Tgm2 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Tgm2 |
| Entrez Gene ID | 56083 |
| Full Name | transglutaminase 2 |
| Synonyms | TgaseII |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | catalyzes acyl transferase reaction of gamma-carboxamide groups of glutamine residues (donor peptide) with epsilon-amino groups of lysine residues (acceptor peptide) [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_019386.2 | NP_062259.2 | protein-glutamine gamma-glutamyltransferase 2 |
| Pan troglodytes (chimpanzee) | TGM2 | XP_001144553.2 |
| Canis lupus familiaris (dog) | TGM2 | XP_542991.4 |
| Gallus gallus (chicken) | TGM2 | NP_990779.1 |
| Danio rerio (zebrafish) | tgm2b | NP_997821.2 |
| Homo sapiens (human) | TGM2 | NP_004604.2 |
| Bos taurus (cattle) | TGM2 | NP_803473.1 |
| Rattus norvegicus (Norway rat) | Tgm2 | NP_062259.2 |
| Xenopus tropicalis (tropical clawed frog) | tgm2 | NP_001123852.1 |
| Mus musculus (house mouse) | Tgm2 | NP_033399.1 |
Related articles in PubMed
Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability.
Yunes-Medina L, Paciorkowski A, Nuzbrokh Y, Johnson GVW
Molecular and cellular neurosciences8672-80(2018 Jan)
Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures.
Espitia Pinz?n N, Brev? JJP, Bol JGJM, Drukarch B, Baron W, van Dam AM
Journal of neuroinflammation14(1)260(2017 Dec)
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Vyas FS, Nelson CP, Freeman F, Boocock DJ, Hargreaves AJ, Dickenson JM
European journal of pharmacology813105-121(2017 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
An increase in TG2 activity contributes to age-associated increase in diastolic stiffness, thereby facilitating age-associated diastolic dysfunction.
Title: Role of tissue transglutaminase in age-associated ventricular stiffness.
our findings suggest that cystamine induced vasodilatation in rat mesenteric small arteries by inhibition of receptor-coupled TG2, leading to opening of Kv channels and reduction of intracellular calcium as well as activation of a pathway sensitive to inhibitors of the mitochondrial complexes I and III
Title: Involvement of transglutaminase 2 and voltage-gated potassium channels in cystamine vasodilatation in rat mesenteric small arteries.
Expression, activity, and functionality of TG1 and TG2 are decreased in the aorta, but not in the vena cava, from hypertensive rats.
Title: Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.
a pleiotropic enzyme transglutaminase type 2 targets the allosteric coupling domain of IP3R type 1 (IP3R1) and negatively regulates IP3R1-mediated calcium signaling and autophagy by locking the subunit configurations.
Title: Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.
Chronic allograft nephropathy was associated with upregulation of renal TG2 pathway.
Title: Upregulation of transglutaminase and ? (?-glutamyl)-lysine in the Fisher-Lewis rat model of chronic allograft nephropathy.
The following Tgm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tgm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa13801 | |
| Clone ID Related Accession (Same CDS sequence) | NM_019386.2 | |
| Accession Version | NM_019386.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-11-18 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | protein-glutamine gamma-glutamyltransferase 2 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC062062.1. On Feb 9, 2004 this sequence version replaced NM_019386.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062062.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGGCCGAGG AGCTGAACCT GGAGAGGTGC GATTTGGAGA TACAGGCCAA TGGCCGTGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_062259.2 |
| CDS | 57..2117 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_019386.2 |
ORF Insert Sequence:
1 | ATGGCCGAGG AGCTGAACCT GGAGAGGTGC GATTTGGAGA TACAGGCCAA TGGCCGTGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability. |
|
Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures. |
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