Gene Symbol | Sco1 |
Entrez Gene ID | 497930 |
Full Name | SCO1 cytochrome c oxidase assembly protein |
Synonyms | RGD1559538 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Sco1 cDNA ORF clone
gRNAs
Gene Symbol | Sco1 |
Entrez Gene ID | 497930 |
Full Name | SCO1 cytochrome c oxidase assembly protein |
Synonyms | RGD1559538 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001173374.1 | NP_001166845.1 | SCO cytochrome oxidase deficient homolog 1 |
Canis lupus familiaris (dog) | SCO1 | XP_546624.3 |
Bos taurus (cattle) | SCO1 | NP_001073712.1 |
Drosophila melanogaster (fruit fly) | Scox | NP_608884.1 |
Schizosaccharomyces pombe (fission yeast) | sco1 | NP_595287.1 |
Oryza sativa (rice) | Os02g0159700 | NP_001045964.1 |
Mus musculus (house mouse) | Sco1 | NP_001035115.1 |
Danio rerio (zebrafish) | LOC796572 | XP_005164365.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008774 | XP_314900.3 |
Caenorhabditis elegans (roundworm) | sco-1 | NP_494755.1 |
Saccharomyces cerevisiae (baker's yeast) | SCO1 | NP_009593.1 |
Homo sapiens (human) | SCO1 | NP_004580.1 |
Rattus norvegicus (Norway rat) | Sco1 | NP_001166845.1 |
Gallus gallus (chicken) | SCO1 | XP_004946120.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494754 | XP_002937049.2 |
LOC722074 | XP_001118271.1 | |
Magnaporthe oryzae (rice blast fungus) | MGG_03006 | XP_003720686.1 |
Neurospora crassa | NCU03177 | XP_964583.2 |
Arabidopsis thaliana (thale cress) | AT3G08950 | NP_566339.1 |
Pan troglodytes (chimpanzee) | SCO1 | XP_001164786.1 |
Kluyveromyces lactis | KLLA0D03630g | XP_453226.1 |
Eremothecium gossypii | AGOS_AEL191C | NP_984670.2 |
The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis.
Hlynialuk CJ, Ling B, Baker ZN, Cobine PA, Yu LD, Boulet A, Wai T, Hossain A, El Zawily AM, McFie PJ, Stone SJ, Diaz F, Moraes CT, Viswanathan D, Petris MJ, Leary SC
Cell reports(2015 Feb)
Mutations in COA6 cause cytochrome c oxidase deficiency and neonatal hypertrophic cardiomyopathy.
Baertling F, A M van den Brand M, Hertecant JL, Al-Shamsi A, P van den Heuvel L, Distelmaier F, Mayatepek E, Smeitink JA, Nijtmans LG, Rodenburg RJ
Human mutation36(1)34-8(2015 Jan)
Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.
Brosel S, Yang H, Tanji K, Bonilla E, Schon EA
The American journal of pathology177(5)2541-8(2010 Nov)
Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Yang H, Brosel S, Acin-Perez R, Slavkovich V, Nishino I, Khan R, Goldberg IJ, Graziano J, Manfredi G, Schon EA
Human molecular genetics19(1)170-80(2010 Jan)
Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.
Leary SC, Kaufman BA, Pellecchia G, Guercin GH, Mattman A, Jaksch M, Shoubridge EA
Human molecular genetics13(17)1839-48(2004 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Sco1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sco1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa06500 | |
Clone ID Related Accession (Same CDS sequence) | NM_001173374.1 | |
Accession Version | NM_001173374.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-19 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | SCO cytochrome oxidase deficient homolog 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK359925.1 and BC158882.1. On or before May 13, 2010 this sequence version replaced XM_001078805.2, XM_573117.3. ##Evidence-Data-START## Transcript exon combination :: BC158882.1, FQ209701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## |
1 | ATGGCGGCTC TTGTACGGTT AGCGGTGGTG CGTTCACAGT GTCGCCAGCT TTGGCATCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001166845.1 |
CDS | 38..892 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGCTC TTGTACGGTT AGCGGTGGTG CGTTCACAGT GTCGCCAGCT TTGGCATCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. |
Mutations in COA6 cause cytochrome c oxidase deficiency and neonatal hypertrophic cardiomyopathy. |
Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease. |
Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. |
Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase. |