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NTRK1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene Symbol NTRK1
Entrez Gene ID 59109
Full Name neurotrophic receptor tyrosine kinase 1
Synonyms Trk
General protein information
Preferred Names

neurotrophic receptor tyrosine kinase 1

Names

high affinity nerve growth factor receptor
TrkA neurotrophin receptor
neurotrophic tyrosine kinase, receptor, type 1
p140-TrkA
slow nerve growth factor receptor
trk
trk-A
trkA proto-oncogene receptor
tropomyosin-related kinase A

Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

2

2q34

Summary a protooncogene; receptor that binds to nerve growth factor (NGF) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA Protein Name
NM_021589.1 NP_067600.1 high affinity nerve growth factor receptor precursor



Xenopus tropicalis (tropical clawed frog) ntrk1 XP_002939035.1
Macaca mulatta (rhesus monkey) NTRK1 XP_001114243.2
Pan troglodytes (chimpanzee) NTRK1 XP_003308563.1
Mus musculus (house mouse) Ntrk1 NP_001028296.1
Canis lupus familiaris (dog) NTRK1 XP_851619.3
Rattus norvegicus (Norway rat) Ntrk1 NP_067600.1
Homo sapiens (human) NTRK1 NP_002520.2
Bos taurus (cattle) NTRK1 XP_002686012.2
Gallus gallus (chicken) NTRK1 NP_990709.1
Danio rerio (zebrafish) ntrk1 XP_697246.5


Related articles in PubMed

[Effects of ischemia on the expression of neurotrophins and their receptors in rat brain structures outside the lesion site, including on the opposite hemisphere].
Dmitrieva VG, Stavchansky VV, Povarova OV, Skvortsova VI, Limborska SA, Dergunova LV
Molekuliarnaia biologiia50(5)775-784(2016 Sep-Oct)

Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Gudasheva TA, Povarnina PY, Antipova TA, Firsova YN, Konstantinopolsky MA, Seredenin SB
Journal of biomedical science22106(2015 Dec)

The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells.
Ceriani M, Amigoni L, D'Aloia A, Berruti G, Martegani E
Experimental cell research333(1)49-59(2015 Apr)

RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.
Tam SY, Lilla JN, Chen CC, Kalesnikoff J, Tsai M
PloS one10(11)e0142935(2015)

Overexpression of NTRK1 Promotes Differentiation of Neural Stem Cells into Cholinergic Neurons.
Wang L, He F, Zhong Z, Lv R, Xiao S, Liu Z
BioMed research international2015857202(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation
Title: The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.

USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

It has been shown that ischemia influenced the expression of neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA, TrkC, p75) in brain structures outside the lesion focus, including the contralateral hemisphere.
Title: [Effects of ischemia on the expression of neurotrophins and their receptors in rat brain structures outside the lesion site, including on the opposite hemisphere].

Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Title: Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.

Our data suggest that RabGEF1 is a negative regulator of TrkA-dependent neuronal differentiation and of NMDA receptor-mediated signaling activation in NGF-differentiated PC12 cells.
Title: RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.

The following NTRK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NTRK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
ORa13402 NM_021589.1
Latest version!
Rattus norvegicus neurotrophic receptor tyrosine kinase 1 (Ntrk1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $391.30
$559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID ORa13402
Clone ID Related Accession (Same CDS sequence) NM_021589.1
Accession Version NM_021589.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2400bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Rattus norvegicus(Norway rat)
Product high affinity nerve growth factor receptor precursor
Comment PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M85214.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M85214.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGCTGCGAG GCCAGCGGCA CGGGCAGCTG GGTTGGCATC GCCCGGCCGC GGGGCTAGGC 
GGTCTGGTGA CTTCGTTGAT GCTGGCTTGT GCTTGCGCCG CATCCTGTCG TGAGACCTGC
TGTCCCGTGG GCCCCTCGGG GTTGCGCTGC ACCAGGGCAG GGACCCTGAA TACCCTCCGC
GGCCTGCGGG GCGCCGGGAA CCTGACGGAG CTCTATGTGG AAAACCAGCG GGATCTGCAA
CGCCTGGAGT TTGAGGACCT GCAGGGCCTG GGGGAGTTGA GAAGCCTAAC CATCGTGAAG
AGTGGCCTCC GCTTTGTGGC CCCTGATGCC TTCCATTTCA CCCCTCGGCT CAGTCACCTG
AATCTCTCCT CCAATGCTTT GGAGTCCCTC TCCTGGAAAA CTGTGCAGGG CCTCTCCCTA
CAGGACTTGA CCCTGTCAGG GAACCCACTG CACTGTTCCT GTGCCCTATT GTGGCTCCAG
CGCTGGGAGC AGGAGGATTT GTGTGGTGTG TATACACAAA AGCTTCAGGG CTCTGGGTCT
GGAGACCAGT TCCTCCCACT GGGACACAAC AACAGTTGTG GTGTACCCTC AGTGAAGATC
CAGATGCCCA ATGACTCTGT GGAAGTGGGG GATGACGTTT TTCTGCAGTG CCAGGTGGAG
GGGCAGGCCC TACAGCAGGC TGACTGGATC CTCACAGAGC TGGAAGGGAC AGCCACCATG
AAGAAATCTG GAGATCTGCC ATCCCTGGGG CTAACTCTGG TCAATGTCAC CAGTGATCTC
AACAAGAAGA ATGTGACGTG CTGGGCAGAG AATGATGTGG GCCGGGCTGA GGTCTCTGTC
CAAGTCAGCG TCTCCTTCCC AGCCAGTGTG CATCTGGGCA AAGCCGTGGA ACAGCATCAC
TGGTGCATTC CCTTCTCTGT GGACGGGCAG CCAGCACCGT CCCTGCGCTG GTTCTTCAAC
GGCTCTGTGC TCAATGAGAC CAGCTTCATC TTCACTCAGT TCTTGGAGTC AGCGCTGACC
AATGAGACCA TGCGGCATGG CTGCCTTCGC CTCAACCAGC CCACGCATGT CAACAACGGG
AACTACACCC TGCTGGCTGC CAACCCCTAT GGCCAGGCTG CTGCCTCCAT CATGGCTGCC
TTTATGGACA ACCCTTTTGA GTTCAACCCT GAGGACCCCA TCCCTGTCTC CTTCTCGCCA
GTGGACACTA ACAGCACATC AAGAGACCCA GTGGAGAAGA AGGACGAAAC ACCTTTTGGG
GTCTCTGTGG CTGTGGGCCT GGCCGTCTCC GCCGCCCTCT TCCTTTCTGC CCTCCTCCTA
GTGCTCAACA AATGTGGACA GAGGAGCAAA TTTGGGATCA ACCGCCCTGC TGTGCTGGCG
CCAGAGGATG GGCTGGCCAT GTCCCTACAC TTCATGACAC TGGGTGGCAG TTCTCTTTCC
CCTACTGAGG GCAAAGGCTC CGGACTCCAG GGCCACATCA TGGAGAACCC ACAGTACTTC
AGTGATACCT GTGTCCACCA TATCAAGCGC CAGGACATCA TTCTCAAGTG GGAGCTAGGG
GAGGGAGCCT TTGGAAAGGT CTTTCTTGCT GAGTGCTACA ACCTTCTGAA TGATCAGGAC
AAGATGCTGG TGGCTGTCAA GGCACTGAAG GAGACATCTG AGAATGCTCG TCAGGACTTC
CATCGTGAGG CAGAGCTGCT CACCATGCTA CAGCACCAAC ACATCGTACG CTTCTTTGGA
GTCTGCACGG AGGGTGGCCC ATTGCTCATG GTCTTCGAGT ACATGCGCCA TGGGGACCTC
AACCGTTTCC TCCGGTCCCA CGGACCTGAT GCAAAACTGC TGGCTGGCGG CGAGGATGTG
GCTCCTGGTC CTTTGGGCCT TGGGCAGCTT CTGGCTGTGG CTAGCCAGGT GGCTGCTGGT
ATGGTGTACC TAGCCAGCCT GCACTTTGTG CACCGGGACC TGGCCACACG CAACTGTCTG
GTGGGTCAGG GACTAGTGGT CAAGATTGGA GACTTCGGCA TGAGCAGGGA CATCTACAGC
ACAGACTACT ACCGTGTGGG AGGTCGGACC ATGCTGCCCA TCCGCTGGAT GCCTCCAGAG
AGCATCCTCT ACCGCAAGTT CAGCACCGAG AGTGATGTGT GGAGCTTCGG GGTGGTGCTC
TGGGAGATCT TCACCTATGG AAAGCAACCC TGGTACCAGC TCTCCAACAC TGAGGCGATC
GAGTGCATCA CGCAGGGCCG GGAGCTGGAG CGGCCGCGCG CCTGCCCTCC TGATGTCTAC
GCCATCATGC GCGGCTGCTG GCAGCGTGAG CCGCAACAGC GCCTCAGCAT GAAGGATGTG
CACGCGCGGC TGCAGGCCTT GGCACAGGCG CCACCGAGTT ACCTGGACGT TCTGGGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_067600.1
CDS62..2461
Misc Feature(1)44..46
Misc Feature(2)263..337
Misc Feature(3)329..400
Misc Feature(4)335..511
Misc Feature(5)338..409
Misc Feature(6)407..472
Misc Feature(7)410..478
Misc Feature(8)479..517
Misc Feature(9)512..643
Misc Feature(10)647..913
Misc Feature(11)650..913
Misc Feature(12)908..913
Misc Feature(13)962..1207
Misc Feature(14)989..991
Misc Feature(15)order(1064..1066,1115..1120,1127..1129)
Misc Feature(16)1316..1387
Misc Feature(17)1475..1540
Misc Feature(18)1556..1558
Misc Feature(19)1556..1558
Misc Feature(20)1580..2419
Misc Feature(21)1598..2413
Misc Feature(22)order(1616..1627,1634..1636,1640..1642,1694..1696,1700..1702,1787..1789,1835..1846,2018..2020,2030..2035,2039..2041,2069..2074)
Misc Feature(23)2096..2098
Misc Feature(24)2108..2110
Misc Feature(25)2111..2113
Misc Feature(26)2441..2443
Misc Feature(27)2441..2443
Translation

Target ORF information:

RefSeq Version NM_021589.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus neurotrophic receptor tyrosine kinase 1 (Ntrk1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021589.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGCTGCGAG GCCAGCGGCA CGGGCAGCTG GGTTGGCATC GCCCGGCCGC GGGGCTAGGC 
GGTCTGGTGA CTTCGTTGAT GCTGGCTTGT GCTTGCGCCG CATCCTGTCG TGAGACCTGC
TGTCCCGTGG GCCCCTCGGG GTTGCGCTGC ACCAGGGCAG GGACCCTGAA TACCCTCCGC
GGCCTGCGGG GCGCCGGGAA CCTGACGGAG CTCTATGTGG AAAACCAGCG GGATCTGCAA
CGCCTGGAGT TTGAGGACCT GCAGGGCCTG GGGGAGTTGA GAAGCCTAAC CATCGTGAAG
AGTGGCCTCC GCTTTGTGGC CCCTGATGCC TTCCATTTCA CCCCTCGGCT CAGTCACCTG
AATCTCTCCT CCAATGCTTT GGAGTCCCTC TCCTGGAAAA CTGTGCAGGG CCTCTCCCTA
CAGGACTTGA CCCTGTCAGG GAACCCACTG CACTGTTCCT GTGCCCTATT GTGGCTCCAG
CGCTGGGAGC AGGAGGATTT GTGTGGTGTG TATACACAAA AGCTTCAGGG CTCTGGGTCT
GGAGACCAGT TCCTCCCACT GGGACACAAC AACAGTTGTG GTGTACCCTC AGTGAAGATC
CAGATGCCCA ATGACTCTGT GGAAGTGGGG GATGACGTTT TTCTGCAGTG CCAGGTGGAG
GGGCAGGCCC TACAGCAGGC TGACTGGATC CTCACAGAGC TGGAAGGGAC AGCCACCATG
AAGAAATCTG GAGATCTGCC ATCCCTGGGG CTAACTCTGG TCAATGTCAC CAGTGATCTC
AACAAGAAGA ATGTGACGTG CTGGGCAGAG AATGATGTGG GCCGGGCTGA GGTCTCTGTC
CAAGTCAGCG TCTCCTTCCC AGCCAGTGTG CATCTGGGCA AAGCCGTGGA ACAGCATCAC
TGGTGCATTC CCTTCTCTGT GGACGGGCAG CCAGCACCGT CCCTGCGCTG GTTCTTCAAC
GGCTCTGTGC TCAATGAGAC CAGCTTCATC TTCACTCAGT TCTTGGAGTC AGCGCTGACC
AATGAGACCA TGCGGCATGG CTGCCTTCGC CTCAACCAGC CCACGCATGT CAACAACGGG
AACTACACCC TGCTGGCTGC CAACCCCTAT GGCCAGGCTG CTGCCTCCAT CATGGCTGCC
TTTATGGACA ACCCTTTTGA GTTCAACCCT GAGGACCCCA TCCCTGTCTC CTTCTCGCCA
GTGGACACTA ACAGCACATC AAGAGACCCA GTGGAGAAGA AGGACGAAAC ACCTTTTGGG
GTCTCTGTGG CTGTGGGCCT GGCCGTCTCC GCCGCCCTCT TCCTTTCTGC CCTCCTCCTA
GTGCTCAACA AATGTGGACA GAGGAGCAAA TTTGGGATCA ACCGCCCTGC TGTGCTGGCG
CCAGAGGATG GGCTGGCCAT GTCCCTACAC TTCATGACAC TGGGTGGCAG TTCTCTTTCC
CCTACTGAGG GCAAAGGCTC CGGACTCCAG GGCCACATCA TGGAGAACCC ACAGTACTTC
AGTGATACCT GTGTCCACCA TATCAAGCGC CAGGACATCA TTCTCAAGTG GGAGCTAGGG
GAGGGAGCCT TTGGAAAGGT CTTTCTTGCT GAGTGCTACA ACCTTCTGAA TGATCAGGAC
AAGATGCTGG TGGCTGTCAA GGCACTGAAG GAGACATCTG AGAATGCTCG TCAGGACTTC
CATCGTGAGG CAGAGCTGCT CACCATGCTA CAGCACCAAC ACATCGTACG CTTCTTTGGA
GTCTGCACGG AGGGTGGCCC ATTGCTCATG GTCTTCGAGT ACATGCGCCA TGGGGACCTC
AACCGTTTCC TCCGGTCCCA CGGACCTGAT GCAAAACTGC TGGCTGGCGG CGAGGATGTG
GCTCCTGGTC CTTTGGGCCT TGGGCAGCTT CTGGCTGTGG CTAGCCAGGT GGCTGCTGGT
ATGGTGTACC TAGCCAGCCT GCACTTTGTG CACCGGGACC TGGCCACACG CAACTGTCTG
GTGGGTCAGG GACTAGTGGT CAAGATTGGA GACTTCGGCA TGAGCAGGGA CATCTACAGC
ACAGACTACT ACCGTGTGGG AGGTCGGACC ATGCTGCCCA TCCGCTGGAT GCCTCCAGAG
AGCATCCTCT ACCGCAAGTT CAGCACCGAG AGTGATGTGT GGAGCTTCGG GGTGGTGCTC
TGGGAGATCT TCACCTATGG AAAGCAACCC TGGTACCAGC TCTCCAACAC TGAGGCGATC
GAGTGCATCA CGCAGGGCCG GGAGCTGGAG CGGCCGCGCG CCTGCCCTCC TGATGTCTAC
GCCATCATGC GCGGCTGCTG GCAGCGTGAG CCGCAACAGC GCCTCAGCAT GAAGGATGTG
CACGCGCGGC TGCAGGCCTT GGCACAGGCG CCACCGAGTT ACCTGGACGT TCTGGGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

[Effects of ischemia on the expression of neurotrophins and their receptors in rat brain structures outside the lesion site, including on the opposite hemisphere].
Molekuliarnaia biologiia50(5)775-784(2016 Sep-Oct)
Dmitrieva VG,Stavchansky VV,Povarova OV,Skvortsova VI,Limborska SA,Dergunova LV


book

Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Journal of biomedical science22106(2015 Dec)
Gudasheva TA,Povarnina PY,Antipova TA,Firsova YN,Konstantinopolsky MA,Seredenin SB


book

The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells.
Experimental cell research333(1)49-59(2015 Apr)
Ceriani M,Amigoni L,D'Aloia A,Berruti G,Martegani E


book

RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.
PloS one10(11)e0142935(2015)
Tam SY,Lilla JN,Chen CC,Kalesnikoff J,Tsai M


book

Overexpression of NTRK1 Promotes Differentiation of Neural Stem Cells into Cholinergic Neurons.
BioMed research international2015857202(2015)
Wang L,He F,Zhong Z,Lv R,Xiao S,Liu Z


 
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