Gene Symbol | Fxn |
Entrez Gene ID | 499335 |
Full Name | frataxin |
Synonyms | RGD1565754 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Fxn cDNA ORF clone
Gene Symbol | Fxn |
Entrez Gene ID | 499335 |
Full Name | frataxin |
Synonyms | RGD1565754 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001191952.1 | NP_001178881.1 | frataxin, mitochondrial |
Bos taurus (cattle) | FXN | NP_001074196.1 |
Gallus gallus (chicken) | FXN | XP_424827.3 |
Homo sapiens (human) | FXN | NP_000135.2 |
Pan troglodytes (chimpanzee) | FXN | XP_001137864.2 |
Danio rerio (zebrafish) | fxn | NP_001076485.1 |
Arabidopsis thaliana (thale cress) | FH | NP_192233.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100497789 | XP_004910856.1 |
FXN | XP_001093449.1 | |
Mus musculus (house mouse) | Fxn | NP_032070.1 |
Rattus norvegicus (Norway rat) | Fxn | NP_001178881.1 |
Canis lupus familiaris (dog) | FXN | NP_001103428.1 |
Oryza sativa (rice) | Os01g0783600 | NP_001044455.2 |
Dual role of the mitochondrial protein frataxin in astrocytic tumors.
Kirches E, Andrae N, Hoefer A, Kehler B, Zarse K, Leverkus M, Keilhoff G, Schonfeld P, Schneider T, Wilisch-Neumann A, Mawrin C
Laboratory investigation; a journal of technical methods and pathology91(12)1766-76(2011 Dec)
Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.
Melli G, Taiana M, Camozzi F, Triolo D, Podini P, Quattrini A, Taroni F, Lauria G
Experimental neurology214(2)276-84(2008 Dec)
Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity.
Pomplun D, Voigt A, Schulz TJ, Thierbach R, Pfeiffer AF, Ristow M
Proceedings of the National Academy of Sciences of the United States of America104(15)6377-81(2007 Apr)
Iron-sulfur protein maturation in human cells: evidence for a function of frataxin.
Stehling O, Els?sser HP, Br?ckel B, M?hlenhoff U, Lill R
Human molecular genetics13(23)3007-15(2004 Dec)
Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity.
Bulteau AL, O'Neill HA, Kennedy MC, Ikeda-Saito M, Isaya G, Szweda LI
Science (New York, N.Y.)305(5681)242-5(2004 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
frataxin deficiency in neonatal rat ventricular myocytes leads to mitochondrial dysfunction and oxidative stress, which would affect lipid metabolism.
Title: Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism.
Frataxin depletion caused mitochondrial membrane potential decrease, neurite degeneration and apoptotic cell death.
Title: Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein.
dual, pro-proliferative but chemosensitizing role in astrocytic tumors
Title: Dual role of the mitochondrial protein frataxin in astrocytic tumors.
The following Fxn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fxn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa39886 | |
Clone ID Related Accession (Same CDS sequence) | NM_001191952.1 | |
Accession Version | NM_001191952.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2012-04-28 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | frataxin, mitochondrial | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR03006217.1, AABR03005338.1 and AABR03009513.1. On Jul 17, 2010 this sequence version replaced XM_574642.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. |
1 | ATGTGGACGT TCGGACGCCG CGCAGCCGCG GGCTTGCTGC CCCGGACGGC CTCCCGGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001178881.1 |
CDS | 1..621 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001191952.1 |
1 | ATGTGGACGT TCGGACGCCG CGCAGCCGCG GGCTTGCTGC CCCGGACGGC CTCCCGGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Dual role of the mitochondrial protein frataxin in astrocytic tumors. |
Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. |
Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. |
Iron-sulfur protein maturation in human cells: evidence for a function of frataxin. |
Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity. |