Gene Symbol | Aak1 |
Entrez Gene ID | 500244 |
Full Name | AP2 associated kinase 1 |
Synonyms | RGD1563580 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Aak1 cDNA ORF clone
gRNAs
Gene Symbol | Aak1 |
Entrez Gene ID | 500244 |
Full Name | AP2 associated kinase 1 |
Synonyms | RGD1563580 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017592821.1 | XP_017448310.1 | AP2-associated protein kinase 1 isoform X4 |
XM_017592822.1 | XP_017448311.1 | AP2-associated protein kinase 1 isoform X5 |
XM_006236833.3 | XP_006236895.1 | AP2-associated protein kinase 1 isoform X6 |
NM_001173450.1 | NP_001166921.1 | AP2-associated protein kinase 1 |
XM_017592818.1 | XP_017448307.1 | AP2-associated protein kinase 1 isoform X1 |
XM_006236834.3 | XP_006236896.1 | AP2-associated protein kinase 1 isoform X7 |
XM_017592819.1 | XP_017448308.1 | AP2-associated protein kinase 1 isoform X2 |
XM_017592817.1 | XP_017448306.1 | AP2-associated protein kinase 1 isoform X1 |
XM_017592820.1 | XP_017448309.1 | AP2-associated protein kinase 1 isoform X3 |
Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN
Neuron73(6)1127-42(2012 Mar)
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ
Chemistry & biology18(7)891-906(2011 Jul)
The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.
Gupta-Rossi N, Ortica S, Meas-Yedid V, Heuss S, Moretti J, Olivo-Marin JC, Isra?l A
The Journal of biological chemistry286(21)18720-30(2011 May)
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis.
Sorensen EB, Conner SD
Traffic (Copenhagen, Denmark)9(10)1791-800(2008 Sep)
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.
Henderson DM, Conner SD
Molecular biology of the cell18(7)2698-706(2007 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study demonistrated that AAK1 contributes to dendrite growth regulation.
Title: Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
AAK1 is a relevant target of K252a, that the loss of AAK1 alters ErbB4 trafficking and expression levels, providing evidence for a previously unrecognized role for AAK1 in Nrg1-mediated neurotrophic factor signaling.
Title: AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
The following Aak1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aak1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa06561 | |
Clone ID Related Accession (Same CDS sequence) | XM_006236833.3 , NM_001173450.1 | |
Accession Version | NM_001173450.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2892bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC112554.5, AABR07073039.1 and AABR07061355.1. On or before May 13, 2010 this sequence version replaced XM_575594.3, XM_001070331.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001166921.1 |
CDS | 537..3428 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa06561 | |
Clone ID Related Accession (Same CDS sequence) | XM_006236833.3 , NM_001173450.1 | |
Accession Version | XM_006236833.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2892bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X6 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236833.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006236895.1 |
CDS | 382..3273 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa27438 | |
Clone ID Related Accession (Same CDS sequence) | XM_006236834.3 | |
Accession Version | XM_006236834.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2889bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X7 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236834.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006236896.1 |
CDS | 382..3270 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa60976 | |
Clone ID Related Accession (Same CDS sequence) | XM_017592818.1 , XM_017592817.1 | |
Accession Version | XM_017592818.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017448307.1 |
CDS | 2044..5964 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa60976 | |
Clone ID Related Accession (Same CDS sequence) | XM_017592818.1 , XM_017592817.1 | |
Accession Version | XM_017592817.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017448306.1 |
CDS | 383..4303 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa60977 | |
Clone ID Related Accession (Same CDS sequence) | XM_017592819.1 | |
Accession Version | XM_017592819.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3918bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017448308.1 |
CDS | 383..4300 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa60978 | |
Clone ID Related Accession (Same CDS sequence) | XM_017592820.1 | |
Accession Version | XM_017592820.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3699bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017448309.1 |
CDS | 382..4080 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa60979 | |
Clone ID Related Accession (Same CDS sequence) | XM_017592821.1 | |
Accession Version | XM_017592821.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3495bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017448310.1 |
CDS | 382..3876 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa60980 | |
Clone ID Related Accession (Same CDS sequence) | XM_017592822.1 | |
Accession Version | XM_017592822.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3399bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | AP2-associated protein kinase 1 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017448311.1 |
CDS | 382..3780 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. |
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. |
The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. |
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis. |
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. |