Nanog cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Nanog
Entrez Gene ID	414065
Full Name	Nanog homeobox
General protein information	Preferred Names Nanog homeobox Names homeobox protein NANOG
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42

mRNA and Protein(s)

mRNA Protein Name

XM_006237310.2 XP_006237372.1 homeobox protein NANOG isoform X1

NM_001100781.1 NP_001094251.1 homeobox protein NANOG
Pathways from BioSystems

mRNA	Protein	Name
XM_006237310.2	XP_006237372.1	homeobox protein NANOG isoform X1
NM_001100781.1	NP_001094251.1	homeobox protein NANOG

Homologies

Canis lupus familiaris (dog)	NANOG	XP_005642482.1
Mus musculus (house mouse)	Nanog	NP_082292.1
Rattus norvegicus (Norway rat)	Nanog	NP_001094251.1
Pan troglodytes (chimpanzee)	NANOG	NP_001065295.1
	NANOG	XP_001112736.1
Homo sapiens (human)	NANOG	NP_079141.2
Bos taurus (cattle)	NANOG	NP_001020515.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network.
Festuccia N, Dubois A, Vandormael-Pournin S, Gallego Tejeda E, Mouren A, Bessonnard S, Mueller F, Proux C, Cohen-Tannoudji M, Navarro P
Nature cell biology18(11)1139-1148(2016 Nov)

Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury.
Gu J, Ni Y, Xu L, Xu H, Cai Z
Biochemical and biophysical research communications469(4)1097-103(2016 Jan)

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ
Proceedings of the National Academy of Sciences of the United States of America112(15)4666-71(2015 Apr)

Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos.
Wang C, Chen Y, Deng H, Gao S, Li L
Stem cells and development24(7)904-15(2015 Apr)

The expression analysis of nanog in the developing rat myocardial tissues.
Guo ZK, Guo K, Luo H, Mu LM, Li Q, Chang YQ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology35(3)866-74(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, these data suggested that both Nanog may play important roles in spinal cord pathophysiology via interact with CDK6.
Title: Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury.

Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model
Title: Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model.

The mRNA transcription and protein translation of nanog gene in the rat heart gradually decreased with every consecutive growth stage. This indicates that nanog gene has potential regulatory functions in the differentiation of myocardial cells
Title: The expression analysis of nanog in the developing rat myocardial tissues.

nanog-positive myocardial cells may respond to early myocardial repair, and the nanog-positive fibroblasts and small round cells are the main source for myocardial reconstruction after cardiac infarction
Title: Nanog expression in heart tissues induced by acute myocardial infarction.

Nanog and Klf4 antagonistically regulate c-Myc, and hence, cell hypoxia survival and cell cycle activation in experimental hepatoma.
Title: The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming.

The following Nanog gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nanog cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42285	NM_001100781.1 Latest version!	Rattus norvegicus Nanog homeobox (Nanog), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
ORa27736	XM_006237310.2 Latest version!	Rattus norvegicus Nanog homeobox (Nanog), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nanog ( NM_001100781.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094251.1 Rattus norvegicus Nanog homeobox (Nanog), mRNA.

Price & Availability↑

CloneID	ORa42285
Clone ID Related Accession (Same CDS sequence)	NM_001100781.1
Accession Version	NM_001100781.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	homeobox protein NANOG
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473964.2. On or before Sep 6, 2008 this sequence version replaced XM_575662.2, XM_001060618.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGAGCGTGG ATCTTTCTGG TCCCCACAGT CTGCCTAGTT GTGAGGAAGC ATCGAACTCT 
GGGGATTCCT CGCCGATGCC TGCCGTTCAT CTTCCTGAGG AAAATTATTC TTGCTTACAA 
GTGTCTGCTA CTGAGATGCT CTGCACAGAG ACTGCCTCTC CTCCGCCTTC CTCTGGGGAC 
CTACCTCTTC AAGATAGCCC TGATTCTTCT AGCAATCCCA AGCTAAAGCT GTCTGGTCCC 
GAGGCTGACG AGGGCCCTGA GAAGAAAGAA GAGAACAAGG TCCTCACCAA GAAGCAGAAG 
ATGCGGACTG TGTTCTCTCA GGCCCAGTTG TGTGCACTCA AGGATAGGTT TCAGAGGCAA 
AGGTACCTCA GCCTCCAGCA GATGCAAGAT CTCTCTACCA TTCTGAACCT GAGCTATAAG 
CAGGTGAAGA CCTGGTTCCA AAACCAAAGA ATGAAGTGCA AGAGGTGGCA GAAAAACCAA 
TGGTTGAAGA CTAGCAACGG CCTGACTCAG AAGGGCTCAG CGCCGGTGGA GTATCCCAGC 
ATCCATTGCA GCTATTCTCA GGGCTATCTG ATGAACGCGT CTGGAAACCT TCCAGTATGG 
GGCAGTCAGA CCTGGACCAA CCCAACTTGG AACAACCAGA CCTGGACCAA CCCAACCTGG 
AGCAACCAGA CCTGGACCAA CCCAACTTGG AGCAACCAGG CCTGGAGCAC TCAGTCCTGG 
TGTACTCAGG CCTGGAACAG CCAGACTTGG AACGCTGCTC CGCTCCATAA CTTCGGGGAG 
GACTCCCTGC AGCCTTATGT GCCGTTGCAG CAAAACTTCT CCGCCAGTGA TTTGGAGGCG 
AATTTGGAAG CCACTAGGGA AAGCCAGGCG CATTTTAGTA CCCCGCAAGC CTTGGAATTG 
TTCCTGAACT ACTCCGTGAA TTCTCCAGGC GAAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094251.1
CDS	204..1142
Translation	MSVDLSGPHSLPSCEEASNSGDSSPMPAVHLPEENYSCLQVSATEMLCTETASPPPSSGDLPLQDSPDSSSNPKLKLSGPEADEGPEKKEENKVLTKKQKMRTVFSQAQLCALKDRFQRQRYLSLQQMQDLSTILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLTQKGSAPVEYPSIHCSYSQGYLMNASGNLPVWGSQTWTNPTWNNQTWTNPTWSNQTWTNPTWSNQAWSTQSWCTQAWNSQTWNAAPLHNFGEDSLQPYVPLQQNFSASDLEANLEATRESQAHFSTPQALELFLNYSVNSPGEI

Target ORF information:

RefSeq Version	NM_001100781.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Nanog homeobox (Nanog), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100781.1

ORF Insert Sequence:

ATGAGCGTGG ATCTTTCTGG TCCCCACAGT CTGCCTAGTT GTGAGGAAGC ATCGAACTCT 
GGGGATTCCT CGCCGATGCC TGCCGTTCAT CTTCCTGAGG AAAATTATTC TTGCTTACAA 
GTGTCTGCTA CTGAGATGCT CTGCACAGAG ACTGCCTCTC CTCCGCCTTC CTCTGGGGAC 
CTACCTCTTC AAGATAGCCC TGATTCTTCT AGCAATCCCA AGCTAAAGCT GTCTGGTCCC 
GAGGCTGACG AGGGCCCTGA GAAGAAAGAA GAGAACAAGG TCCTCACCAA GAAGCAGAAG 
ATGCGGACTG TGTTCTCTCA GGCCCAGTTG TGTGCACTCA AGGATAGGTT TCAGAGGCAA 
AGGTACCTCA GCCTCCAGCA GATGCAAGAT CTCTCTACCA TTCTGAACCT GAGCTATAAG 
CAGGTGAAGA CCTGGTTCCA AAACCAAAGA ATGAAGTGCA AGAGGTGGCA GAAAAACCAA 
TGGTTGAAGA CTAGCAACGG CCTGACTCAG AAGGGCTCAG CGCCGGTGGA GTATCCCAGC 
ATCCATTGCA GCTATTCTCA GGGCTATCTG ATGAACGCGT CTGGAAACCT TCCAGTATGG 
GGCAGTCAGA CCTGGACCAA CCCAACTTGG AACAACCAGA CCTGGACCAA CCCAACCTGG 
AGCAACCAGA CCTGGACCAA CCCAACTTGG AGCAACCAGG CCTGGAGCAC TCAGTCCTGG 
TGTACTCAGG CCTGGAACAG CCAGACTTGG AACGCTGCTC CGCTCCATAA CTTCGGGGAG 
GACTCCCTGC AGCCTTATGT GCCGTTGCAG CAAAACTTCT CCGCCAGTGA TTTGGAGGCG 
AATTTGGAAG CCACTAGGGA AAGCCAGGCG CATTTTAGTA CCCCGCAAGC CTTGGAATTG 
TTCCTGAACT ACTCCGTGAA TTCTCCAGGC GAAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nanog ( XM_006237310.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237372.1 Rattus norvegicus Nanog homeobox (Nanog), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa27736
Clone ID Related Accession (Same CDS sequence)	XM_006237310.2
Accession Version	XM_006237310.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	homeobox protein NANOG isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006237310.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCGTGG ATCTTTCTGG TCCCCACAGT CTGCCTAGTT GTGAGGAAGC ATCGAACTCT 
GGGGATTCCT CGCCGATGCC TGCCGTTCAT CTTCCTGAGG AAAATTATTC TTGCTTACAA 
GTGTCTGCTA CTGAGATGCT CTGCACAGAG ACTGCCTCTC CTCCGCCTTC CTCTGGGGAC 
CTACCTCTTC AAGATAGCCC TGATTCTTCT AGCAATCCCA AGCTAAAGCT GTCTGGTCCC 
GAGGCTGACG AGGGCCCTGA GAAGAAAGAA GAGAACAAGG TCCTCACCAA GAAGCAGAAG 
ATGCGGACTG TGTTCTCTCA GGCCCAGTTG TGTGCACTCA AGGATAGGTT TCAGAGGCAA 
AGGTACCTCA GCCTCCAGCA GATGCAAGAT CTCTCTACCA TTCTGAACCT GAGCTATAAG 
CAGGTGAAGA CCTGGTTCCA AAACCAAAGA ATGAAGTGCA AGAGGTGGCA GAAAAACCAA 
TGGTTGAAGA CTAGCAACGG CCTGACTCAG GGCTCAGCGC CGGTGGAGTA TCCCAGCATC 
CATTGCAGCT ATTCTCAGGG CTATCTGATG AACGCGTCTG GAAACCTTCC AGTATGGGGC 
AGTCAGACCT GGACCAACCC AACTTGGAAC AACCAGACCT GGACCAACCC AACCTGGAGC 
AACCAGACCT GGACCAACCC AACTTGGAGC AACCAGGCCT GGAGCACTCA GTCCTGGTGT 
ACTCAGGCCT GGAACAGCCA GACTTGGAAC GCTGCTCCGC TCCATAACTT CGGGGAGGAC 
TCCCTGCAGC CTTATGTGCC GTTGCAGCAA AACTTCTCCG CCAGTGATTT GGAGGCGAAT 
TTGGAAGCCA CTAGGGAAAG CCAGGCGCAT TTTAGTACCC CGCAAGCCTT GGAATTGTTC 
CTGAACTACT CCGTGAATTC TCCAGGCGAA ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237372.1
CDS	1..936
Translation	MSVDLSGPHSLPSCEEASNSGDSSPMPAVHLPEENYSCLQVSATEMLCTETASPPPSSGDLPLQDSPDSSSNPKLKLSGPEADEGPEKKEENKVLTKKQKMRTVFSQAQLCALKDRFQRQRYLSLQQMQDLSTILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLTQGSAPVEYPSIHCSYSQGYLMNASGNLPVWGSQTWTNPTWNNQTWTNPTWSNQTWTNPTWSNQAWSTQSWCTQAWNSQTWNAAPLHNFGEDSLQPYVPLQQNFSASDLEANLEATRESQAHFSTPQALELFLNYSVNSPGEI

Target ORF information:

RefSeq Version	XM_006237310.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Nanog homeobox (Nanog), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237310.2

ORF Insert Sequence:

ATGAGCGTGG ATCTTTCTGG TCCCCACAGT CTGCCTAGTT GTGAGGAAGC ATCGAACTCT 
GGGGATTCCT CGCCGATGCC TGCCGTTCAT CTTCCTGAGG AAAATTATTC TTGCTTACAA 
GTGTCTGCTA CTGAGATGCT CTGCACAGAG ACTGCCTCTC CTCCGCCTTC CTCTGGGGAC 
CTACCTCTTC AAGATAGCCC TGATTCTTCT AGCAATCCCA AGCTAAAGCT GTCTGGTCCC 
GAGGCTGACG AGGGCCCTGA GAAGAAAGAA GAGAACAAGG TCCTCACCAA GAAGCAGAAG 
ATGCGGACTG TGTTCTCTCA GGCCCAGTTG TGTGCACTCA AGGATAGGTT TCAGAGGCAA 
AGGTACCTCA GCCTCCAGCA GATGCAAGAT CTCTCTACCA TTCTGAACCT GAGCTATAAG 
CAGGTGAAGA CCTGGTTCCA AAACCAAAGA ATGAAGTGCA AGAGGTGGCA GAAAAACCAA 
TGGTTGAAGA CTAGCAACGG CCTGACTCAG GGCTCAGCGC CGGTGGAGTA TCCCAGCATC 
CATTGCAGCT ATTCTCAGGG CTATCTGATG AACGCGTCTG GAAACCTTCC AGTATGGGGC 
AGTCAGACCT GGACCAACCC AACTTGGAAC AACCAGACCT GGACCAACCC AACCTGGAGC 
AACCAGACCT GGACCAACCC AACTTGGAGC AACCAGGCCT GGAGCACTCA GTCCTGGTGT 
ACTCAGGCCT GGAACAGCCA GACTTGGAAC GCTGCTCCGC TCCATAACTT CGGGGAGGAC 
TCCCTGCAGC CTTATGTGCC GTTGCAGCAA AACTTCTCCG CCAGTGATTT GGAGGCGAAT 
TTGGAAGCCA CTAGGGAAAG CCAGGCGCAT TTTAGTACCC CGCAAGCCTT GGAATTGTTC 
CTGAACTACT CCGTGAATTC TCCAGGCGAA ATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network.
Nature cell biology18(11)1139-1148(2016 Nov)
Festuccia N,Dubois A,Vandormael-Pournin S,Gallego Tejeda E,Mouren A,Bessonnard S,Mueller F,Proux C,Cohen-Tannoudji M,Navarro P

Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury.
Biochemical and biophysical research communications469(4)1097-103(2016 Jan)
Gu J,Ni Y,Xu L,Xu H,Cai Z

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America112(15)4666-71(2015 Apr)
Hayashi Y,Caboni L,Das D,Yumoto F,Clayton T,Deller MC,Nguyen P,Farr CL,Chiu HJ,Miller MD,Elsliger MA,Deacon AM,Godzik A,Lesley SA,Tomoda K,Conklin BR,Wilson IA,Yamanaka S,Fletterick RJ

Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos.
Stem cells and development24(7)904-15(2015 Apr)
Wang C,Chen Y,Deng H,Gao S,Li L

The expression analysis of nanog in the developing rat myocardial tissues.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology35(3)866-74(2015)
Guo ZK,Guo K,Luo H,Mu LM,Li Q,Chang YQ

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Nanog cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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