
CDS | 1273..2784 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTTTCTC ACTCCTTGGT TATCAGGAAG AAGATGAGCC TGAAGTCCGA ACGCCGGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells. |
RabGEFs are a major determinant for specific Rab membrane targeting. |
Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. |
Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells. |
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells. |