Fhit cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Fhit |
| Entrez Gene ID | 60398 |
| Full Name | fragile histidine triad |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | may play a role in the development of hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_021774.1 | NP_068542.1 | bis(5'-adenosyl)-triphosphatase |
| Pan troglodytes (chimpanzee) | FHIT | XP_001156390.2 |
| FHIT | XP_001094642.1 | |
| Canis lupus familiaris (dog) | FHIT | NP_001135729.1 |
| Danio rerio (zebrafish) | fhit | NP_957034.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_01517 | XP_003714490.1 |
| Rattus norvegicus (Norway rat) | Fhit | NP_068542.1 |
| Xenopus tropicalis (tropical clawed frog) | fhit | NP_001006883.1 |
| Danio rerio (zebrafish) | LOC100331277 | XP_002662597.1 |
| Eremothecium gossypii | AGOS_AAL053C | NP_982489.2 |
| Arabidopsis thaliana (thale cress) | FHIT | NP_200632.2 |
| Bos taurus (cattle) | FHIT | NP_001035736.1 |
| Mus musculus (house mouse) | Fhit | NP_034340.1 |
| Oryza sativa (rice) | Os11g0120600 | NP_001065609.2 |
| Homo sapiens (human) | FHIT | NP_001159715.1 |
| Gallus gallus (chicken) | FHIT | NP_001264731.1 |
| Saccharomyces cerevisiae (baker's yeast) | HNT2 | NP_010591.1 |
| Kluyveromyces lactis | KLLA0C10142g | XP_452651.1 |
| Schizosaccharomyces pombe (fission yeast) | aph1 | NP_587836.1 |
Related articles in PubMed
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
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Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
Weiske J, Albring KF, Huber O
Proceedings of the National Academy of Sciences of the United States of America104(51)20344-9(2007 Dec)
Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans.
Levin AM, Ray AM, Zuhlke KA, Douglas JA, Cooney KA
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology16(6)1294-7(2007 Jun)
Differential gene expression in nickel(II)-treated normal rat kidney cells.
Lee SH
Research communications in molecular pathology and pharmacology119(1-6)77-87(2006)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nickel(II) treatment down-regulated Fhit expression.
Title: Differential gene expression in nickel(II)-treated normal rat kidney cells.
There is an overall association of Fhit expression with regulatory region methylation, and hypermethylation patterns did not vary with carcinogen.
Title: Hypermethylation patterns in the Fhit regulatory region are tissue specific.
These results suggest that Fhit alterations may play important roles in hepatocarcinogenesis due to choline deficiency in rats.
Title: Fhit gene alterations in hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats.
examination of alterations in N-nitrosodiethylamine-induced hepatocellular carcinoma
Title: Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
Distribution of Fhit protein in rat tissues and its intracellular localization.
Title: Distribution of Fhit protein in rat tissues and its intracellular localization.
The following Fhit gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fhit cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa05226 | |
| Clone ID Related Accession (Same CDS sequence) | NM_021774.1 | |
| Accession Version | NM_021774.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | bis(5'-adenosyl)-triphosphatase | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF170064.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF170064.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## | |
1 | ATGTCATTTA AATTCGGCCA ACATCTCATC AAGCCCTCTG TGGTTTTCCT CAAAACCGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_068542.1 |
| CDS | 147..599 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_021774.1 |
ORF Insert Sequence:
1 | ATGTCATTTA AATTCGGCCA ACATCTCATC AAGCCCTCTG TGGTTTTCCT CAAAACCGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Pooled-matrix protein interaction screens using Barcode Fusion Genetics. |
|
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. |
|
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity. |
|
Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans. |
|
Differential gene expression in nickel(II)-treated normal rat kidney cells. |