Edn3 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Edn3 |
| Entrez Gene ID | 366270 |
| Full Name | endothelin 3 |
| Synonyms | Et3,RGD1564825,preproET-3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001077650.1 | NP_001071118.1 | endothelin-3 precursor |
| Homo sapiens (human) | EDN3 | NP_996915.1 |
| Pan troglodytes (chimpanzee) | EDN3 | XP_525373.2 |
| Bos taurus (cattle) | EDN3 | NP_001095449.1 |
| Mus musculus (house mouse) | Edn3 | NP_031929.1 |
| Rattus norvegicus (Norway rat) | Edn3 | NP_001071118.1 |
| Canis lupus familiaris (dog) | EDN3 | NP_001002942.1 |
| Gallus gallus (chicken) | EDN3 | XP_001231488.3 |
Related articles in PubMed
Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor.
Sato A, Ebina K
Inflammation research : official journal of the European Histamine Research Society ... [et al.]62(4)417-24(2013 Apr)
Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis.
Rivera A, Kam SY, Ho M, Romero JR, Lee S
Blood cells, molecules & diseases50(2)80-5(2013 Feb)
A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors.
Gisser JM, Cohen AR, Yin H, Gariepy CE
PloS one8(9)e74311(2013)
Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways.
Evangelisti C, Bianco F, Pradella LM, Puliti A, Goldoni A, Sbrana I, Rossi M, Vargiolu M, Seri M, Romeo G, Stanghellini V, de Giorgio R, Bonora E
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society24(10)e497-508(2012 Oct)
Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel).
Zhu X, Rivera A, Golub MS, Peng J, Sha Q, Wu X, Song X, Kumarathasan P, Ho M, Redman CM, Lee S
American journal of hematology84(8)492-8(2009 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ET-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and nitric oxide production
Title: Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor.
A novel bidirectional interaction exists between endothelin-3 and retinoic acid in rat enteric nervous system precursors.
Title: A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors.
Present findings show a clear interaction between the endothelin system, and the catecholaminergic transmission in the olfactory bulb.
Title: Short-term effects of endothelins on tyrosine hydroxylase activity and expression in the olfactory bulb of normotensive rats.
Present results permit us to conclude that both endothelins play an important role in the regulation of norepinephrine neurotransmission at the presynaptic nerve endings in the hypothalamus.
Title: Regulation of the neuronal norepinephrine transporter by endothelin-1 and -3 in the rat anterior and posterior hypothalamus.
ET-3 significantly contributes to pulmonary vasoconstriction by activating the ET(B) at low concentration, and the ET(A) at high concentration.
Title: Endothelin-3-dependent pulmonary vasoconstriction in monocrotaline-induced pulmonary arterial hypertension.
The following Edn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Edn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa08280 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001077650.1 | |
| Accession Version | NM_001077650.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-04 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | endothelin-3 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S39779.1. On Nov 10, 2006 this sequence version replaced XM_001072605.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S39779.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGAGCTGG GGCTGTGGCT CCTTCTCGGG CTCACAGTGA CCTCCGCTGC AGCTGCACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001071118.1 |
| CDS | 172..675 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001077650.1 |
ORF Insert Sequence:
1 | ATGGAGCTGG GGCTGTGGCT CCTTCTCGGG CTCACAGTGA CCTCCGCTGC AGCTGCACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. |
|
Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis. |
|
A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors. |
|
Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. |
|
Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). |