Gene Symbol | Caln1 |
Entrez Gene ID | 363909 |
Full Name | calneuron 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Caln1 cDNA ORF clone
gRNAs
Gene Symbol | Caln1 |
Entrez Gene ID | 363909 |
Full Name | calneuron 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017598405.1 | XP_017453894.1 | calcium-binding protein 8 isoform X1 |
XM_006249243.3 | XP_006249305.1 | calcium-binding protein 8 isoform X3 |
XM_017598406.1 | XP_017453895.1 | calcium-binding protein 8 isoform X1 |
NM_001077201.1 | NP_001070669.1 | calcium-binding protein 8 |
XM_017598407.1 | XP_017453896.1 | calcium-binding protein 8 isoform X1 |
XM_017598408.1 | XP_017453897.1 | calcium-binding protein 8 isoform X2 |
XM_017598409.1 | XP_017453898.1 | calcium-binding protein 8 isoform X3 |
Gallus gallus (chicken) | CALN1 | XP_004946485.1 |
Homo sapiens (human) | CALN1 | NP_113656.2 |
LOC695315 | XP_001085472.2 | |
Bos taurus (cattle) | CALN1 | NP_001193044.1 |
Mus musculus (house mouse) | Caln1 | NP_851388.1 |
Danio rerio (zebrafish) | LOC562420 | XP_005157501.1 |
Rattus norvegicus (Norway rat) | Caln1 | NP_001070669.1 |
Xenopus tropicalis (tropical clawed frog) | caln1 | XP_002935846.1 |
Pan troglodytes (chimpanzee) | CALN1 | XP_001142591.1 |
Canis lupus familiaris (dog) | CALN1 | XP_005620990.1 |
Alternative splicing, expression and cellular localization of Calneuron-1 in the rat and human brain.
Hradsky J, Bernstein HG, Marunde M, Mikhaylova M, Kreutz MR
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society63(10)793-804(2015 10)
Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.
Hisamitsu T, Nakamura TY, Wakabayashi S
Molecular and cellular biology32(16)3265-80(2012 Aug)
Calneuron I inhibits Ca(2+) channel activity in bovine chromaffin cells.
Shih PY, Lin CL, Cheng PW, Liao JH, Pan CY
Biochemical and biophysical research communications388(3)549-53(2009 Oct)
Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking.
Mikhaylova M, Reddy PP, Munsch T, Landgraf P, Suman SK, Smalla KH, Gundelfinger ED, Sharma Y, Kreutz MR
Proceedings of the National Academy of Sciences of the United States of America106(22)9093-8(2009 Jun)
Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8.
McCue HV, Burgoyne RD, Haynes LP
Biochemical and biophysical research communications380(4)825-31(2009 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent.
Title: Alternative splicing, expression and cellular localization of Calneuron-1 in the rat and human brain.
NHE1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy
Title: Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.
These results suggest that CalnI attenuates Ca(2+) channel activity and that its subcellular localization is important for this effect.
Title: Calneuron I inhibits Ca(2+) channel activity in bovine chromaffin cells.
calneuron-1 and calneuron-2 physically associate with PI-4Kbeta, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking.
Title: Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking.
Calneurons have a different EF-hand organization than other calcium sensor proteins, are prominently expressed in neurons and will presumably bind Ca2+ with higher affinity than caldendrin.
Title: Neuronal Ca2+ signaling via caldendrin and calneurons.
The following Caln1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Caln1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa10319 | |
Clone ID Related Accession (Same CDS sequence) | NM_001077201.1 | |
Accession Version | NM_001077201.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-11-10 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcium-binding protein 8 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ914830.1. On or before Oct 14, 2006 this sequence version replaced XM_344102.3, XM_001071918.1. ##Evidence-Data-START## Transcript exon combination :: DQ914830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCGGCTGC CTGAGCAACC TGGAGATGGA AAGCCTGAGA ATGAGACAAA GGGGGACCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001070669.1 |
CDS | 1..786 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCGGCTGC CTGAGCAACC TGGAGATGGA AAGCCTGAGA ATGAGACAAA GGGGGACCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa34832 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249243.3 , XM_017598409.1 | |
Accession Version | XM_006249243.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcium-binding protein 8 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249243.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCGTTCC ACCATGTAAC TGCTGGCTTG TTGTACAAGG GGAATTACCT CAACCGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249305.1 |
CDS | 670..1329 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCGTTCC ACCATGTAAC TGCTGGCTTG TTGTACAAGG GGAATTACCT CAACCGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa34832 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249243.3 , XM_017598409.1 | |
Accession Version | XM_017598409.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcium-binding protein 8 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCGTTCC ACCATGTAAC TGCTGGCTTG TTGTACAAGG GGAATTACCT CAACCGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017453898.1 |
CDS | 19..678 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCGTTCC ACCATGTAAC TGCTGGCTTG TTGTACAAGG GGAATTACCT CAACCGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa57873 | |
Clone ID Related Accession (Same CDS sequence) | XM_017598405.1 , XM_017598406.1 , XM_017598407.1 | |
Accession Version | XM_017598405.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcium-binding protein 8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017453894.1 |
CDS | 577..1458 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa57873 | |
Clone ID Related Accession (Same CDS sequence) | XM_017598405.1 , XM_017598406.1 , XM_017598407.1 | |
Accession Version | XM_017598406.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcium-binding protein 8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017453895.1 |
CDS | 670..1551 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa57873 | |
Clone ID Related Accession (Same CDS sequence) | XM_017598405.1 , XM_017598406.1 , XM_017598407.1 | |
Accession Version | XM_017598407.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcium-binding protein 8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017453896.1 |
CDS | 709..1590 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa57874 | |
Clone ID Related Accession (Same CDS sequence) | XM_017598408.1 | |
Accession Version | XM_017598408.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | calcium-binding protein 8 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017453897.1 |
CDS | 577..1242 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTACCCCC AAATCTCTGA CCACATCACC CTGGACCCCC GATGCGGCTG CCTGAGCAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Alternative splicing, expression and cellular localization of Calneuron-1 in the rat and human brain. |
Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy. |
Calneuron I inhibits Ca(2+) channel activity in bovine chromaffin cells. |
Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking. |
Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. |