Gene Symbol | Gas8 |
Entrez Gene ID | 361438 |
Full Name | growth arrest specific 8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Gas8 cDNA ORF clone
gRNAs
Gene Symbol | Gas8 |
Entrez Gene ID | 361438 |
Full Name | growth arrest specific 8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006255779.3 | XP_006255841.1 | growth arrest-specific protein 8 isoform X3 |
XM_008772637.2 | XP_008770859.1 | growth arrest-specific protein 8 isoform X6 |
XM_017601329.1 | XP_017456818.1 | growth arrest-specific protein 8 isoform X2 |
XM_008772635.2 | XP_008770857.1 | growth arrest-specific protein 8 isoform X4 |
XM_006255777.3 | XP_006255839.1 | growth arrest-specific protein 8 isoform X1 |
XM_008772636.2 | XP_008770858.1 | growth arrest-specific protein 8 isoform X5 |
NM_001039030.1 | NP_001034119.1 | dynein regulatory complex subunit 4 |
Danio rerio (zebrafish) | gas8 | NP_955928.1 |
Drosophila melanogaster (fruit fly) | Gas8 | NP_570065.2 |
Homo sapiens (human) | GAS8 | NP_001472.1 |
Canis lupus familiaris (dog) | GAS8 | XP_005620585.1 |
Mus musculus (house mouse) | Gas8 | NP_061343.2 |
Gallus gallus (chicken) | GAS8 | NP_001264546.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005850 | XP_001237728.2 |
Pan troglodytes (chimpanzee) | GAS8 | XP_511182.2 |
Xenopus tropicalis (tropical clawed frog) | gas8 | NP_001106441.1 |
GAS8 | XP_001093935.1 | |
Bos taurus (cattle) | GAS8 | NP_001091038.1 |
Rattus norvegicus (Norway rat) | Gas8 | NP_001034119.1 |
A mutation in
Abdelhamed Z, Vuong SM, Hill L, Shula C, Timms A, Beier D, Campbell K, Mangano FT, Stottmann RW, Goto J
Development (Cambridge, England)145(1)(2018 Jan)
Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.
Jeanson L, Thomas L, Copin B, Coste A, Sermet-Gaudelus I, Dastot-Le Moal F, Duquesnoy P, Montantin G, Collot N, Tissier S, Papon JF, Clement A, Louis B, Escudier E, Amselem S, Legendre M
Human mutation37(8)776-85(2016 08)
Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.
Lewis WR, Malarkey EB, Tritschler D, Bower R, Pasek RC, Porath JD, Birket SE, Saunier S, Antignac C, Knowles MR, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM, Hildebrandt F, Porter ME, Yoder BK, Berbari NF
PLoS genetics12(7)e1006220(2016 07)
Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex.
Olbrich H, Cremers C, Loges NT, Werner C, Nielsen KG, Marthin JK, Philipsen M, Wallmeier J, Pennekamp P, Menchen T, Edelbusch C, Dougherty GW, Schwartz O, Thiele H, Altm?ller J, Rommelmann F, Omran H
American journal of human genetics97(4)546-54(2015 Oct)
Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.
Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W, Caron MG
The Journal of biological chemistry286(31)27676-86(2011 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Gas8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gas8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa08405 | |
Clone ID Related Accession (Same CDS sequence) | NM_001039030.1 | |
Accession Version | NM_001039030.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-18 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | dynein regulatory complex subunit 4 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC099759.1. On Jan 12, 2006 this sequence version replaced XM_341716.2. ##Evidence-Data-START## Transcript exon combination :: BC099759.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCACCCA AAAGGAGAGG GAAGAAAGGG AAAGCCAAAG GGAATGCAGT CGTTGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001034119.1 |
CDS | 24..1460 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCACCCA AAAGGAGAGG GAAGAAAGGG AAAGCCAAAG GGAATGCAGT CGTTGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa47920 | |
Clone ID Related Accession (Same CDS sequence) | XM_008772636.2 | |
Accession Version | XM_008772636.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | growth arrest-specific protein 8 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772636.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGAAATG ACTTTGAAAG GCAAGTTCGA GAAATCGAGG CCAAATATGA TAAAAAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008770858.1 |
CDS | 114..1031 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCGAAATG ACTTTGAAAG GCAAGTTCGA GAAATCGAGG CCAAATATGA TAAAAAGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa39025 | |
Clone ID Related Accession (Same CDS sequence) | XM_006255777.3 | |
Accession Version | XM_006255777.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1356bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | growth arrest-specific protein 8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006255777.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGTGTGG TGGAGGAACA TGTCGCCCGC ATCCGGGAGG AGCTGGACCG GGAGCGGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006255839.1 |
CDS | 173..1528 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCGTGTGG TGGAGGAACA TGTCGCCCGC ATCCGGGAGG AGCTGGACCG GGAGCGGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa39027 | |
Clone ID Related Accession (Same CDS sequence) | XM_006255779.3 | |
Accession Version | XM_006255779.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | growth arrest-specific protein 8 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006255779.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCACCCA AAAGGAGAGG GAAGAAAGGG AAAGCCAAAG GGAATGCAGT CGTTGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006255841.1 |
CDS | 101..1252 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCACCCA AAAGGAGAGG GAAGAAAGGG AAAGCCAAAG GGAATGCAGT CGTTGATGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa47919 | |
Clone ID Related Accession (Same CDS sequence) | XM_008772635.2 | |
Accession Version | XM_008772635.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | growth arrest-specific protein 8 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772635.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTTTGA AAGGCAAGTT CGAGGTCAGT TTCGCAGACA TACACGGTGT AGGATGCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008770857.1 |
CDS | 122..1093 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACTTTGA AAGGCAAGTT CGAGGTCAGT TTCGCAGACA TACACGGTGT AGGATGCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa47921 | |
Clone ID Related Accession (Same CDS sequence) | XM_008772637.2 | |
Accession Version | XM_008772637.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | growth arrest-specific protein 8 isoform X6 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772637.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTTTGA AAGAAATCGA GGCCAAATAT GATAAAAAGA TGAAGATGCT TCGAGACGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008770859.1 |
CDS | 122..1021 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACTTTGA AAGAAATCGA GGCCAAATAT GATAAAAAGA TGAAGATGCT TCGAGACGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa59466 | |
Clone ID Related Accession (Same CDS sequence) | XM_017601329.1 | |
Accession Version | XM_017601329.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | growth arrest-specific protein 8 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGAGG CCGAGGAGAG GCACCAGGTG GAGATCAAGG TTTACAAGCA GAAAGTGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017456818.1 |
CDS | 393..1580 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGGAGG CCGAGGAGAG GCACCAGGTG GAGATCAAGG TTTACAAGCA GAAAGTGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A mutation in |
Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization. |
Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. |
Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. |
Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. |