| Gene Symbol | Crb2 |
| Entrez Gene ID | 366031 |
| Full Name | crumbs 2, cell polarity complex component |
| Synonyms | RGD1309368 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
The following Crb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa13679 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001135761.1 | |
| Accession Version | NM_001135761.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3852bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-12-12 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | protein crumbs homolog 2 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07051797.1. On Oct 10, 2008 this sequence version replaced XM_345347.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCGCTGT TGGGGCCTGT GATCTGGGGC TTTAGACGAG ATGTCTACCT CCTGTTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001129233.1 |
| CDS | 1..3852 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001135761.1 |
1 | ATGGCGCTGT TGGGGCCTGT GATCTGGGGC TTTAGACGAG ATGTCTACCT CCTGTTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa25815 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006234103.3 | |
| Accession Version | XM_006234103.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3738bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | protein crumbs homolog 2 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234103.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGCGCTGT TGGGGCCTGT GATCTGGGGC TTTAGACGAG ATGTCTACCT CCTGTTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006234165.1 |
| CDS | 546..4283 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006234103.3 |
1 | ATGGCGCTGT TGGGGCCTGT GATCTGGGGC TTTAGACGAG ATGTCTACCT CCTGTTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. |
Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. |
Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa. |
Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. |
Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. |
