Gene Symbol | Sirt2 |
Entrez Gene ID | 361532 |
Full Name | sirtuin 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Sirt2 cDNA ORF clone
Gene Symbol | Sirt2 |
Entrez Gene ID | 361532 |
Full Name | sirtuin 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006228675.2 | XP_006228737.1 | NAD-dependent protein deacetylase sirtuin-2 isoform X4 |
XM_006228672.3 | XP_006228734.1 | NAD-dependent protein deacetylase sirtuin-2 isoform X1 |
XM_006228676.3 | XP_006228738.1 | NAD-dependent protein deacetylase sirtuin-2 isoform X5 |
XM_006228673.3 | XP_006228735.1 | NAD-dependent protein deacetylase sirtuin-2 isoform X2 |
XM_017589353.1 | XP_017444842.1 | NAD-dependent protein deacetylase sirtuin-2 isoform X3 |
NM_001008368.1 | NP_001008369.1 | NAD-dependent protein deacetylase sirtuin-2 |
LOC100425019 | XP_002801273.1 | |
Drosophila melanogaster (fruit fly) | Sirt2 | NP_650880.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002943 | XP_311957.5 |
Schizosaccharomyces pombe (fission yeast) | hst2 | NP_588147.1 |
Pan troglodytes (chimpanzee) | SIRT2 | XP_001168375.1 |
Danio rerio (zebrafish) | sirt2 | NP_955890.1 |
Bos taurus (cattle) | SIRT2 | NP_001107003.1 |
Mus musculus (house mouse) | Sirt2 | NP_071877.3 |
Rattus norvegicus (Norway rat) | Sirt2 | NP_001008369.1 |
Canis lupus familiaris (dog) | SIRT2 | XP_855382.2 |
Kluyveromyces lactis | KLLA0F11033g | XP_455583.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_17827 | XP_003720356.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100489469 | XP_002935827.2 |
Homo sapiens (human) | SIRT2 | NP_036369.2 |
Gallus gallus (chicken) | SIRT2 | NP_001017414.1 |
Saccharomyces cerevisiae (baker's yeast) | HST2 | NP_015310.1 |
Eremothecium gossypii | AGOS_AGL018C | NP_986648.1 |
Neurospora crassa | NCU00523 | XP_963725.2 |
The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats.
Keskin-Aktan A, Akbulut KG, Yazici-Mutlu ?, Sonugur G, Ocal M, Akbulut H
Brain research bulletin137306-310(2018 Jan)
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.
Zhang Y, Chi D
Inflammation(2017 Dec)
MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2.
Zhao L, Qi Y, Xu L, Tao X, Han X, Yin L, Peng J
Redox biology15284-296(2017 Dec)
Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory.
Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY
Cell reports20(6)1335-1347(2017 Aug)
SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion.
Wang Y, Mu Y, Zhou X, Ji H, Gao X, Cai WW, Guan Q, Xu T
Apoptosis : an international journal on programmed cell death22(4)519-530(2017 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
study shows that SIRT2 regulates nuclear Nrf2 levels by modulating Akt phosphorylation, thus modulating the levels of GCL and total glutathione.
Title: SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells.
AGEs/AGEs receptor promote microtubule stabilization via the suppression of the SIRT2/acetylated alpha-tubulin signaling pathway in diabetic cardiomyopathy.
Title: SIRT2 regulates microtubule stabilization in diabetic cardiomyopathy.
Expression of endoplasmic reticulum stress associated CTRC mutants reduces the levels of acetylated tubulin by increasing both the levels and phosphorylation of the deacetylase SIRT2.
Title: ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation.
hippocampal SIRT2 is involved in the modulation of depressant-like behaviors, possibly by regulating neurogenesis.
Title: SIRT2 is involved in the modulation of depressive behaviors.
Our study helps to elucidate the mechanism for the participation of aging in Parkinson's disease (PD) and suggests that substantia nigra SIRT2 may be involved in PD neurodegeneration
Title: Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7.
The following Sirt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sirt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa11902 | |
Clone ID Related Accession (Same CDS sequence) | NM_001008368.1 | |
Accession Version | NM_001008368.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacetylase sirtuin-2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086545.1. On Dec 16, 2004 this sequence version replaced XM_341817.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086545.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGACTTCC TACGGAATTT ATTCACCCAG ACCCTGGGCC TGGGTTCCCA GAAGGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001008369.1 |
CDS | 467..1519 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001008368.1 |
1 | ATGGACTTCC TACGGAATTT ATTCACCCAG ACCCTGGGCC TGGGTTCCCA GAAGGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa22531 | |
Clone ID Related Accession (Same CDS sequence) | XM_006228672.3 | |
Accession Version | XM_006228672.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1470bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacetylase sirtuin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228672.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAAGCGG TTACGGGACC GCGTTGCCTG TCGGGAGTTG TATTTTTCTA TCCTCTCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006228734.1 |
CDS | 16..1485 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006228672.3 |
1 | ATGAAAGCGG TTACGGGACC GCGTTGCCTG TCGGGAGTTG TATTTTTCTA TCCTCTCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa22532 | |
Clone ID Related Accession (Same CDS sequence) | XM_006228673.3 | |
Accession Version | XM_006228673.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacetylase sirtuin-2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228673.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCGAGC CGGACCCCTC TGACCCTCTG GAGAACCAGG CAGGGAAGGT GCAGGAGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006228735.1 |
CDS | 103..1485 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006228673.3 |
1 | ATGGCCGAGC CGGACCCCTC TGACCCTCTG GAGAACCAGG CAGGGAAGGT GCAGGAGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa22534 | |
Clone ID Related Accession (Same CDS sequence) | XM_006228675.2 | |
Accession Version | XM_006228675.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacetylase sirtuin-2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228675.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAAGCGG TTACGGGACC GCGTTGCCTG TCGGGAGTTG TATTTTTCTA TCCTCTCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006228737.1 |
CDS | 16..1269 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006228675.2 |
1 | ATGAAAGCGG TTACGGGACC GCGTTGCCTG TCGGGAGTTG TATTTTTCTA TCCTCTCTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa22535 | |
Clone ID Related Accession (Same CDS sequence) | XM_006228676.3 | |
Accession Version | XM_006228676.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacetylase sirtuin-2 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228676.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCGAGC CGGACCCCTC TGACCCTCTG GAGAACCAGG CAGGGAAGGT GCAGGAGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006228738.1 |
CDS | 103..1269 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006228676.3 |
1 | ATGGCCGAGC CGGACCCCTC TGACCCTCTG GAGAACCAGG CAGGGAAGGT GCAGGAGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa56683 | |
Clone ID Related Accession (Same CDS sequence) | XM_017589353.1 | |
Accession Version | XM_017589353.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | NAD-dependent protein deacetylase sirtuin-2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACTTCC TACGGAATTT ATTCACCCAG ACCCTGGGCC TGGGTTCCCA GAAGGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017444842.1 |
CDS | 672..1943 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017589353.1 |
1 | ATGGACTTCC TACGGAATTT ATTCACCCAG ACCCTGGGCC TGGGTTCCCA GAAGGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats. |
Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B. |
MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2. |
Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. |
SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion. |