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Siva1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Siva1
Entrez Gene ID 362791
Full Name SIVA1, apoptosis-inducing factor
Synonyms Siva
General protein information
Preferred Names

SIVA1, apoptosis-inducing factor

Names

apoptosis regulatory protein Siva
CD27-binding protein
CD27BP
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

6

6q32

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006240645.3 XP_006240707.1 apoptosis regulatory protein Siva isoform X1
NM_001100982.1 NP_001094452.1 apoptosis regulatory protein Siva

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Siva1 NP_038957.2
Gallus gallus (chicken) SIVA1 NP_001264464.1
Bos taurus (cattle) SIVA1 NP_001180107.1
Rattus norvegicus (Norway rat) Siva1 NP_001094452.1
Danio rerio (zebrafish) siva1 XP_700568.6
Canis lupus familiaris (dog) SIVA1 XP_855513.1
Homo sapiens (human) SIVA1 NP_006418.2
Pan troglodytes (chimpanzee) SIVA1 XP_510197.3
SIVA1 XP_001095069.2
Xenopus tropicalis (tropical clawed frog) siva1 NP_001039138.1

Gene Ontology


Bibliography

Related articles in PubMed

Expression of apoptosis-inducing factor (AIF) in the aged rat brain.
Yu W, Gubkina O, Mechawar N, Elwell D, Quirion R, Krantic S
Neurobiology of aging32(1)179-80(2011 Jan)

The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.
Nestler M, Martin U, Hortschansky P, Saluz HP, Henke A, Munder T
Molecular and cellular biochemistry287(1-2)147-55(2006 Jul)

Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD).
Gudi R, Barkinge J, Hawkins S, Chu F, Manicassamy S, Sun Z, Duke-Cohan JS, Prasad KV
Oncogene25(24)3458-62(2006 Jun)

Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.
Py B, Slomianny C, Auberger P, Petit PX, Benichou S
Journal of immunology (Baltimore, Md. : 1950)172(7)4008-17(2004 Apr)

The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis.
Chu F, Borthakur A, Sun X, Barkinge J, Gudi R, Hawkins S, Prasad KV
Apoptosis : an international journal on programmed cell death9(1)83-95(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonistrated that AIF more abundantly expressed in striatum than in the other two brain regions.
Title: Expression of apoptosis-inducing factor (AIF) in the aged rat brain.

The following Siva1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Siva1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa00461 NM_001100982.1
Latest version!		 Rattus norvegicus SIVA1, apoptosis-inducing factor (Siva1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
ORa29675 XM_006240645.3
Latest version!		 Rattus norvegicus SIVA1, apoptosis-inducing factor (Siva1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa00461
Clone ID Related Accession (Same CDS sequence) NM_001100982.1
Accession Version NM_001100982.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 474bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-10-18
Organism Rattus norvegicus(Norway rat)
Product apoptosis regulatory protein Siva
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088866.1. On or before Aug 13, 2007 this sequence version replaced XM_343117.3, XM_001072396.1, XM_001072975.1. ##Evidence-Data-START## Transcript exon combination :: BC088866.1, CB775586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
ATGCCCAAGC GGAGCTGCCC GTTCACGGAT GCTGCCCCGC TTCAACTCAA AGTCCACGTG 
AGCCCGAGAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCGCGCGA GGTCTTCGAA 
AGAACCAAGC AGCTCCTTTT CCAAGGGGCC CAGGCCTATA GAGATCACAT CTGGGGTGAA 
GGTTGTTCCA TCAACCACCT GCCGGAGCCA CTCAAGCCTG GTCTGGTGGG AGCCCCTCAA 
GCTGCAAGGG GACAGATGTT GATTGGACCT GATGGCCGAC TGACACGGTG CCAAGCTCAG 
GCCTCGGAAG CTGGCCTTCC CGGGGCAGCA CCCATTGCTT GTTCATCCTG CGTGAGATCT 
GTGGATGGAA AGGCGGTCTG CAGCCAGTGT GAGCGGGCCC TGTGTGGGCA GTGTGTGTAC 
ACCTGCTGGG GCTGTGGTGC CTTGGCCTGT GTGCTGTGTG GCCTGGCAGA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001094452.1
CDS13..486
Translation

Target ORF information:

RefSeq Version NM_001100982.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus SIVA1, apoptosis-inducing factor (Siva1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001100982.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCCCAAGC GGAGCTGCCC GTTCACGGAT GCTGCCCCGC TTCAACTCAA AGTCCACGTG 
AGCCCGAGAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCGCGCGA GGTCTTCGAA 
AGAACCAAGC AGCTCCTTTT CCAAGGGGCC CAGGCCTATA GAGATCACAT CTGGGGTGAA 
GGTTGTTCCA TCAACCACCT GCCGGAGCCA CTCAAGCCTG GTCTGGTGGG AGCCCCTCAA 
GCTGCAAGGG GACAGATGTT GATTGGACCT GATGGCCGAC TGACACGGTG CCAAGCTCAG 
GCCTCGGAAG CTGGCCTTCC CGGGGCAGCA CCCATTGCTT GTTCATCCTG CGTGAGATCT 
GTGGATGGAA AGGCGGTCTG CAGCCAGTGT GAGCGGGCCC TGTGTGGGCA GTGTGTGTAC 
ACCTGCTGGG GCTGTGGTGC CTTGGCCTGT GTGCTGTGTG GCCTGGCAGA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa29675
Clone ID Related Accession (Same CDS sequence) XM_006240645.3
Accession Version XM_006240645.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 534bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product apoptosis regulatory protein Siva isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240645.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
ATGCCCAAGC GGAGCTGCCC GTTCACGGAT GCTGCCCCGC TTCAACTCAA AGTCCACGTG 
AGCCCGAGAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCGCGCGA GGTCTTCGAA 
AGAACCAAGC AGCTCCTTTT CCAAGGGGCC CAGGCCTATA GAGATCACAT CTGGGGTGAA 
GGTTGTTCCA TCAACCACCT GCCGGAGCCA CTCAAGCCTG GTCTGGTGGG AGCCCCTCAA 
GCTGCAAGGG GACAGATGTT GATTGGACCT GATGGCCGAC TGACACGGTG CCAAGCTCAG 
GCCTCGGAAG CTGGCCTTCC CGGGGCAGCA CCCATTGCTT GTTCATCCTG CGTGAGATCT 
GTGGATGGAA AGGCGGTCTG CAGCCAGTGT GAGCGGGCCC TGTGTGGGCA GTGTGTGTAC 
ACCTGCTGGG GCTGTGGTGC CTTGGCCTGT GTGCTGTGTG GCCTGGCAGA CTATGCCGAC 
GATGACGATG GTGAAAAGAC GCTTTGCACC AGCTGCGCCA TGTTTGAAGC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006240707.1
CDS135..668
Translation

Target ORF information:

RefSeq Version XM_006240645.3
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus SIVA1, apoptosis-inducing factor (Siva1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006240645.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGCCCAAGC GGAGCTGCCC GTTCACGGAT GCTGCCCCGC TTCAACTCAA AGTCCACGTG 
AGCCCGAGAG AGCTGAGCCA CGGTGTGTTC GCCGAGCGCT ACTCGCGCGA GGTCTTCGAA 
AGAACCAAGC AGCTCCTTTT CCAAGGGGCC CAGGCCTATA GAGATCACAT CTGGGGTGAA 
GGTTGTTCCA TCAACCACCT GCCGGAGCCA CTCAAGCCTG GTCTGGTGGG AGCCCCTCAA 
GCTGCAAGGG GACAGATGTT GATTGGACCT GATGGCCGAC TGACACGGTG CCAAGCTCAG 
GCCTCGGAAG CTGGCCTTCC CGGGGCAGCA CCCATTGCTT GTTCATCCTG CGTGAGATCT 
GTGGATGGAA AGGCGGTCTG CAGCCAGTGT GAGCGGGCCC TGTGTGGGCA GTGTGTGTAC 
ACCTGCTGGG GCTGTGGTGC CTTGGCCTGT GTGCTGTGTG GCCTGGCAGA CTATGCCGAC 
GATGACGATG GTGAAAAGAC GCTTTGCACC AGCTGCGCCA TGTTTGAAGC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Expression of apoptosis-inducing factor (AIF) in the aged rat brain.
Neurobiology of aging32(1)179-80(2011 Jan)
Yu W,Gubkina O,Mechawar N,Elwell D,Quirion R,Krantic S


book

The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.
Molecular and cellular biochemistry287(1-2)147-55(2006 Jul)
Nestler M,Martin U,Hortschansky P,Saluz HP,Henke A,Munder T


book

Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD).
Oncogene25(24)3458-62(2006 Jun)
Gudi R,Barkinge J,Hawkins S,Chu F,Manicassamy S,Sun Z,Duke-Cohan JS,Prasad KV


book

Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.
Journal of immunology (Baltimore, Md. : 1950)172(7)4008-17(2004 Apr)
Py B,Slomianny C,Auberger P,Petit PX,Benichou S


book

The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis.
Apoptosis : an international journal on programmed cell death9(1)83-95(2004 Jan)
Chu F,Borthakur A,Sun X,Barkinge J,Gudi R,Hawkins S,Prasad KV