Pygl cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Pygl |
| Entrez Gene ID | 64035 |
| Full Name | glycogen phosphorylase L |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | catalyzes the rate-limiting step of glycogen catabolism [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_022268.1 | NP_071604.1 | glycogen phosphorylase, liver form |
| Homo sapiens (human) | PYGL | NP_002854.3 |
| Gallus gallus (chicken) | PYGL | NP_989723.1 |
| Pan troglodytes (chimpanzee) | PYGL | XP_001145433.2 |
| Mus musculus (house mouse) | Pygl | NP_573461.2 |
| Saccharomyces cerevisiae (baker's yeast) | GPH1 | NP_015486.1 |
| Eremothecium gossypii | AGOS_AFR547W | NP_986094.1 |
| Arabidopsis thaliana (thale cress) | AT3G29320 | NP_189578.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_01819 | XP_003714833.1 |
| Neurospora crassa | NCU07027 | XP_962166.2 |
| PYGL | XP_001102253.1 | |
| Xenopus tropicalis (tropical clawed frog) | pygl | XP_002936619.1 |
| Canis lupus familiaris (dog) | PYGL | XP_003639242.1 |
| Bos taurus (cattle) | PYGL | NP_001068671.1 |
| Rattus norvegicus (Norway rat) | Pygl | NP_071604.1 |
| Kluyveromyces lactis | KLLA0F10065g | XP_455538.1 |
Related articles in PubMed
Proteomic investigation of signatures for geniposide-induced hepatotoxicity.
Wei J, Zhang F, Zhang Y, Cao C, Li X, Li D, Liu X, Yang H, Huang L
Journal of proteome research13(12)5724-33(2014 Dec)
Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, B?cavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1.
Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y, Zhao S, Guan KL
Cell metabolism15(1)75-87(2012 Jan)
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J
Science (New York, N.Y.)325(5938)332-6(2009 Jul)
Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Zibrova D, Grempler R, Streicher R, Kauschke SG
The Biochemical journal412(2)359-66(2008 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that two biomarkers, glycine N-methyltransferase (GNMT) and glycogen phosphorylase (PYGL), were found to indicate early hepatic injuries.
Title: Proteomic investigation of signatures for geniposide-induced hepatotoxicity.
Data show that inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Title: Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Liver-type glycogen phosphorylase can also catalyze reduction of arsenate.
Title: Glutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors.
glycogen phosphorylase has a role in 5-phosphoribosyl-1-pyrophosphate generation in liver tissue in the basal (postabsorptive) state
Title: Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures.
Results suggest that a signalling pathway involving dephosphorylation of phosphorylase a, leading to both activation and translocation of glycogen synthase, is a critical component of the mechanism by which insulin stimulates hepatic glycogen synthesis.
Title: Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.
The following Pygl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pygl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa05587 | |
| Clone ID Related Accession (Same CDS sequence) | NM_022268.1 | |
| Accession Version | NM_022268.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2553bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | glycogen phosphorylase, liver form | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X63515.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X63515.1, BC070901.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGGCGAAGC CCTTGACCGA CCAGGAAAAG CGACGGCAGA TCAGCATCCG CGGCATCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_071604.1 |
| CDS | 16..2568 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_022268.1 |
ORF Insert Sequence:
1 | ATGGCGAAGC CCTTGACCGA CCAGGAAAAG CGACGGCAGA TCAGCATCCG CGGCATCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Proteomic investigation of signatures for geniposide-induced hepatotoxicity. |
|
Impact of lactobacilli on orally acquired listeriosis. |
|
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. |
|
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. |
|
Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes. |