Sco1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sco1
Entrez Gene ID	497930
Full Name	SCO1 cytochrome c oxidase assembly protein
Synonyms	RGD1559538
General protein information	Preferred Names SCO1 cytochrome c oxidase assembly protein Names SCO cytochrome oxidase deficient homolog 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24

mRNA and Protein(s)

mRNA	Protein	Name
NM_001173374.1	NP_001166845.1	SCO cytochrome oxidase deficient homolog 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SCO1	XP_546624.3
Bos taurus (cattle)	SCO1	NP_001073712.1
Drosophila melanogaster (fruit fly)	Scox	NP_608884.1
Schizosaccharomyces pombe (fission yeast)	sco1	NP_595287.1
Oryza sativa (rice)	Os02g0159700	NP_001045964.1
Mus musculus (house mouse)	Sco1	NP_001035115.1
Danio rerio (zebrafish)	LOC796572	XP_005164365.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008774	XP_314900.3
Caenorhabditis elegans (roundworm)	sco-1	NP_494755.1
Saccharomyces cerevisiae (baker's yeast)	SCO1	NP_009593.1
Homo sapiens (human)	SCO1	NP_004580.1
Rattus norvegicus (Norway rat)	Sco1	NP_001166845.1
Gallus gallus (chicken)	SCO1	XP_004946120.1
Xenopus tropicalis (tropical clawed frog)	LOC100494754	XP_002937049.2
	LOC722074	XP_001118271.1
Magnaporthe oryzae (rice blast fungus)	MGG_03006	XP_003720686.1
Neurospora crassa	NCU03177	XP_964583.2
Arabidopsis thaliana (thale cress)	AT3G08950	NP_566339.1
Pan troglodytes (chimpanzee)	SCO1	XP_001164786.1
Kluyveromyces lactis	KLLA0D03630g	XP_453226.1
Eremothecium gossypii	AGOS_AEL191C	NP_984670.2

Gene Ontology
Bibliography

Related articles in PubMed

The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis.
Hlynialuk CJ, Ling B, Baker ZN, Cobine PA, Yu LD, Boulet A, Wai T, Hossain A, El Zawily AM, McFie PJ, Stone SJ, Diaz F, Moraes CT, Viswanathan D, Petris MJ, Leary SC
Cell reports(2015 Feb)

Mutations in COA6 cause cytochrome c oxidase deficiency and neonatal hypertrophic cardiomyopathy.
Baertling F, A M van den Brand M, Hertecant JL, Al-Shamsi A, P van den Heuvel L, Distelmaier F, Mayatepek E, Smeitink JA, Nijtmans LG, Rodenburg RJ
Human mutation36(1)34-8(2015 Jan)

Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.
Brosel S, Yang H, Tanji K, Bonilla E, Schon EA
The American journal of pathology177(5)2541-8(2010 Nov)

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Yang H, Brosel S, Acin-Perez R, Slavkovich V, Nishino I, Khan R, Goldberg IJ, Graziano J, Manfredi G, Schon EA
Human molecular genetics19(1)170-80(2010 Jan)

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.
Leary SC, Kaufman BA, Pellecchia G, Guercin GH, Mattman A, Jaksch M, Shoubridge EA
Human molecular genetics13(17)1839-48(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sco1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sco1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06500	NM_001173374.1 Latest version!	Rattus norvegicus synthesis of cytochrome C oxidase 1 (Sco1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sco1 ( NM_001173374.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001166845.1 Rattus norvegicus synthesis of cytochrome C oxidase 1 (Sco1), mRNA.

Price & Availability↑

CloneID	ORa06500
Clone ID Related Accession (Same CDS sequence)	NM_001173374.1
Accession Version	NM_001173374.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Rattus norvegicus(Norway rat)
Product	SCO cytochrome oxidase deficient homolog 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK359925.1 and BC158882.1. On or before May 13, 2010 this sequence version replaced XM_001078805.2, XM_573117.3. ##Evidence-Data-START## Transcript exon combination :: BC158882.1, FQ209701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCGGCTC TTGTACGGTT AGCGGTGGTG CGTTCACAGT GTCGCCAGCT TTGGCATCTG 
TTCCCTCGCG GCCATGGGCT CAGGGGTATG GCGGAGAGGC CGAGACCGGA GGAGGCGCGC 
TGCTCCCTGG GGAGCCGAAA CTTCAGCGCC AGGCCGCCAC CGCCGGGTGC CGGGCCGGAG 
CCCAAGGGCA GTCAAGCGGG GTCTCACCGC CCGAAGCTTG GGCCTGTTTC TTGGAAGTCT 
TTAGCACTCA CTTTTGCCAT TGGAGGATCT TTATTGGCTG GAATGAAGTA CTTCAAGAAA 
GAGAAGATAG AAAAGCTGGA GAAACAGCGG CATCGCAGCA TTGGGAAGCC TTTACTAGGG 
GGACCATTTT CCCTCACAAC TCACAATGGA GAGCCCAAAA CTGACAAGGA CTTCCTGGGT 
CAATGGGTAT TGATTTATTT TGGCTTCACT CATTGCCCTG ATATCTGTCC AGAAGAACTG 
GAAAAAATGA TTGAAGTTGT GGAGGAAATA GACAGTATTC CATCCCTGCC AAATTTAACT 
CCACTTTTCA TCACCATTGA CCCAGAAAGG GACACAAAAG AAGCCATCGC AACTTATGTG 
AAAGAATTTT CTCCCAAATT GGTTGGTTTG ACTGGCACAA AGGAAGAGAT TGATGGAGTG 
GCCAGAGCAT ACAGGGTGTA TTACAGTCCT GGCCCTAAGG ACGAGGATGA GGACTACATA 
GTGGATCATA CAATAATAAT GTACTTGATT GGACCAGATG GAGAATTTCT TGATTATTTT 
GGACAAAACA AGAAGAAGGC AGAAATAGCT GGCTCAATAG CTGCACATAT GAGGTCACAC 
ATGAGGAAGA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166845.1
CDS	38..892
Translation	MAALVRLAVVRSQCRQLWHLFPRGHGLRGMAERPRPEEARCSLGSRNFSARPPPPGAGPEPKGSQAGSHRPKLGPVSWKSLALTFAIGGSLLAGMKYFKKEKIEKLEKQRHRSIGKPLLGGPFSLTTHNGEPKTDKDFLGQWVLIYFGFTHCPDICPEELEKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEIDGVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAHMRSHMRKR

Target ORF information:

RefSeq Version	NM_001173374.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synthesis of cytochrome C oxidase 1 (Sco1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173374.1

ORF Insert Sequence:

ATGGCGGCTC TTGTACGGTT AGCGGTGGTG CGTTCACAGT GTCGCCAGCT TTGGCATCTG 
TTCCCTCGCG GCCATGGGCT CAGGGGTATG GCGGAGAGGC CGAGACCGGA GGAGGCGCGC 
TGCTCCCTGG GGAGCCGAAA CTTCAGCGCC AGGCCGCCAC CGCCGGGTGC CGGGCCGGAG 
CCCAAGGGCA GTCAAGCGGG GTCTCACCGC CCGAAGCTTG GGCCTGTTTC TTGGAAGTCT 
TTAGCACTCA CTTTTGCCAT TGGAGGATCT TTATTGGCTG GAATGAAGTA CTTCAAGAAA 
GAGAAGATAG AAAAGCTGGA GAAACAGCGG CATCGCAGCA TTGGGAAGCC TTTACTAGGG 
GGACCATTTT CCCTCACAAC TCACAATGGA GAGCCCAAAA CTGACAAGGA CTTCCTGGGT 
CAATGGGTAT TGATTTATTT TGGCTTCACT CATTGCCCTG ATATCTGTCC AGAAGAACTG 
GAAAAAATGA TTGAAGTTGT GGAGGAAATA GACAGTATTC CATCCCTGCC AAATTTAACT 
CCACTTTTCA TCACCATTGA CCCAGAAAGG GACACAAAAG AAGCCATCGC AACTTATGTG 
AAAGAATTTT CTCCCAAATT GGTTGGTTTG ACTGGCACAA AGGAAGAGAT TGATGGAGTG 
GCCAGAGCAT ACAGGGTGTA TTACAGTCCT GGCCCTAAGG ACGAGGATGA GGACTACATA 
GTGGATCATA CAATAATAAT GTACTTGATT GGACCAGATG GAGAATTTCT TGATTATTTT 
GGACAAAACA AGAAGAAGGC AGAAATAGCT GGCTCAATAG CTGCACATAT GAGGTCACAC 
ATGAGGAAGA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis.
Cell reports(2015 Feb)
Hlynialuk CJ,Ling B,Baker ZN,Cobine PA,Yu LD,Boulet A,Wai T,Hossain A,El Zawily AM,McFie PJ,Stone SJ,Diaz F,Moraes CT,Viswanathan D,Petris MJ,Leary SC

Mutations in COA6 cause cytochrome c oxidase deficiency and neonatal hypertrophic cardiomyopathy.
Human mutation36(1)34-8(2015 Jan)
Baertling F,A M van den Brand M,Hertecant JL,Al-Shamsi A,P van den Heuvel L,Distelmaier F,Mayatepek E,Smeitink JA,Nijtmans LG,Rodenburg RJ

Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.
The American journal of pathology177(5)2541-8(2010 Nov)
Brosel S,Yang H,Tanji K,Bonilla E,Schon EA

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Human molecular genetics19(1)170-80(2010 Jan)
Yang H,Brosel S,Acin-Perez R,Slavkovich V,Nishino I,Khan R,Goldberg IJ,Graziano J,Manfredi G,Schon EA

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.
Human molecular genetics13(17)1839-48(2004 Sep)
Leary SC,Kaufman BA,Pellecchia G,Guercin GH,Mattman A,Jaksch M,Shoubridge EA

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Sco1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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