Gene Symbol | Kcnc4 |
Entrez Gene ID | 684516 |
Full Name | potassium voltage-gated channel subfamily C member 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Kcnc4 cDNA ORF clone
Gene Symbol | Kcnc4 |
Entrez Gene ID | 684516 |
Full Name | potassium voltage-gated channel subfamily C member 4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001122776.1 | NP_001116248.1 | potassium voltage-gated channel subfamily C member 4 |
Homo sapiens (human) | KCNC4 | NP_001034663.1 |
Pan troglodytes (chimpanzee) | KCNC4 | XP_513651.2 |
Canis lupus familiaris (dog) | KCNC4 | XP_547235.3 |
Rattus norvegicus (Norway rat) | Kcnc4 | NP_001116248.1 |
Danio rerio (zebrafish) | kcnc4 | NP_001182125.1 |
Bos taurus (cattle) | KCNC4 | NP_001179709.1 |
Mus musculus (house mouse) | Kcnc4 | NP_666034.1 |
Gallus gallus (chicken) | KCNC4 | XP_003642768.1 |
KCNC4 | XP_001099694.1 | |
Xenopus tropicalis (tropical clawed frog) | kcnc4 | XP_002933043.1 |
Kv3.4 channel function and dysfunction in nociceptors.
Ritter DM, Zemel BM, Lepore AC, Covarrubias M
Channels (Austin, Tex.)9(4)209-17(2015)
Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.
Huang CY, Chu D, Hwang WC, Tsaur ML
The Journal of comparative neurology520(16)3650-72(2012 Nov)
Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.
Boda E, Hoxha E, Pini A, Montarolo F, Tempia F
Journal of molecular neuroscience : MN46(3)606-15(2012 Mar)
KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel ?-subunit composition.
Kanda VA, Lewis A, Xu X, Abbott GW
Biophysical journal101(6)1364-75(2011 Sep)
KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels.
Kanda VA, Lewis A, Xu X, Abbott GW
Biophysical journal101(6)1354-63(2011 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data indicate ubiquitous expression of Kv3.4 potassium channel protein in nociceptors.
Title: Kv3.4 channel function and dysfunction in nociceptors.
the 15-lipoxygenase pathway via its metabolite, 15-hydroxyeicosatetraenoic acid , seems to play a role in the down-regulation of Kv3.4
Title: Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells.
Given the role of the Kv3 proteins in shaping neuronal excitability, these data highlight a role for homomeric Kv3.4 channels in spike timing and neurotransmitter release in low frequency firing neurons of the DVN.
Title: Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin.
Kv3.4 is expressed in nociceptive dorsal root ganglion neurons and is greatly reduced following neuropathic pain.
Title: Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity.
Up-regulation and increased activity of KV3.4 channels and their accessory sububnit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.
Title: Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death.
The following Kcnc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa01229 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122776.1 | |
Accession Version | NM_001122776.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | potassium voltage-gated channel subfamily C member 4 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X62841.1. On Jan 24, 2009 this sequence version replaced XM_001070801.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: X62841.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATCAGCT CGGTGTGTGT CTCCTCCTAC CGCGGGCGCA AGTCGGGGAA CAAGCCTCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001116248.1 |
CDS | 400..2277 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001122776.1 |
1 | ATGATCAGCT CGGTGTGTGT CTCCTCCTAC CGCGGGCGCA AGTCGGGGAA CAAGCCTCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Kv3.4 channel function and dysfunction in nociceptors. |
Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. |
Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. |
KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel ?-subunit composition. |
KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. |