Acox1 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Acox1 |
| Entrez Gene ID | 50681 |
| Full Name | acyl-CoA oxidase 1 |
| Synonyms | RATACOA1,aCoA |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | catalyzes the oxidation of fatty acyl CoA to trans-2-enoyl-CoA and peroxide [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_017340.2 | NP_059036.1 | peroxisomal acyl-coenzyme A oxidase 1 |
| ACOX1 | XP_001102134.1 | |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011798 | XP_320718.4 |
| Caenorhabditis elegans (roundworm) | F08A8.3 | NP_493263.1 |
| Arabidopsis thaliana (thale cress) | ACX5 | NP_181112.1 |
| Bos taurus (cattle) | ACOX1 | NP_001030366.1 |
| Mus musculus (house mouse) | Acox1 | NP_056544.2 |
| Rattus norvegicus (Norway rat) | Acox1 | NP_059036.1 |
| Caenorhabditis elegans (roundworm) | F59F4.1 | NP_510603.1 |
| Arabidopsis thaliana (thale cress) | ACX1 | NP_567513.4 |
| Homo sapiens (human) | ACOX1 | NP_009223.2 |
| Pan troglodytes (chimpanzee) | ACOX1 | XP_001149084.1 |
| Gallus gallus (chicken) | ACOX1 | NP_001006205.1 |
| Oryza sativa (rice) | Os06g0103500 | NP_001056542.1 |
| Canis lupus familiaris (dog) | ACOX1 | XP_003435209.1 |
| Caenorhabditis elegans (roundworm) | acox-1 | NP_001021089.1 |
| Danio rerio (zebrafish) | acox1 | NP_001005933.1 |
| Drosophila melanogaster (fruit fly) | CG5009 | NP_611264.2 |
| Caenorhabditis elegans (roundworm) | F08A8.2 | NP_493262.2 |
| Caenorhabditis elegans (roundworm) | F08A8.4 | NP_493264.1 |
| Caenorhabditis elegans (roundworm) | C48B4.1 | NP_499119.1 |
| Xenopus tropicalis (tropical clawed frog) | acox1 | NP_001015762.1 |
Related articles in PubMed
Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet.
Zeng J, Deng S, Wang Y, Li P, Tang L, Pang Y
The Journal of biological chemistry292(9)3800-3809(2017 03)
Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
Sang?esa G, Shaligram S, Akther F, Roglans N, Laguna JC, Rahimian R, Alegret M
American journal of physiology. Heart and circulatory physiology312(2)H289-H304(2017 Feb)
Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine.
Bonfleur ML, Borck PC, Ribeiro RA, Caetano LC, Soares GM, Carneiro EM, Balbo SL
Life sciences13515-21(2015 Aug)
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Th?riault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S
The Journal of cell biology199(6)951-67(2012 Dec)
Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].
Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, Khan M, Huang J, Guo D, Yu S, Sarkar J, Singh I, Rao MS, Wanders RJ, Reddy JK, Cherkaoui-Malki M
Laboratory investigation; a journal of technical methods and pathology90(5)696-708(2010 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Inhibition of ACOX1 is a novel and effective approach for the treatment of high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism
Title: Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet.
Tau supplementation prevented obesity and hepatic TG deposition by upregulating MTP mRNA, ameliorating hepatic lipid efflux, and consequently enhancing PPAR-alpha which increases lipid oxidation through ACO and CPT-1a gene expressions.
Title: Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine.
In comparison with the control group, while ACO mRNA was markedly decreased in the obese group.
Title: [Study on SOCS-3, PPARgamma and ACO mRNA expression of adipose tissues in obese rats with leptin resistance].
The isomerase activity of the enzyme was characterized through studies of kinetics, pH dependence, and enzyme inhibition.
Title: Intrinsic enoyl-CoA isomerase activity of rat acyl-CoA oxidase I.
The following Acox1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acox1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa03693 | |
| Clone ID Related Accession (Same CDS sequence) | NM_017340.2 | |
| Accession Version | NM_017340.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1986bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | peroxisomal acyl-coenzyme A oxidase 1 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085743.1. On Jun 10, 2007 this sequence version replaced NM_017340.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085743.1, J02752.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGAACCCCG ACCTGCGCAA GGAGCGGGCC TCCGCCACCT TCAATCCGGA GTTGATCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_059036.1 |
| CDS | 91..2076 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_017340.2 |
ORF Insert Sequence:
1 | ATGAACCCCG ACCTGCGCAA GGAGCGGGCC TCCGCCACCT TCAATCCGGA GTTGATCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet. |
|
Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats. |
|
Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine. |
|
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. |
|
Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. |